Melbourne Institute of Applied Economic and Social Research - Research Publications

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Start date: 2015 × End date: 2017 × Author: Butterworth, Peter × Author: MacKinnon, Andrew ×

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    The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration
    Sachdev, PS ; Lipnicki, DM ; Kochan, NA ; Crawford, JD ; Thalamuthu, A ; Andrews, G ; Brayne, C ; Matthews, FE ; Stephan, BCM ; Lipton, RB ; Katz, MJ ; Ritchie, K ; Carriere, I ; Ancelin, M-L ; Lam, LCW ; Wong, CHY ; Fung, AWT ; Guaita, A ; Vaccaro, R ; Davin, A ; Ganguli, M ; Dodge, H ; Hughes, T ; Anstey, KJ ; Cherbuin, N ; Butterworth, P ; Ng, TP ; Gao, Q ; Reppermund, S ; Brodaty, H ; Schupf, N ; Manly, J ; Stern, Y ; Lobo, A ; Lopez-Anton, R ; Santabarbara, J ; Arendt, T (PUBLIC LIBRARY SCIENCE, 2015-11-05)
    BACKGROUND: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). METHODS: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. RESULTS: The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01). CONCLUSION: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.