Otolaryngology - Research Publications

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Author: Caruso, Francesco × Author: Shepherd, Robert × Author: Tan, Justin ×

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    Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration
    Tan, J ; Wang, Y ; Yip, X ; Glynn, F ; Shepherd, RK ; Caruso, F (WILEY-V C H VERLAG GMBH, 2012-07-03)
    Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.
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    Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery
    Wang, Y ; Maina, JW ; Caruso, F ; Wise, AK ; Shepherd, RK ; Tan, J (Wiley, 2014)
    Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force action in confined droplets. The MS-SPs are effective carriers for sustained drug delivery. Animal studies show that these particles are suitable for chronic intracochlear implantation, and neurotrophins released from the MS-SPs can efficiently rescue primary auditory neurons in an in vivo sensorineural hearing loss model.
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    Drug delivery: mesoporous silica supraparticles for sustained inner-ear drug delivery (small 21/2014).
    Wang, Y ; Wise, AK ; Tan, J ; Maina, JW ; Shepherd, RK ; Caruso, F (Wiley, 2014-11)
    Mesoporous silica supraparticles (MS-SPs) self-assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caruso and co-workers. The MS-SPs are effective carriers for the sustained delivery of brain-derived neurotrophic factor. Animal studies show that the MS-SPs can be implanted into the cochlea and deliver neurotrophins to prevent the progressive loss of the auditory neurons that normally occurs with deafness.