Psychiatry - Research Publications

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Author: Rossell, Susan × Author: TAN, ERIC × Author: van Rheenen, Tamsyn × End date: 2019 × Start date: 2015 ×

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    Do schizotypy dimensions reflect the symptoms of schizophrenia?
    Thomas, EHX ; Rossell, SL ; Tan, EJ ; Neill, E ; Van Rheenen, TE ; Carruthers, SP ; Sumner, PJ ; Louise, S ; Bozaoglu, K ; Gurvich, C (SAGE PUBLICATIONS LTD, 2019-03)
    OBJECTIVE: The personality characteristics and symptoms observed in schizophrenia are postulated to lie on a continuum, with non-clinical manifestations referred to as schizotypy. High schizotypy behaviours are argued to correspond with the three main clusters of symptoms in schizophrenia: positive, negative and cognitive/disorganised symptoms, yet there is limited empirical evidence to support this. This study aimed to investigate whether schizotypy dimensions significantly correlate with their respective schizophrenia symptomatology in the largest sample to date. METHODS: A total of 361 adults (103 patients with schizophrenia/schizoaffective disorder and 258 healthy controls) were assessed for schizotypy using the Oxford-Liverpool Inventory of Feelings and Experiences. The MATRICS Consensus Cognitive Battery supplemented by the Stroop task and Wisconsin Card Sorting Test was administered to all participants to obtain objective measurements of cognition. Schizophrenia symptomatology was assessed using the Positive and Negative Syndrome Scale in patients only. RESULTS: The results demonstrated significant correlations between the Oxford-Liverpool Inventory of Feelings and Experiences positive and negative subscales and their respective Positive and Negative Syndrome Scale subscales only, indicating that positive and negative schizotypy dimensions across patients and controls accurately reflect the respective schizophrenia symptomatology observed in patients. Cognitive performance did not correlate with cognitive/disorganised symptom dimensions of the Oxford-Liverpool Inventory of Feelings and Experiences or the Positive and Negative Syndrome Scale, indicating that cognitive impairment is an independent symptom dimension that requires objective cognitive testing. CONCLUSION: Collectively, the findings provide empirical evidence for the continuum theory and support the use of schizotypy as a model for investigating schizophrenia.
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    The dopamine D1 receptor gene is associated with negative schizotypy in a non-clinical sample
    Gurvich, C ; Tan, EJ ; Bozaoglu, K ; Neill, E ; Louise, S ; Van Rheenen, TE ; Rossell, SL (ELSEVIER IRELAND LTD, 2016-01-30)