Centre for Neuroscience - Theses
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ItemFeedback regulation of olfactory neurogenesis in the adult brain( 2011)The findings described in this thesis provide evidence to support that 1) selective inhibition targeting cyclooxygenase-2 (COX-2) may protect dopaminergic neurons in the substantia nigra par compacta from death by attenuating microglial activation; 2) the olfactory system is a system that regulates niche cell types. In the second part of this thesis, to determine the influence of impaired subventricular proliferation on the neurogenesis in olfactory system, I used two different mouse models: the acute 6-OHDA intranigral model and the long-term cholecystokinin A receptor gene ablated (CCK AR -/-) mouse model. A number of cell types were labeled by immunoreactive markers and were quantified with stereological counting method. The number of mature olfactory neurons was not affected in 6-OHDA model because of the compensatory increased survival of neuroblasts and newborn interneurons; whereas this steadiness can not be remained long-term as periglomerular neurons were decreased in CCK AR -/- mice. Another major finding is, in the acute model, newborn dopaminergic and γ-Aminobutyric acid-ergic interneurons in the olfactory bulb were even increased despite the proliferative reduction. It was concluded that in the adult brain, survival of cells produced by neurogenesis is regulated and related to the rate at which new cells are born. Collectively, the underlying mechanism involved in this study may be manipulated to maintain or enhance the survival of grafted cells in cell replacement therapies.