School of BioSciences - Research Publications

Permanent URI for this collection

http://hdl.handle.net/11343/57446

Filters

2015 1
1
Reset filters

Settings
Statistics
Citations
Author: Boughton, Berin × Author: Dias, Daniel × Author: Roessner, Ute × End date: 2019 × Start date: 2015 ×

Search Results

Now showing 1 - 1 of 1
  • Item
    Thumbnail Image
    Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model
    Van Assche, R ; Temmerman, L ; Dias, DA ; Boughton, B ; Boonen, K ; Braeckman, BP ; Schoofs, L ; Roessner, U (SPRINGER, 2015-04)
    Despite decades of research, no early-onset biomarkers are currently available for Alzheimer's disease, a cureless neurodegenerative disease afflicting millions worldwide. In this study, transgenic Caenorhabditis elegans were used to investigate changes in the metabolome after induced expression of amyloid-β. GC- and LC-MS-based platforms determined a total of 157 differential features. Some of these were identified using in-house (GC-MS) or public libraries (LC-MS), revealing changes in allantoin, cystathionine and tyrosine levels. Since C. elegans is far better suited to metabolomics studies than most other model systems, the accordance of these findings with vertebrate literature is promising and argues for further use of C. elegans as a model of human pathology in the study of AD.