Anatomy and Neuroscience - Research Publications

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Author: Pera, Martin × End date: 1999 × Start date: 1980 ×

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    EXCEPTIONAL SENSITIVITY OF TESTICULAR GERM-CELL TUMOR-CELL LINES TO THE NEW ANTICANCER AGENT, TEMOZOLOMIDE
    PERA, MF ; KOBERLE, B ; MASTERS, JRW (NATURE PUBLISHING GROUP, 1995-05)
    Metastatic testicular germ cell tumours are cured in approximately 85% of patients using cisplatin-based combination chemotherapy. Patients who fail to respond have a poor prognosis, and there is a need for more effective treatments for cisplatin-resistant disease. In this study, it is shown that two of four cell lines derived from human non-seminomatous testicular germ cell tumours are exceptionally sensitive to temozolomide, a new imidazotetrazine which can cross the blood-brain barrier in mice. In addition, three pairs of cisplatin-resistant sublines show little cross-resistance to temozolomide. These data suggest that temozolomide might have activity against non-seminomatous testicular germ cell tumours which have relapsed following cisplatin-containing chemotherapy, and could have a role in the treatment of patients with metastatic lesions in the brain.
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    A PANEL OF HUMAN-LUNG CARCINOMA LINES - ESTABLISHMENT, PROPERTIES AND COMMON CHARACTERISTICS
    DUCHESNE, GM ; EADY, JJ ; PEACOCK, JH ; PERA, MF (SPRINGERNATURE, 1987-09)
    A panel of human lung carcinoma lines representing the four main histological types (squamous, small-cell, large-cell and adenocarcinoma), and derived from both primary and metastatic sites, has been established in xenograft and in tissue culture. The highest take rates were achieved when biopsy specimens were obtained from large tumour masses and cultured lines were most readily established after preliminary passages as xenografts. The established lines exhibited an overlapping spectrum of biochemical and morphological characteristics, and showed a tendency to change from one cell type to another, in keeping with the concept of a common endodermal cell of origin. Radiation resistance appeared to be related to the large-cell phenotype.