Psychiatry - Research Publications

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http://hdl.handle.net/11343/232

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Cortical and Subcortical Neuroanatomical Signatures of Schizotypy in 2,952 Individuals Assessed in a Worldwide ENIGMA Study

Kirschner, M ; Hodzic-Santor, B ; Antoniades, M ; Nenadic, I ; Kircher, T ; Krug, A ; Fornito, A ; Arnatkeviciute, A ; Dannlowski, U ; DeRosse, P ; Baune, BT ; Green, M ; Quide, Y ; Pantelis, C ; Chan, R ; Ettinger, U ; Debbane, M ; Derome, M ; Gaser, C ; Besteher, B ; Diederen, K ; Spencer, TJ ; Fletcher, P ; Roessler, W ; Kumari, V ; Park, H ; Lemmers-Jansen, I ; Gilleen, J ; Allen, P ; Marsman, J-B ; Lebedeva, I ; Kaiser, S ; Fett, A-K ; Sommer, I ; Lariviere, S ; Bernhardt, BC ; Dagher, A ; van Erp, TGM ; Turner, JA ; Thompson, PM ; Aleman, A (ELSEVIER SCIENCE INC, 2021-05-01)
Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study

Kirschner, M ; Hodzic-Santor, B ; Antoniades, M ; Nenadic, I ; Kircher, T ; Krug, A ; Meller, T ; Grotegerd, D ; Fornito, A ; Arnatkeviciute, A ; Bellgrove, MA ; Tiego, J ; Dannlowski, U ; Koch, K ; Huelsmann, C ; Kugel, H ; Enneking, V ; Klug, M ; Leehr, EJ ; Boehnlein, J ; Gruber, M ; Mehler, D ; DeRosse, P ; Moyett, A ; Baune, BT ; Green, M ; Quide, Y ; Pantelis, C ; Chan, R ; Wang, Y ; Ettinger, U ; Debbane, M ; Derome, M ; Gaser, C ; Besteher, B ; Diederen, K ; Spencer, TJ ; Fletcher, P ; Roessler, W ; Smigielski, L ; Kumari, V ; Premkumar, P ; Park, HRP ; Wiebels, K ; Lemmers-Jansen, I ; Gilleen, J ; Allen, P ; Kozhuharova, P ; Marsman, J-B ; Lebedeva, I ; Tomyshev, A ; Mukhorina, A ; Kaiser, S ; Fett, A-K ; Sommer, I ; Schuite-Koops, S ; Paquola, C ; Lariviere, S ; Bernhardt, B ; Dagher, A ; Grant, P ; van Erp, TGM ; Turner, JA ; Thompson, PM ; Aleman, A ; Modinos, G (SPRINGERNATURE, 2021-10-27)

Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, and compared these patterns with neuroanatomical abnormalities observed in major psychiatric disorders. The sample comprised 3004 unmedicated healthy individuals (12-68 years, 46.5% male) from 29 cohorts of the worldwide ENIGMA Schizotypy working group. Cortical and subcortical effect size maps with schizotypy scores were generated using standardized methods. Pattern similarities were assessed between the schizotypy-related cortical and subcortical maps and effect size maps from comparisons of schizophrenia (SZ), bipolar disorder (BD) and major depression (MDD) patients with controls. Thicker right medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC) was associated with higher schizotypy scores (r = 0.067, pFDR = 0.02). The cortical thickness profile in schizotypy was positively correlated with cortical abnormalities in SZ (r = 0.285, pspin = 0.024), but not BD (r = 0.166, pspin = 0.205) or MDD (r = -0.274, pspin = 0.073). The schizotypy-related subcortical volume pattern was negatively correlated with subcortical abnormalities in SZ (rho = -0.690, pspin = 0.006), BD (rho = -0.672, pspin = 0.009), and MDD (rho = -0.692, pspin = 0.004). Comprehensive mapping of schizotypy-related brain morphometry in the general population revealed a significant relationship between higher schizotypy and thicker mOFC/vmPFC, in the absence of confounding effects due to antipsychotic medication or disease chronicity. The cortical pattern similarity between schizotypy and schizophrenia yields new insights into a dimensional neurobiological continuity across the extended psychosis phenotype.
FRONTOSTRIATAL CONNECTIVITY IN TREATMENT-RESISTANT SCHIZOPHRENIA: RELATIONSHIP TO POSITIVE SYMPTOMS AND COGNITIVE FLEXIBILITY

Cropley, V ; Ganella, E ; Wannan, C ; Zalesky, A ; Van Rheenen, T ; Bousman, C ; Everall, I ; Fornito, A ; Pantelis, C (OXFORD UNIV PRESS, 2018-04-01)
S94. PREDICTION OF CANNABIS RELAPSE IN CLINICAL HIGH-RISK INDIVIDUALS AND RECENT ONSET PSYCHOSIS - PRELIMINARY RESULTS FROM THE PRONIA STUDY

