Biochemistry and Pharmacology - Research Publications

Permanent URI for this collection

Search Results

Now showing 1 - 3 of 3
  • Item
    No Preview Available
    Feasibility of a Chronic, Minimally Invasive Endovascular Neural Interface
    Opie, NL ; Rind, GS ; John, SE ; Ronayne, SM ; Grayden, DB ; Burkitt, AN ; May, CN ; O'Brien, TJ ; Oxley, TJ ; Patton, J ; Barbieri, R ; Ji, J ; Jabbari, E ; Dokos, S ; Mukkamala, R ; Guiraud, D ; Jovanov, E ; Dhaher, Y ; Panescu, D ; Vangils, M ; Wheeler, B ; Dhawan, AP (IEEE, 2016)
    Development of a neural interface that can be implanted without risky, open brain surgery will increase the safety and viability of chronic neural recording arrays. We have developed a minimally invasive surgical procedure and an endovascular electrode-array that can be delivered to overlie the cortex through blood vessels. Here, we describe feasibility of the endovascular interface through electrode viability, recording potential and safety. Electrochemical impedance spectroscopy demonstrated that electrode impedance was stable over 91 days and low frequency phase could be used to infer electrode incorporation into the vessel wall. Baseline neural recording were used to identify the maximum bandwidth of the neural interface, which remained stable around 193 Hz for six months. Cross-sectional areas of the implanted vessels were non-destructively measured using the Australian Synchrotron. There was no case of occlusion observed in any of the implanted animals. This work demonstrates the feasibility of an endovascular neural interface to safely and efficaciously record neural information over a chronic time course.
  • Item
    Thumbnail Image
    Exploring misconceptions as a trigger for enhancing student learning
    Verkade, H ; Lodge, JM ; Elliott, K ; Mulhern, TD ; Espinosa, AA ; Cropper, SJ ; Rubinstein, BIP ; Walker, R ; Bedford, S (Higher Education Research and Development Society of Australasia, Inc, 2017)
    This article addresses the importance of confronting misconceptions in the teaching of the STEM disciplines. First, we review the central place for threshold concepts in many disciplines and the threat misconceptions pose to quality education. Second, approaches will be offered for confronting misconceptions in the classroom in different contexts. Finally, we discuss what we can learn about these approaches and the common threads that reveal successful approaches. These steps have been explored in relation to four case studies across diverse disciplines. From these case studies, a set of principles about how best to address misconceptions in STEM disciplines has been distilled. As conceptual knowledge increases in importance in higher education, effective strategies for helping students develop accurate conceptual understanding will also be increasingly critical.
  • Item
    Thumbnail Image
    Precision Medicine: Dawn of Supercomputing in ‘omics Research
    Reumann, M ; Holt, KE ; Inouye, M ; Stinear, T ; Goudey, B ; Abraham, G ; WANG, Q ; Shi, F ; Kowalczyk, A ; Pearce, A ; Isaac, A ; Pope, BJ ; Butzkueven, H ; Wagner, J ; Moore, S ; Downton, M ; Church, PC ; Turner, SJ ; Field, J ; Southey, M ; Bowtell, D ; Schmidt, D ; Makalic, E ; Zobel, J ; Hopper, J ; Petrovski, S ; O'Brien, T (eResearch Australasia, 2011)