- Biochemistry and Pharmacology - Research Publications
Biochemistry and Pharmacology - Research Publications
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ItemNo Preview AvailableExploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource (vol 52, pg 999, 2020)Portelli, S ; Olshansky, M ; Rodrigues, CHM ; D'Souza, EN ; Myung, Y ; Silk, M ; Alavi, A ; Pires, DEV ; Ascher, DB (NATURE RESEARCH, 2021-02)
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ItemmCSM-PPI2: predicting the effects of mutations on protein-protein interactionsRodrigues, CHM ; Myung, Y ; Pires, DEV ; Ascher, DB (OXFORD UNIV PRESS, 2019-07-02)Protein-protein Interactions are involved in most fundamental biological processes, with disease causing mutations enriched at their interfaces. Here we present mCSM-PPI2, a novel machine learning computational tool designed to more accurately predict the effects of missense mutations on protein-protein interaction binding affinity. mCSM-PPI2 uses graph-based structural signatures to model effects of variations on the inter-residue interaction network, evolutionary information, complex network metrics and energetic terms to generate an optimised predictor. We demonstrate that our method outperforms previous methods, ranking first among 26 others on CAPRI blind tests. mCSM-PPI2 is freely available as a user friendly webserver at http://biosig.unimelb.edu.au/mcsm_ppi2/.