Florey Department of Neuroscience and Mental Health - Theses

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Author: Pracejus, Natasha Heide × Start date: 2015 × Subject: neuroscience ×

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    Functional tracing of brain pathways with optogenetics: insights into the hierarchy of sympathetic control
    Pracejus, Natasha Heide ( 2017)
    Brainstem premotor neurons can selectively drive sympathetic neurons of one functional type, but methodological constraints have prevented previous studies from identifying premotor neurons that drive more than one functional type. This project tested whether individual premotor neurons might drive two or more functional outputs using optogenetics, which genetically renders selected neurons light-sensitive. This study found that there are indeed premotor neurons with branched projections capable of exciting more than one functional type of sympathetic neuron.