Biochemistry and Pharmacology - Research Publications

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Type: Journal Article × Start date: 2020 × End date: 2022 × Author: McConville, Malcolm × Author: Saunders, Eleanor × Author: La Gruta, Nicole ×

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    Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality (vol 11, 2857, 2020)
    Quinn, KM ; Hussain, T ; Kraus, F ; Formosa, LE ; Lam, WK ; Dagley, MJ ; Saunders, EC ; Assmus, LM ; Wynne-Jones, E ; Loh, L ; van de Sandt, CE ; Cooper, L ; Good-Jacobson, KL ; Kedzierska, K ; Mackay, LK ; McConville, MJ ; Ramm, G ; Ryan, MT ; La Gruta, NL (NATURE PUBLISHING GROUP, 2020-07-09)
    An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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    Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
    Quinn, KM ; Hussain, T ; Kraus, F ; Formosa, LE ; Lam, WK ; Dagley, MJ ; Saunders, EC ; Assmus, LM ; Wynne-Jones, E ; Loh, L ; van de Sandt, CE ; Cooper, L ; Good-Jacobson, KL ; Kedzierska, K ; Mackay, LK ; McConville, MJ ; Ramm, G ; Ryan, MT ; La Gruta, NL (NATURE PUBLISHING GROUP, 2020-06-05)
    Virtual memory T (TVM) cells are antigen-naïve CD8+ T cells that exist in a semi-differentiated state and exhibit marked proliferative dysfunction in advanced age. High spare respiratory capacity (SRC) has been proposed as a defining metabolic characteristic of antigen-experienced memory T (TMEM) cells, facilitating rapid functionality and survival. Given the semi-differentiated state of TVM cells and their altered functionality with age, here we investigate TVM cell metabolism and its association with longevity and functionality. Elevated SRC is a feature of TVM, but not TMEM, cells and it increases with age in both subsets. The elevated SRC observed in aged mouse TVM cells and human CD8+ T cells from older individuals is associated with a heightened sensitivity to IL-15. We conclude that elevated SRC is a feature of TVM, but not TMEM, cells, is driven by physiological levels of IL-15, and is not indicative of enhanced functionality in CD8+ T cells.