Medicine (St Vincent's) - Theses

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Author: Judkins, Christopher × End date: 2017 × Start date: 2017 × Type: PhD thesis ×

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    Protein and lipid markers of coronary artery disease
    Judkins, Christopher ( 2017)
    Identification of high risk coronary lesions, plaque rupture, early myocardial ischemia and in-stent restenosis (ISR) remains a clinical challenge. We employed proteomic, lipidomic and traditional approaches to identify novel biomarkers. TMEM198 was identified as a marker of plaque rupture. 42 proteins and multiple lipids identified early myocardial ischemia. 12 proteins and 2 lipids identified ISR. Phospholipase A2 was associated with periprocedural ischemia. Combined, these experiments utilise unbiased methodologies for novel cardiac biomarker discovery.