Anatomy and Neuroscience - Theses

Permanent URI for this collection

http://hdl.handle.net/11343/182

Filters

2014 1
1
Reset filters

Settings
Statistics
Citations
Subject: neuroscience × Subject: myelin × Author: Ferner, Anita Hilja ×

Search Results

Now showing 1 - 1 of 1
  • Item
    Thumbnail Image
    Investigation of the mechanisms BDNF utilises to promote central nervous system myelination
    Ferner, Anita Hilja ( 2014)
    Brain-derived neurotrophic factor (BDNF) promotes CNS myelination, which is crucial for normal CNS function. This thesis investigates the influence BDNF and its signalling exerts upon myelination. Surprisingly, I found that conditional deletion of TrkB in oligodendroglia exerted no effect on myelination in vivo. However, over-expression of Erk2, a molecule activated by BDNF signalling, promotes myelination in vitro. I found that Erk1/2 interacts with and phosphorylates the oligodendroglial transcription factors Olig1 and Olig2, which may contribute to Erk1/2’s promyelinating effects.