Biochemistry and Pharmacology - Research Publications

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Author: Cui, Jiwei × Author: JOHNSTON, ANGUS × Author: LIANG, KANG ×

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    Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles
    Cui, J ; De Rose, R ; Best, JP ; Johnston, APR ; Alcantara, S ; Liang, K ; Such, GK ; Kent, SJ ; Caruso, F (WILEY-V C H VERLAG GMBH, 2013-07-05)
    DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.
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    Endocytic pH-Triggered Degradation of Nanoengineered Multilayer Capsules
    Liang, K ; Such, GK ; Johnston, APR ; Zhu, Z ; Ejima, H ; Richardson, JJ ; Cui, J ; Caruso, F (WILEY-V C H VERLAG GMBH, 2014-03)
    The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake.