Medical Bionics - Research Publications

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Start date: 2003 × Author: Wise, Andrew × Author: Caruso, Francesco × Author: Shepherd, Robert × Author: MAINA, JAMES ×

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    Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery
    Wang, Y ; Maina, JW ; Caruso, F ; Wise, AK ; Shepherd, RK ; Tan, J (Wiley, 2014)
    Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force action in confined droplets. The MS-SPs are effective carriers for sustained drug delivery. Animal studies show that these particles are suitable for chronic intracochlear implantation, and neurotrophins released from the MS-SPs can efficiently rescue primary auditory neurons in an in vivo sensorineural hearing loss model.
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    Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs
    Maina, JW ; Cui, J ; Bjoernmalm, M ; Wise, AK ; Shepherd, RK ; Caruso, F (AMER CHEMICAL SOC, 2014-11)
    This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demonstrates their potential as vehicles for codelivery of brain-derived neurotrophic factor (BDNF) and dexamethasone (DEX). The MS supraparticles are assembled using gelatin as a biodegradable adhesive to bind and cross-link the particles. Microfabricated molds made of polydimethylsiloxane are used to control the size and shape of the supraparticles. The obtained mesoporous silica-gelatin hybrid supraparticles (MSG-SPs) are stable in water as well as in organic solvents, such as dimethyl sulfoxide, and efficiently coencapsulate both BDNF and DEX. The MSG-SPs also exhibit sustained release kinetics in simulated physiological conditions (>30 days), making them potential candidates for long-term delivery of therapeutics to the inner ear.
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    Drug delivery: mesoporous silica supraparticles for sustained inner-ear drug delivery (small 21/2014).
    Wang, Y ; Wise, AK ; Tan, J ; Maina, JW ; Shepherd, RK ; Caruso, F (Wiley, 2014-11)
    Mesoporous silica supraparticles (MS-SPs) self-assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caruso and co-workers. The MS-SPs are effective carriers for the sustained delivery of brain-derived neurotrophic factor. Animal studies show that the MS-SPs can be implanted into the cochlea and deliver neurotrophins to prevent the progressive loss of the auditory neurons that normally occurs with deafness.