School of Mathematics and Statistics - Research Publications

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    Dynamics of undeforming regions in the lead up to failure: jumping scales from lab to field
    Tordesillas, A ; Zhou, S ; Campbell, L ; Bellett, P ; Aguirre, MA ; Luding, S ; Pugnaloni, LA ; Soto, R (EDP Sciences, 2021-06-07)
    Knowledge transfer from micromechanics of granular media failure to geohazard forecasting and mitigation has been slow. But in the face of a rapidly expanding data infrastructure on the motion of individual grains for laboratory samples – and ground motion data at the field scale – opportunities to accelerate this knowledge transfer are emerging. In particular, such data assets coupled with data-driven approaches enable ‘new eyes’ to re-examine granular failure. To this end, effective strategies that can jump scales from bench to field are urgently needed. Here we demonstrate one strategy that focusses on the study of deformation patterns in the precursory failure regime using kinematic data. Unlike previous studies which focus on regions of high strains, here we probe the development and evolution of near-undeforming regions through the lens of explosive percolation. We find a common dynamical signature in which undeforming regions, which are initially transient in the precursory failure regime, become persistent from the time of imminent failure. We demonstrate the robustness of these findings for data on individual grain motions in a classical laboratory test and ground motion in two real landslides at vastly different scales.
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    A TOOLKIT FOR THE QUANTITATIVE ANALYSIS OF THE SPATIAL DISTRIBUTION OF CELLS OF THE TUMOR IMMUNE MICROENVIRONMENT
    Trigos, A ; Yang, T ; Feng, Y ; Ozcoban, V ; Doyle, M ; Pasam, A ; Kocovski, N ; Pizzolla, A ; Huang, Y-K ; Bass, G ; Keam, S ; Speed, T ; Neeson, P ; Sandhu, S ; Goode, D (BMJ PUBLISHING GROUP, 2020-11)
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    The linear ubiquitin chain assembly complex: a new function in thymic T cell differentiation and regulatory T cell homeostasis
    Teh, C ; Lalaoui, N ; Jain, R ; Policheni, A ; Heinlein, M ; Alvarez-Diaz, S ; Rieser, E ; Deuser, S ; Koay, H-F ; Hu, Y ; Kupresanin, F ; O'Reilly, L ; Godfrey, D ; Smyth, G ; Bouillet, P ; Strasser, A ; Walczak, H ; Silke, J ; Gray, D (WILEY-BLACKWELL, 2016-08)
    The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3+ regulatory T (Treg)-cell development and Treg cell homeostasis. LUBAC activity is not required to prevent TNF-induced apoptosis or necroptosis but is necessary for the transcriptional programme of the penultimate stage of thymocyte differentiation. Treg cell-specific ablation of HOIP causes severe Treg cell deficiency and lethal immune pathology, revealing an ongoing requirement of LUBAC activity for Treg cell homeostasis. These data reveal stage-specific requirements for LUBAC in coordinating the signals required for T-cell differentiation.