Centre for Youth Mental Health - Research Publications

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    Personality disorder among youth with first episode psychotic mania: An important target for specific treatment?
    Hasty, MK ; Macneil, CA ; Cotton, SM ; Berk, M ; Kader, L ; Ratheesh, A ; Ramain, J ; Chanen, AM ; Conus, P (WILEY, 2021-03-25)
    AIM: Personality disorder is a common co-occurrence ('comorbidity') among patients with bipolar disorder and appears to affect outcome negatively. However, there is little knowledge about the impact of this comorbidity in the early phases of bipolar disorder. We examined the prevalence and effect of personality disorder co-occurrence on outcome in a cohort of youth with first episode mania with psychotic features. METHODS: Seventy-one first episode mania patients, aged 15-29, were assessed at baseline, 6, 12, and 18 months as part of a randomized controlled trial of olanzapine and chlorpromazine as add-on to lithium in first episode mania with psychotic features. The current study involved secondary analysis of trial data. RESULTS: A co-occurring clinical personality disorder diagnosis was present in 16.9% of patients. Antisocial and narcissistic personality disorders were the most common diagnoses. Patients with co-occurring personality disorder had higher rates of readmission to hospital, lower rates of symptomatic recovery and poorer functional levels at 6 months, but these differences disappeared after 12 and 18 months. CONCLUSIONS: In the early phase of bipolar disorder, patients with personality disorder comorbidity display delayed symptomatic and functional recovery and increased likelihood to need hospital readmissions. These observations suggest that routine assessment for personality disorder and specific interventions are important in order to improve short-term treatment efficacy in this subgroup.
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    Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD working group
    Leerssen, J ; Blanken, TF ; Pozzi, E ; Jahanshad, N ; Aftanas, L ; Andreassen, OA ; Baune, BT ; Ching, CRK ; Dannlowski, U ; Frodl, T ; Godlewska, BR ; Gotlib, IH ; Grotegerd, D ; Gruber, O ; Hatton, SN ; Hickie, IB ; Jaworska, N ; Kircher, T ; Krug, A ; Lagopoulos, J ; Li, M ; MacMaster, FP ; McIntosh, AM ; Mwangi, B ; Osipov, E ; Portella, MJ ; Sacchet, MD ; Samann, PG ; Simulionyte, E ; Soares, JC ; Walter, M ; Whalley, HC ; Veltman, DJ ; Thompson, PM ; Schmaal, L ; Van Someren, EJW (WILEY, 2020-09-01)
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    S94. PREDICTION OF CANNABIS RELAPSE IN CLINICAL HIGH-RISK INDIVIDUALS AND RECENT ONSET PSYCHOSIS - PRELIMINARY RESULTS FROM THE PRONIA STUDY
    Penzel, N ; Sanfelici, R ; Betz, L ; Antonucci, L ; Falkai, P ; Upthegrove, R ; Bertolino, A ; Borgwardt, S ; Brambilla, P ; Lencer, R ; Meisenzahl, E ; Ruhrmann, S ; Salokangas, RKR ; Pantelis, C ; Schultze-Lutter, F ; Wood, S ; Koutsouleris, N ; Kambeitz, J (Oxford University Press (OUP), 2020-05-18)
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    T223. MULTIVARIATE PREDICTION OF FOLLOW UP SOCIAL AND OCCUPATIONAL OUTCOME IN CLINICAL HIGH-RISK INDIVIDUALS BASED ON GRAY MATTER VOLUMES AND HISTORY OF ENVIRONMENTAL ADVERSE EVENTS
    Antonucci, L ; Pigoni, A ; Sanfelici, R ; Kambeitz-Ilankovic, L ; Dwyer, D ; Ruef, A ; Chisholm, K ; Haidl, T ; Rosen, M ; Kambeitz, J ; Ruhrmann, S ; Schultze-Lutter, F ; Falkai, P ; Lencer, R ; Dannlowski, U ; Upthegrove, R ; Salokangas, R ; Pantelis, C ; Meisenzahl, E ; Wood, S ; Brambilla, P ; Borgwardt, S ; Bertolino, A ; Koutsouleris, N (Oxford University Press (OUP), 2020-05-18)
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    T21. DEVELOPMENT OF PROTEOMIC PREDICTION MODELS FOR OUTCOMES IN THE CLINICAL HIGH RISK STATE AND PSYCHOTIC EXPERIENCES IN ADOLESCENCE: MACHINE LEARNING ANALYSES IN TWO NESTED CASE-CONTROL STUDIES
    Mongan, D ; Föcking, M ; Healy, C ; Raj Susai, S ; Cagney, G ; Cannon, M ; Zammit, S ; Nelson, B ; McGorry, P ; Nordentoft, M ; Krebs, M-O ; Riecher-Rössler, A ; Bressan, R ; Barrantes-Vidal, N ; Borgwardt, S ; Ruhrmann, S ; Sachs, G ; Van der Gaag, M ; Rutten, B ; Pantelis, C ; De Haan, L ; Valmaggia, L ; Kempton, M ; McGuire, P ; Cotter, D (Oxford University Press (OUP), 2020-05-18)
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    O6.6. MULTIMODAL PROGNOSIS OF NEGATIVE SYMPTOM SEVERITY IN INDIVIDUALS WITH INCREASED RISK OF DEVELOPING PSYCHOSIS
    Hauke, D ; Schmidt, A ; Studerus, E ; Andreou, C ; Riecher-Rössler, A ; Radua, J ; Kambeitz, J ; Ruef, A ; Dwyer, D ; Sanfelici, R ; Penzel, N ; Haas, S ; Antonucci, L ; Schultze-Lutter, F ; Ruhrmann, S ; Hietala, J ; Brambilla, P ; Koutsouleris, N ; Meisenzahl, E ; Pantelis, C ; Rosen, M ; Salokangas, RKR ; Upthegrove, R ; Wood, S ; Borgwardt, S (Oxford University Press (OUP), 2020-05-18)