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ItemGlobal, regional, and national mortality among young people aged 10-24 years, 1950-2019: a systematic analysis for the Global Burden of Disease Study 2019Ward, JL ; Azzopardi, PS ; Francis, KL ; Santelli, JS ; Skirbekk, V ; Sawyer, SM ; Kassebaum, NJ ; Mokdad, AH ; Hay, SI ; Abd-Allah, F ; Abdoli, A ; Abdollahi, M ; Abedi, A ; Abolhassani, H ; Abreu, LG ; Abrigo, MRM ; Abu-Gharbieh, E ; Abushouk, AI ; Adebayo, OM ; Adekanmbi, V ; Adham, D ; Advani, SM ; Afshari, K ; Agrawal, A ; Ahmad, T ; Ahmadi, K ; Ahmed, AE ; Aji, B ; Akombi-Inyang, B ; Alahdab, F ; Al-Aly, Z ; Alam, K ; Alanezi, FM ; Alanzi, TM ; Alcalde-Rabanal, JE ; Alemu, BW ; Al-Hajj, S ; Alhassan, RK ; Ali, S ; Alicandro, G ; Alijanzadeh, M ; Aljunid, SM ; Almasi-Hashiani, A ; Almasri, NA ; Al-Mekhlafi, HM ; Alonso, J ; Al-Raddadi, RM ; Altirkawi, KA ; Alvis-Guzman, N ; Amare, AT ; Amini, S ; Aminorroaya, A ; Amit, AML ; Amugsi, DA ; Ancuceanu, R ; Anderlini, D ; Andrei, CL ; Androudi, S ; Ansari, F ; Ansari, I ; Antonio, CAT ; Anvari, D ; Anwer, R ; Appiah, SCY ; Arabloo, J ; Arab-Zozani, M ; Arnlov, J ; Asaad, M ; Asadi-Aliabadi, M ; Asadi-Pooya, AA ; Atout, MMW ; Ausloos, M ; Avenyo, EK ; Avila-Burgos, L ; Quintanilla, BPA ; Ayano, G ; Aynalem, YA ; Azari, S ; Azene, ZN ; Bakhshaei, MH ; Bakkannavar, SM ; Banach, M ; Banik, PC ; Barboza, MA ; Barker-Collo, SL ; Baernighausen, TW ; Basu, S ; Baune, BT ; Bayati, M ; Bedi, N ; Beghi, E ; Bekuma, TT ; Bell, AW ; Bell, ML ; Benjet, C ; Bensenor, IM ; Berhe, AK ; Berhe, K ; Berman, AE ; Bhagavathula, AS ; Bhardwaj, N ; Bhardwaj, P ; Bhattacharyya, K ; Bhattarai, S ; Bhutta, ZA ; Bijani, A ; Bikbov, B ; Biondi, A ; Birhanu, TTM ; Biswas, RK ; Bohlouli, S ; Bolla, SR ; Boloor, A ; Borschmann, R ; Boufous, S ; Bragazzi, NL ; Braithwaite, D ; Breitborde, NJK ; Brenner, H ; Britton, GB ; Burns, RA ; Nagaraja, SB ; Butt, ZA ; dos Santos, FLC ; Camera, LA ; Campos-Nonato, IR ; Campuzano Rincon, JC ; Cardenas, R ; Carreras, G ; Carrero, JJ ; Carvalho, F ; Castaldelli-Maia, JM ; Castaneda-Orjuela, CA ; Castelpietra, G ; Catala-Lopez, F ; Cerin, E ; Chandan, JS ; Chang, H-Y ; Chang, J-C ; Charan, J ; Chattu, VK ; Chaturvedi, S ; Choi, J-YJ ; Chowdhury, MAK ; Christopher, DJ ; Dinh-Toi, C ; Chung, MT ; Chung, S-C ; Cicuttini, FM ; Constantin, TV ; Costa, VM ; Dahlawi, SMA ; Dai, H ; Dai, X ; Damiani, G ; Dandona, L ; Dandona, R ; Daneshpajouhnejad, P ; Darwesh, AM ; Alberto Davila-Cervantes, C ; Davletov, K ; De la Hoz, FP ; De Leo, D ; Dervenis, N ; Desai, R ; Desalew, A ; Deuba, K ; Dharmaratne, SD ; Dhungana, GP ; Dianatinasab, M ; da Silva, DD ; Diaz, D ; Didarloo, A ; Djalalinia, S ; Dorostkar, F ; Doshi, CP ; Doshmangir, L ; Doyle, KE ; Duraes, AR ; Kalan, ME ; Ebtehaj, S ; Edvardsson, D ; El Tantawi, M ; Elgendy, IY ; El-Jaafary, SI ; Elsharkawy, A ; Eshrati, B ; Eskandarieh, S ; Esmaeilnejad, S ; Esmaeilzadeh, F ; Esteghamati, S ; Faro, A ; Farzadfar, F ; Fattahi, N ; Feigin, VL ; Ferede, TY ; Fereshtehnejad, S-M ; Fernandes, E ; Ferrara, P ; Filip, I ; Fischer, F ; Fisher, JL ; Foigt, NA ; Folayan, MO ; Fomenkov, AA ; Foroutan, M ; Fukumoto, T ; Gad, MM ; Gaidhane, AM ; Gallus, S ; Gebre, T ; Gebremedhin, KB ; Gebremeskel, GG ; Gebremeskel, L ; Gebreslassie, AA ; Gesesew, HA ; Ghadiri, K ; Ghafourifard, M ; Ghamari, F ; Ghashghaee, A ; Gilani, SA ; Gnedovskaya, EV ; Godinho, MA ; Golechha, M ; Goli, S ; Gona, PN ; Gopalani, SV ; Gorini, G ; Grivna, M ; Gubari, MIM ; Gugnani, HC ; Guimaraes, RA ; Guo, Y ; Gupta, R ; Haagsma, JA ; Hafezi-Nejad, N ; Haile, TG ; Haj-Mirzaian, A ; Haj-Mirzaian, A ; Hall, BJ ; Hamadeh, RR ; Abdullah, KH ; Hamidi, S ; Handiso, DW ; Hanif, A ; Hankey, GJ ; Haririan, H ; Maria Haro, J ; Hasaballah, AI ; Hashi, A ; Hassan, A ; Hassanipour, S ; Hassankhani, H ; Hayat, K ; Heidari-Soureshjani, R ; Herteliu, C ; Heydarpour, F ; Ho, HC ; Hole, MK ; Holla, R ; Hoogar, P ; Hosseini, M ; Hosseinzadeh, M ; Hostiuc, M ; Hostiuc, S ; Househ, M ; Hsairi, M ; Huda, TM ; Humayun, A ; Hussain, R ; Hwang, B-F ; Iavicoli, I ; Ibitoye, SE ; Ilesanmi, OS ; Ilic, IM ; Ilic, MD ; Inbaraj, LR ; Intarut, N ; Iqbal, U ; Irvani, SSN ; Islam, MM ; Islam, SMS ; Iso, H ; Ivers, RQ ; Jahani, MA ; Jakovljevic, M ; Jalali, A ; Janodia, MD ; Javaheri, T ; Jeemon, P ; Jenabi, E ; Jha, RP ; Jha, V ; Ji, JS ; Jonas, JB ; Jones, KM ; Joukar, F ; Jozwiak, JJ ; Juliusson, PB ; Jurisson, M ; Kabir, A ; Kabir, Z ; Kalankesh, LR ; Kalhor, R ; Kamyari, N ; Kanchan, T ; Karch, A ; Karimi, SE ; Kaur, S ; Kayode, GA ; Keiyoro, PN ; Khalid, N ; Khammarnia, M ; Khan, M ; Khan, MN ; Khatab, K ; Khater, MM ; Khatib, MN ; Khayamzadeh, M ; Khazaie, H ; Khoja, AT ; Kieling, C ; Kim, Y-E ; Kim, YJ ; Kimokoti, RW ; Kisa, A ; Kisa, S ; Kivimaki, M ; Koolivand, A ; Kosen, S ; Koyanagi, A ; Krishan, K ; Kugbey, N ; Kumar, GA ; Kumar, M ; Kumar, N ; Kurmi, OP ; Kusuma, D ; La Vecchia, C ; Lacey, B ; Lal, DK ; Lalloo, R ; Lan, Q ; Landires, I ; Lansingh, VC ; Larsson, AO ; Lasrado, S ; Lassi, ZS ; Lauriola, P ; Lee, PH ; Lee, SWH ; Leigh, J ; Leonardi, M ; Leung, J ; Levi, M ; Lewycka, S ; Li, B ; Li, M-C ; Li, S ; Lim, L-L ; Lim, SS ; Liu, X ; Lorkowski, S ; Lotufo, PA ; Lunevicius, R ; Maddison, R ; Mahasha, PW ; Mahdavi, MM ; Mahmoudi, M ; Majeed, A ; Maleki, A ; Malekzadeh, R ; Malta, DC ; Mamun, AA ; Mansouri, B ; Mansournia, MA ; Martinez, G ; Martinez-Raga, J ; Martins-Melo, FR ; Mason-Jones, AJ ; Masoumi, SZ ; Mathur, MR ; Maulik, PK ; McGrath, JJ ; Mehndiratta, MM ; Mehri, F ; Memiah, PTN ; Mendoza, W ; Menezes, RG ; Mengesha, EW ; Meretoja, A ; Meretoja, TJ ; Mestrovic, T ; Miazgowski, B ; Miazgowski, T ; Michalek, IM ; Miller, TR ; Mini, GK ; Mirica, A ; Mirrakhimov, EM ; Mirzaei, H ; Mirzaei, M ; Moazen, B ; Mohammad, DK ; Mohammadi, S ; Mohammadian-Hafshejani, A ; Mohammadifard, N ; Mohammadpourhodki, R ; Mohammed, S ; Monasta, L ; Moradi, G ; Moradi-Lakeh, M ; Moradzadeh, R ; Moraga, P ; Morrison, SD ; Mosapour, A ; Khaneghah, AM ; Mueller, UO ; Muriithi, MK ; Murray, CJL ; Muthupandian, S ; Naderi, M ; Nagarajan, AJ ; Naghavi, M ; Naimzada, MD ; Nangia, V ; Nayak, VC ; Nazari, J ; Ndejjo, R ; Negoi, I ; Negoi, RI ; Netsere, HB ; Nguefack-Tsague, G ; Diep, NN ; Huong, LTN ; Nie, J ; Ningrum, DNA ; Nnaji, CA ; Nomura, S ; Noubiap, JJ ; Nowak, C ; Nunez-Samudio, V ; Ogbo, FA ; Oghenetega, OB ; Oh, I-H ; Oladnabi, M ; Olagunju, AT ; Olusanya, BO ; Olusanya, JO ; Bali, AO ; Omer, MO ; Onwujekwe, OE ; Ortiz, A ; Otoiu, A ; Otstavnov, N ; Otstavnov, SS ; Overland, S ; Owolabi, MO ; Mahesh, PA ; Padubidri, JR ; Pakshir, K ; Palladino, R ; Pana, A ; Panda-Jonas, S ; Pandey, A ; Able Panelo, CI ; Park, E-K ; Patten, SB ; Peden, AE ; Filipino Pepito, VC ; Peprah, EK ; Pereira, J ; Pesudovs, K ; Hai, QP ; Phillips, MR ; Piradov, MA ; Pirsaheb, M ; Postma, MJ ; Pottoo, FH ; Pourjafar, H ; Pourshams, A ; Prada, SI ; Pupillo, E ; Syed, ZQ ; Rabiee, MH ; Rabiee, N ; Radfar, A ; Rafiee, A ; Raggi, A ; Rahim, F ; Rahimi-Movaghar, V ; Rahman, MHU ; Rahman, MA ; Ramezanzadeh, K ; Ranabhat, CL ; Rao, SJ ; Rashedi, V ; Rastogi, P ; Rathi, P ; Rawaf, DL ; Rawaf, S ; Rawal, L ; Rawassizadeh, R ; Renzaho, AMN ; Rezaei, N ; Rezaei, N ; Rezai, MS ; Riahi, SM ; Rickard, J ; Roever, L ; Ronfani, L ; Roth, GA ; Rubagotti, E ; Rumisha, SF ; Rwegerera, GM ; Sabour, S ; Sachdev, PS ; Saddik, B ; Sadeghi, E ; Moghaddam, SS ; Sagar, R ; Sahebkar, A ; Sahraian, MA ; Sajadi, SM ; Salem, MR ; Salimzadeh, H ; Samy, AM ; Sanabria, J ; Santric-Milicevic, MM ; Saraswathy, SYI ; Sarrafzadegan, N ; Sarveazad, A ; Sathish, T ; Sattin, D ; Saxena, D ; Saxena, S ; Schiavolin, S ; Schwebel, DC ; Schwendicke, F ; Senthilkumaran, S ; Sepanlou, SG ; Sha, F ; Shafaat, O ; Shahabi, S ; Shaheen, AA ; Shaikh, MA ; Shakiba, S ; Shamsi, MB ; Shannawaz, M ; Sharafi, K ; Sheikh, A ; Sheikhbahaei, S ; Shetty, BSK ; Shi, P ; Shigematsu, M ; Shin, JI ; Shiri, R ; Shuval, K ; Siabani, S ; Sigfusdottir, ID ; Sigurvinsdottir, R ; Santos Silva, DA ; Silva, JP ; Simonetti, B ; Singh, JA ; Singh, V ; Sinke, AH ; Skryabin, VY ; Slater, H ; Smith, EUR ; Sobhiyeh, MR ; Sobngwi, E ; Soheili, A ; Somefun, OD ; Sorrie, MB ; Soyiri, IN ; Sreeramareddy, CT ; Stein, DJ ; Stokes, MA ; Sudaryanto, A ; Sultan, I ; Tabares-Seisdedos, R ; Tabuchi, T ; Tadakamadla, SK ; Taherkhani, A ; Tamiru, AT ; Tareque, MI ; Thankappan, KR ; Thapar, R ; Thomas, N ; Titova, MV ; Tonelli, M ; Tovani-Palone, MR ; Bach, XT ; Travillian, RS ; Tsai, AC ; Tsatsakis, A ; Car, LT ; Uddin, R ; Unim, B ; Unnikrishnan, B ; Upadhyay, E ; Vacante, M ; Tahbaz, SV ; Valdez, PR ; Varughese, S ; Vasankari, TJ ; Venketasubramanian, N ; Villeneuve, PJ ; Violante, FS ; Vlassov, V ; Vos, T ; Giang, TV ; Waheed, Y ; Wamai, RG ; Wang, Y ; Wang, Y ; Wang, Y-P ; Westerman, R ; Wickramasinghe, ND ; Wu, A-M ; Wu, C ; Jabbari, SHY ; Yamagishi, K ; Yano, Y ; Yaya, S ; Yazdi-Feyzabadi, V ; Yeshitila, YG ; Yip, P ; Yonemoto, N ; Yoon, S-J ; Younis, MZ ; Yousefinezhadi, T ; Yu, C ; Yu, Y ; Yuce, D ; Zaidi, SS ; Bin Zaman, S ; Zamani, M ; Zamanian, M ; Zarafshan, H ; Zarei, A ; Zastrozhin, MS ; Zhang, Y ; Zhang, Z-J ; Zhao, X-JG ; Zhu, C ; Patton, GC ; Viner, RM (ELSEVIER SCIENCE INC, 