Biochemistry and Pharmacology - Research Publications

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Author: Parker, Michael × Author: Gorman, Michael × Author: Ackermann, Uwe ×

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    Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography
    Dickmann, CGF ; McDonald, AFF ; Huynh, N ; Rigopoulos, A ; Liu, Z ; Guo, N ; Osellame, LDD ; Gorman, MAA ; Parker, MWW ; Gan, HKK ; Scott, AMM ; Ackermann, U ; Burvenich, IJG ; White, JMM (ROYAL SOC CHEMISTRY, 2023-03-09)
    Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been targeted for molecular imaging of cancer. Here, we report the development of a novel molecule radiolabelled with positron emitting fluorine-18, [18F]BiPET-2, and its in vitro and preclinical evaluation in glioblastoma models.