Psychiatry - Research Publications

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    Cortical and Subcortical Neuroanatomical Signatures of Schizotypy in 2,952 Individuals Assessed in a Worldwide ENIGMA Study
    Kirschner, M ; Hodzic-Santor, B ; Antoniades, M ; Nenadic, I ; Kircher, T ; Krug, A ; Fornito, A ; Arnatkeviciute, A ; Dannlowski, U ; DeRosse, P ; Baune, BT ; Green, M ; Quide, Y ; Pantelis, C ; Chan, R ; Ettinger, U ; Debbane, M ; Derome, M ; Gaser, C ; Besteher, B ; Diederen, K ; Spencer, TJ ; Fletcher, P ; Roessler, W ; Kumari, V ; Park, H ; Lemmers-Jansen, I ; Gilleen, J ; Allen, P ; Marsman, J-B ; Lebedeva, I ; Kaiser, S ; Fett, A-K ; Sommer, I ; Lariviere, S ; Bernhardt, BC ; Dagher, A ; van Erp, TGM ; Turner, JA ; Thompson, PM ; Aleman, A (ELSEVIER SCIENCE INC, 2021-05-01)
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    Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD working group
    Leerssen, J ; Blanken, TF ; Pozzi, E ; Jahanshad, N ; Aftanas, L ; Andreassen, OA ; Baune, BT ; Ching, CRK ; Dannlowski, U ; Frodl, T ; Godlewska, BR ; Gotlib, IH ; Grotegerd, D ; Gruber, O ; Hatton, SN ; Hickie, IB ; Jaworska, N ; Kircher, T ; Krug, A ; Lagopoulos, J ; Li, M ; MacMaster, FP ; McIntosh, AM ; Mwangi, B ; Osipov, E ; Portella, MJ ; Sacchet, MD ; Samann, PG ; Simulionyte, E ; Soares, JC ; Walter, M ; Whalley, HC ; Veltman, DJ ; Thompson, PM ; Schmaal, L ; Van Someren, EJW (WILEY, 2020-09)
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    Genome-wide association study of circulating interleukin 6 levels identifies novel loci
    Ahluwalia, TS ; Prins, BP ; Abdollahi, M ; Armstrong, NJ ; Aslibekyan, S ; Bain, L ; Jefferis, B ; Baumert, J ; Beekman, M ; Ben-Shlomo, Y ; Bis, JC ; Mitchell, BD ; de Geus, E ; Delgado, GE ; Marek, D ; Eriksson, J ; Kajantie, E ; Kanoni, S ; Kemp, JP ; Lu, C ; Marioni, RE ; McLachlan, S ; Milaneschi, Y ; Nolte, IM ; Petrelis, AM ; Porcu, E ; Sabater-Lleal, M ; Naderi, E ; Seppala, I ; Shah, T ; Singhal, G ; Standl, M ; Teumer, A ; Thalamuthu, A ; Thiering, E ; Trompet, S ; Ballantyne, CM ; Benjamin, EJ ; Casas, JP ; Toben, C ; Dedoussis, G ; Deelen, J ; Durda, P ; Engmann, J ; Feitosa, MF ; Grallert, H ; Hammarstedt, A ; Harris, SE ; Homuth, G ; Hottenga, J-J ; Jalkanen, S ; Jamshidi, Y ; Jawahar, MC ; Jess, T ; Kivimaki, M ; Kleber, ME ; Lahti, J ; Liu, Y ; Marques-Vidal, P ; Mellstrom, D ; Mooijaart, SP ; Muller-Nurasyid, M ; Penninx, B ; Revez, JA ; Rossing, P ; Raikkonen, K ; Sattar, N ; Scharnagl, H ; Sennblad, B ; Silveira, A ; St Pourcain, B ; Timpson, NJ ; Trollor, J ; van Dongen, J ; Van Heemst, D ; Visvikis-Siest, S ; Vollenweider, P ; Volker, U ; Waldenberger, M ; Willemsen, G ; Zabaneh, D ; Morris, RW ; Arnett, DK ; Baune, BT ; Boomsma, D ; Chang, Y-PC ; Deary, IJ ; Deloukas, P ; Eriksson, JG ; Evans, DM ; Ferreira, MA ; Gaunt, T ; Gudnason, V ; Hamsten, A ; Heinrich, J ; Hingorani, A ; Humphries, SE ; Jukema, JW ; Koenig, W ; Kumari, M ; Kutalik, Z ; Lawlor, DA ; Lehtimaki, T ; Marz, W ; Mather, KA ; Naitza, S ; Nauck, M ; Ohlsson, C ; Price, JF ; Raitakari, O ; Rice, K ; Sachdev, PS ; Slagboom, E ; Sorensen, TIA ; Spector, T ; Stacey, D ; Stathopoulou, MG ; Tanaka, T ; Wannamethee, SG ; Whincup, P ; Rotter, J ; Dehghan, A ; Boerwinkle, E ; Psaty, BM ; Snieder, H ; Alizadeh, BZ (OXFORD UNIV PRESS, 2021-03-01)
    Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 × 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcombined = 1.5 × 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (Pcombined = 1.2 × 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.