2021-10-30)BACKGROUND: Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of deaths, years of life lost, and mortality rates by sex and age group in people aged 10-24 years in 204 countries and territories from 1950 to 2019 by use of estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. METHODS: We report trends in estimated total numbers of deaths and mortality rate per 100 000 population in young people aged 10-24 years by age group (10-14 years, 15-19 years, and 20-24 years) and sex in 204 countries and territories between 1950 and 2019 for all causes, and between 1980 and 2019 by cause of death. We analyse variation in outcomes by region, age group, and sex, and compare annual rate of change in mortality in young people aged 10-24 years with that in children aged 0-9 years from 1990 to 2019. We then analyse the association between mortality in people aged 10-24 years and socioeconomic development using the GBD Socio-demographic Index (SDI), a composite measure based on average national educational attainment in people older than 15 years, total fertility rate in people younger than 25 years, and income per capita. We assess the association between SDI and all-cause mortality in 2019, and analyse the ratio of observed to expected mortality by SDI using the most recent available data release (2017). FINDINGS: In 2019 there were 1·49 million deaths (95% uncertainty interval 1·39-1·59) worldwide in people aged 10-24 years, of which 61% occurred in males. 32·7% of all adolescent deaths were due to transport injuries, unintentional injuries, or interpersonal violence and conflict; 32·1% were due to communicable, nutritional, or maternal causes; 27·0% were due to non-communicable diseases; and 8·2% were due to self-harm. Since 1950, deaths in this age group decreased by 30·0% in females and 15·3% in males, and sex-based differences in mortality rate have widened in most regions of the world. Geographical variation has also increased, particularly in people aged 10-14 years. Since 1980, communicable and maternal causes of death have decreased sharply as a proportion of total deaths in most GBD super-regions, but remain some of the most common causes in sub-Saharan Africa and south Asia, where more than half of all adolescent deaths occur. Annual percentage decrease in all-cause mortality rate since 1990 in adolescents aged 15-19 years was 1·3% in males and 1·6% in females, almost half that of males aged 1-4 years (2·4%), and around a third less than in females aged 1-4 years (2·5%). The proportion of global deaths in people aged 0-24 years that occurred in people aged 10-24 years more than doubled between 1950 and 2019, from 9·5% to 21·6%. INTERPRETATION: Variation in adolescent mortality between countries and by sex is widening, driven by poor progress in reducing deaths in males and older adolescents. Improving global adolescent mortality will require action to address the specific vulnerabilities of this age group, which are being overlooked. Furthermore, indirect effects of the COVID-19 pandemic are likely to jeopardise efforts to improve health outcomes including mortality in young people aged 10-24 years. There is an urgent need to respond to the changing global burden of adolescent mortality, address inequities where they occur, and improve the availability and quality of primary mortality data in this age group. FUNDING: Bill & Melinda Gates Foundation.
