Medicine (RMH) - Theses

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Author: Chang, Melody Wei-Ning × End date: 2019 × Start date: 2010 × Subject: inflammation ×

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    Regulation of a cytokine pathway in inflammation and arthritis
    Chang, Melody Wei-Ning ( 2015)
    Rheumatoid arthritis (RA) is an idiopathic autoimmune/inflammatory joint disease. The involvement of granulocyte macrophage colony-stimulating factor (GM-CSF) in the pathogenesis of RA is being indicated in clinical trials, but the underlying mechanism of action is still unclear. GM-CSF exhibits macrophage (MΦ)-polarising properties, where it can generate a more pro-inflammatory MΦ population. This thesis illustrates, for the first time, an important signalling cascade involving GM-CSF that is important for the development of murine inflammatory arthritis models.