Penzel, N ; Sanfelici, R ; Betz, L ; Antonucci, L ; Falkai, P ; Upthegrove, R ; Bertolino, A ; Borgwardt, S ; Brambilla, P ; Lencer, R ; Meisenzahl, E ; Ruhrmann, S ; Salokangas, RKR ; Pantelis, C ; Schultze-Lutter, F ; Wood, S ; Koutsouleris, N ; Kambeitz, J (Oxford University Press (OUP), 2020-05-18)
S12. A MACHINE LEARNING FRAMEWORK FOR ROBUST AND RELIABLE PREDICTION OF SHORT- AND LONG-TERM CLINICAL RESPONSE IN INITIALLY ANTIPSYCHOTIC-NAïVE SCHIZOPHRENIA PATIENTS BASED ON MULTIMODAL NEUROPSYCHIATRIC DATA

Ambrosen, KS ; Skjerbæk, MW ; Foldager, J ; Axelsen, MC ; Bak, N ; Arvastson, L ; Christensen, SR ; Johansen, LB ; Raghava, JM ; Oranje, B ; Rostrup, E ; Nielsen, MØ ; Osler, M ; Fagerlund, B ; Pantelis, C ; Kinon, BJ ; Glenthøj, BY ; Hansen, LK ; Ebdrup, BH (Oxford University Press (OUP), 2020-05-18)
T223. MULTIVARIATE PREDICTION OF FOLLOW UP SOCIAL AND OCCUPATIONAL OUTCOME IN CLINICAL HIGH-RISK INDIVIDUALS BASED ON GRAY MATTER VOLUMES AND HISTORY OF ENVIRONMENTAL ADVERSE EVENTS

Antonucci, L ; Pigoni, A ; Sanfelici, R ; Kambeitz-Ilankovic, L ; Dwyer, D ; Ruef, A ; Chisholm, K ; Haidl, T ; Rosen, M ; Kambeitz, J ; Ruhrmann, S ; Schultze-Lutter, F ; Falkai, P ; Lencer, R ; Dannlowski, U ; Upthegrove, R ; Salokangas, R ; Pantelis, C ; Meisenzahl, E ; Wood, S ; Brambilla, P ; Borgwardt, S ; Bertolino, A ; Koutsouleris, N (Oxford University Press (OUP), 2020-05-18)
T162. THICKER PREFRONTAL CORTEX IS ASSOCIATED WITH SUBCLINICAL NEGATIVE SYMPTOMS IN SCHIZOTYPY - AN ENIGMA CONSORTIUM META-ANALYSIS

Kirschner, M ; Hodzic-Santor, B ; Kircher, T ; Nenadic, I ; Fornito, A ; Green, M ; Quide, Y ; Pantelis, C ; Dannlowski, U ; DeRosse, P ; Chan, R ; Debbané, M ; Rössler, W ; Lebedeva, I ; Park, H ; Marsman, J-B ; Gilleen, J ; Fett, A-K ; van Erp, T ; Turner, J ; Thompson, P ; Aleman, A ; Modinos, G ; Kaiser, S (Oxford University Press (OUP), 2020-05-18)
T60. GENETIC INFLUENCES ON MEMORY FUNCTIONS AND RELATED BRAIN STRUCTURES AND ASSOCIATIONS WITH SCHIZOPHRENIA SPECTRUM DISORDERS: A NATION-WIDE TWIN STUDY

Lemvigh, C ; Brouwer, R ; Baruel Johansen, L ; Hilker, R ; Pantelis, C ; Glenthoj, B ; Fagerlund, B (Oxford University Press (OUP), 2020-05-18)
T21. DEVELOPMENT OF PROTEOMIC PREDICTION MODELS FOR OUTCOMES IN THE CLINICAL HIGH RISK STATE AND PSYCHOTIC EXPERIENCES IN ADOLESCENCE: MACHINE LEARNING ANALYSES IN TWO NESTED CASE-CONTROL STUDIES

Mongan, D ; Föcking, M ; Healy, C ; Raj Susai, S ; Cagney, G ; Cannon, M ; Zammit, S ; Nelson, B ; McGorry, P ; Nordentoft, M ; Krebs, M-O ; Riecher-Rössler, A ; Bressan, R ; Barrantes-Vidal, N ; Borgwardt, S ; Ruhrmann, S ; Sachs, G ; Van der Gaag, M ; Rutten, B ; Pantelis, C ; De Haan, L ; Valmaggia, L ; Kempton, M ; McGuire, P ; Cotter, D (Oxford University Press (OUP), 2020-05-18)
T18. EFFECTS OF COGNITIVE REMEDIATION ON WHITE MATTER IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS – A RANDOMIZED, CONTROLLED CLINICAL TRIAL

Kristensen, T ; Ebdrup, BH ; Hjorthøj, C ; Mandl, RCW ; Mitta Raghava, J ; Møllegaard Jepsen, JR ; Fagerlund, B ; Glenthøj, LB ; Wenneberg, C ; Krakauer, K ; Pantelis, C ; Glenthøj, BY ; Nordentoft, M (Oxford University Press (OUP), 2020-05-18)

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