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ItemMeasuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019Lozano, R ; Fullman, N ; Mumford, JE ; Knight, M ; Barthelemy, CM ; Abbafati, C ; Abbastabar, H ; Abd-Allah, F ; Abdollahi, M ; Abedi, A ; Abolhassani, H ; Abosetugn, AE ; Abreu, LG ; Abrigo, MRM ; Abu Haimed, AK ; Abushouk, AI ; Adabi, M ; Adebayo, OM ; Adekanmbi, V ; Adelson, JD ; Adetokunboh, OO ; Adham, D ; Advani, SM ; Afshin, A ; Agarwal, G ; Agasthi, P ; Aghamir, SMK ; Agrawal, A ; Ahmad, T ; Akinyemi, RO ; Alahdab, F ; Al-Aly, Z ; Alam, K ; Albertson, SB ; Alemu, YM ; Alhassan, RK ; Ali, M ; Ali, S ; Alipour, V ; Aljunid, SM ; Alla, F ; Almadi, MAH ; Almasi, A ; Almasi-Hashiani, A ; Almasri, NA ; Al-Mekhlafi, HM ; Almulhim, AM ; Alonso, J ; Al-Raddadi, RM ; Altirkawi, KA ; Alvis-Guzman, N ; Alvis-Zakzuk, NJ ; Amini, S ; Amini-Rarani, M ; Amiri, F ; Amit, AML ; Amugsi, DA ; Ancuceanu, R ; Anderlini, D ; Andrei, CL ; Androudi, S ; Ansari, F ; Ansari-Moghaddam, A ; Antonio, CAT ; Antony, CM ; Antriyandarti, E ; Anvari, D ; Anwer, R ; Arabloo, J ; Arab-Zozani, M ; Aravkin, AY ; Aremu, O ; Arnlov, J ; Asaad, M ; Asadi-Aliabadi, M ; Asadi-Pooya, AA ; Ashbaugh, C ; Athari, SS ; Atout, MMW ; Ausloos, M ; Avila-Burgos, L ; Quintanilla, BPA ; Ayano, G ; Ayanore, MA ; Aynalem, GL ; Aynalem, YA ; Ayza, MA ; Azari, S ; Azzopardi, PS ; Darshan, BB ; Babaee, E ; Badiye, AD ; Bahrami, MA ; Babaee, E ; Badiye, AD ; Bahrami, MA ; Baig, AA ; Bakhshaei, MH ; Bakhtiari, A ; Bakkannavar, SM ; Balachandran, A ; Balassyano, S ; Banach, M ; Banerjee, SK ; Banik, PC ; Bante, AB ; Bante, SA ; Barker-Collo, SL ; Barnighausen, TW ; Barrero, LH ; Bassat, Q ; Basu, S ; Baune, BT ; Bayati, M ; Baye, BA ; Bedi, N ; Beghi, E ; Behzadifar, M ; Bekuma, TTT ; Bell, ML ; Bensenor, IM ; Berman, AE ; Bernabe, E ; Bernstein, RS ; Bhagavathula, AS ; Bhandari, D ; Bhardwaj, P ; Bhat, AG ; Bhattacharyya, K ; Bhattarai, S ; Bhutta, ZA ; Bijani, A ; Bikbov, B ; Bilano, V ; Biondi, A ; Birihane, BM ; Bockarie, MJ ; Bohlouli, S ; Bojia, HA ; Bolla, SRR ; Boloor, A ; Brady, OJ ; Braithwaite, D ; Briant, PS ; Briggs, AM ; Briko, NI ; Nagaraja, SB ; Busse, R ; Butt, ZA ; Luciano Caetano dos Santos, F ; Cahuana-Hurtado, L ; Camera, LA ; Cardenas, R ; Carreras, G ; Carrero, JJ ; Carvalho, F ; Castaldelli-Maia, JM ; Castaneda-Orjuela, CA ; Castelpietra, G ; Castro, F ; Catala-Lopez, F ; Causey, K ; Cederroth, CR ; Cercy, KM ; Cerin, E ; Chandan, JS ; Chang, AY ; Charan, J ; Chattu, VK ; Chaturvedi, S ; Chin, KL ; Cho, DY ; Choi, J-YJ ; Christensen, H ; Chu, D-T ; Chung, MT ; Ciobanu, LG ; Cirillo, M ; Comfort, H ; Compton, K ; Cortesi, PA ; Costa, VM ; Cousin, E ; Dahlawi, SMA ; Damiani, G ; Dandona, L ; Dandona, R ; Gela, JD ; Darwesh, AM ; Daryani, A ; Dash, AP ; Davey, G ; Davila-Cervantes, CA ; Davletov, K ; De Neve, J-W ; Denova-Gutierrez, E ; Deribe, K ; Dervenis, N ; Desai, R ; Dharmaratne, SD ; Dhungana, GP ; Dianatinasab, M ; da Silva, DD ; Diaz, D ; Dippenaar, IN ; Hoa, TD ; Dorostkar, F ; Doshmangir, L ; Duncan, BB ; Duraes, AR ; Eagan, AW ; Edvardsson, D ; El Sayed, I ; El Tantawi, M ; Elgendy, IY ; Elyazar, IRF ; Eskandari, K ; Eskandarieh, S ; Esmaeilnejad, S ; Esteghamati, A ; Ezekannagha, O ; Farag, T ; Farahmand, M ; Faraon, EJA ; Sofia e Sa Farinha, C ; Farioli, A ; Faris, PS ; Faro, A ; Fazlzadeh, M ; Feigin, VL ; Fernandes, E ; Ferrara, P ; Feyissa, GT ; Filip, I ; Fischer, F ; Fisher, JL ; Flor, LS ; Foigt, NA ; Folayan, MO ; Fomenkov, AA ; Foroutan, M ; Francis, JM ; Fu, W ; Fukumoto, T ; Furtado, JM ; Gad, MM ; Gaidhane, AM ; Gakidou, E ; Galles, NC ; Gallus, S ; Gardner, WM ; Geberemariyam, BS ; Gebrehiwot, AM ; Gebremeskel, GG ; Gebremeskel, LG ; Gesesew, HA ; Ghadiri, K ; Ghafourifard, M ; Ghashghaee, A ; Ghith, N ; Gholamian, A ; Gilani, SA ; Gill, PS ; Gill, TK ; Ginindza, TG ; Gitimoghaddam, M ; Giussani, G ; Glagn, M ; Gnedovskaya, EV ; Godinho, MA ; Goharinezhad, S ; Gopalani, SV ; Goudarzian, AH ; Goulart, BNG ; Gubari, MIM ; Guimaraes, RA ; Guled, RA ; Gultie, T ; Guo, Y ; Gupta, R ; Gupta, R ; Hafezi-Nejad, N ; Hafiz, A ; Haile, TG ; Hamadeh, RR ; Hameed, S ; Hamidi, S ; Han, C ; Han, H ; Handiso, DW ; Hanif, A ; Hankey, GJ ; Haro, JM ; Hasaballah, AI ; Hasan, MM ; Hashi, A ; Hassan, A ; Hassan, S ; Hassanipour, S ; Hassankhani, H ; Havmoeller, RJ ; Hay, SI ; Hayat, K ; Heidari, G ; Heidari-Soureshjani, R ; Hendrie, D ; Herteliu, C ; Hird, TR ; Ho, HC ; Hole, MK ; Holla, R ; Hoogar, P ; Hopf, KP ; Horita, N ; Hossain, N ; Hosseini, M ; Hosseinzadeh, M ; Hostiuc, M ; Hostiuc, S ; Househ, M ; Hsieh, VC-R ; Hu, G ; Huda, TM ; Humayun, A ; Hwang, B-F ; Iavicoli, I ; Ibitoye, SE ; Ikeda, N ; Ilesanmi, OS ; Ilic, IM ; Ilic, MD ; Inbaraj, LR ; Iqbal, U ; Irvani, SSN ; Irvine, CMS ; Islam, MM ; Islam, SMS ; Islami, F ; Iso, H ; Iwu, CCD ; Iwu, CJ ; Jaafari, J ; Jadidi-Niaragh, F ; Jafarinia, M ; Jahagirdar, D ; Jahani, MA ; Jahanmehr, N ; Jakovljevic, M ; Janjani, H ; Javaheri, T ; Jayatilleke, AU ; Jenabi, E ; Jha, RP ; Jha, V ; Ji, JS ; Jia, P ; John-Akinola, YO ; Jonas, JB ; Joukar, F ; Jozwiak, JJ ; Jurisson, M ; Kabir, Z ; Kalankesh, LR ; Kalhor, R ; Kamath, AM ; Kanchan, T ; Kapoor, N ; Matin, BK ; Karanikolos, M ; Karimi, SM ; Kassebaum, NJ ; Katikireddi, SV ; Kayode, GA ; Keiyoro, PN ; Khader, YS ; Khammarnia, M ; Khan, EA ; Khan, M ; Khang, Y-H ; Khatab, K ; Khater, AM ; Khater, MM ; Khatib, MN ; Khayamzadeh, M ; Khubchandani, J ; Kianipour, N ; Kim, Y-E ; Kim, YJ ; Kimokoti, RW ; Kinfu, Y ; Kisa, A ; Kissimova-Skarbek, K ; Kivimaki, M ; Kneib, CJ ; Kocarnik, JM ; Kochhar, S ; Kohler, S ; Kopec, JA ; Korotkova, AV ; Korshunov, VA ; Kosen, S ; Kotlo, A ; Koul, PA ; Koyanagi, A ; Krishan, K ; Krohn, KJ ; Kugbey, N ; Kulkarni, V ; Kumar, GA ; Kumar, M ; Kumar, N ; Kurmi, OP ; Kusuma, D ; Kyu, HH ; La Vecchia, C ; Lacey, B ; Lal, DK ; Lalloo, R ; Landires, I ; Lansingh, VC ; Larsson, AO ; Lasrado, S ; Lau, KM-M ; Lauriola, P ; Lazarus, JV ; Ledesma, JR ; Lee, PH ; Lee, SWH ; Leever, AT ; LeGrand, KE ; Leigh, J ; Leonardi, M ; Li, S ; Lim, L-L ; Lim, SS ; Liu, X ; Logroscino, G ; Lopez, AD ; Lopukhov, PD ; Lotufo, PA ; Lu, A ; Ma, J ; Madadin, M ; Mahasha, PW ; Mahmoudi, M ; Majeed, A ; Malagon-Rojas, JN ; Maleki, S ; Malta, DC ; Mansouri, B ; Mansournia, MA ; Martini, S ; Martins-Melo, FR ; Martopullo, I ; Massenburg, BB ; Mastrogiacomo, CI ; Mathur, MR ; McAlinden, C ; McKee, M ; Medina-Solis, CE ; Meharie, BG ; Mehndiratta, MM ; Nasab, EM ; Mehri, F ; Mehrotra, R ; Mekonnen, T ; Melese, A ; Memiah, PTN ; Mendoza, W ; Menezes, RG ; Mensah, GA ; Meretoja, A ; Meretoja, TJ ; Mestrovic, T ; Miazgowski, B ; Michalek, IM ; Mirrakhimov, EM ; Mirzaei, M ; Mirzaei-Alavijeh, M ; Mitchell, PB ; Moazen, B ; Moghadaszadeh, M ; Mohamadi, E ; Mohammad, DK ; Mohammad, Y ; Mezerji, NMG ; Mohammadian-Hafshejani, A ; Mohammed, JA ; Mohammed, S ; Mokdad, AH ; Monasta, L ; Mondello, S ; Moradi, M ; Moradi-Lakeh, M ; Moradzadeh, R ; Moraga, P ; 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Murray, CJL (ELSEVIER SCIENCE INC, 2020-10-17)BACKGROUND: Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's Thirteenth General Programme of Work (GPW13). Measuring effective coverage at the health-system level is important for understanding whether health services are aligned with countries' health profiles and are of sufficient quality to produce health gains for populations of all ages. METHODS: Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we assessed UHC effective coverage for 204 countries and territories from 1990 to 2019. Drawing from a measurement framework developed through WHO's GPW13 consultation, we mapped 23 effective coverage indicators to a matrix representing health service types (eg, promotion, prevention, and treatment) and five population-age groups spanning from reproductive and newborn to older adults (≥65 years). Effective coverage indicators were based on intervention coverage or outcome-based measures such as mortality-to-incidence ratios to approximate access to quality care; outcome-based measures were transformed to values on a scale of 0-100 based on the 2·5th and 97·5th percentile of location-year values. We constructed the UHC effective coverage index by weighting each effective coverage indicator relative to its associated potential health gains, as measured by disability-adjusted life-years for each location-year and population-age group. For three tests of validity (content, known-groups, and convergent), UHC effective coverage index performance was generally better than that of other UHC service coverage indices from WHO (ie, the current metric for SDG indicator 3.8.1 on UHC service coverage), the World Bank, and GBD 2017. We quantified frontiers of UHC effective coverage performance on the basis of pooled health spending per capita, representing UHC effective coverage index levels achieved in 2019 relative to country-level government health spending, prepaid private expenditures, and development assistance for health. To assess current trajectories towards the GPW13 UHC billion target-1 billion more people benefiting from UHC by 2023-we estimated additional population equivalents with UHC effective coverage from 2018 to 2023. FINDINGS: Globally, performance on the UHC effective coverage index improved from 45·8 (95% uncertainty interval 44·2-47·5) in 1990 to 60·3 (58·7-61·9) in 2019, yet country-level UHC effective coverage in 2019 still spanned from 95 or higher in Japan and Iceland to lower than 25 in Somalia and the Central African Republic. Since 2010, sub-Saharan Africa showed accelerated gains on the UHC effective coverage index (at an average increase of 2·6% [1·9-3·3] per year up to 2019); by contrast, most other GBD super-regions had slowed rates of progress in 2010-2019 relative to 1990-2010. Many countries showed lagging performance on effective coverage indicators for non-communicable diseases relative to those for communicable diseases and maternal and child health, despite non-communicable diseases accounting for a greater proportion of potential health gains in 2019, suggesting that many health systems are not keeping pace with the rising non-communicable disease burden and associated population health needs. In 2019, the UHC effective coverage index was associated with pooled health spending per capita (r=0·79), although countries across the development spectrum had much lower UHC effective coverage than is potentially achievable relative to their health spending. Under maximum efficiency of translating health spending into UHC effective coverage performance, countries would need to reach $1398 pooled health spending per capita (US$ adjusted for purchasing power parity) in order to achieve 80 on the UHC effective coverage index. From 2018 to 2023, an estimated 388·9 million (358·6-421·3) more population equivalents would have UHC effective coverage, falling well short of the GPW13 target of 1 billion more people benefiting from UHC during this time. Current projections point to an estimated 3·1 billion (3·0-3·2) population equivalents still lacking UHC effective coverage in 2023, with nearly a third (968·1 million [903·5-1040·3]) residing in south Asia. INTERPRETATION: The present study demonstrates the utility of measuring effective coverage and its role in supporting improved health outcomes for all people-the ultimate goal of UHC and its achievement. Global ambitions to accelerate progress on UHC service coverage are increasingly unlikely unless concerted action on non-communicable diseases occurs and countries can better translate health spending into improved performance. Focusing on effective coverage and accounting for the world's evolving health needs lays the groundwork for better understanding how close-or how far-all populations are in benefiting from UHC. FUNDING: Bill & Melinda Gates Foundation.