Psychiatry - Research Publications

Permanent URI for this collection

http://hdl.handle.net/11343/232

Filters

2020 - 2021 11
Reset filters

Settings
Statistics
Citations
Type: Abstract × Author: Pantelis, Christos × Start date: 2020 × End date: 2021 ×

Search Results

Now showing 1 - 10 of 11
  • Item
    No Preview Available
    Cortical and Subcortical Neuroanatomical Signatures of Schizotypy in 2,952 Individuals Assessed in a Worldwide ENIGMA Study
    Kirschner, M ; Hodzic-Santor, B ; Antoniades, M ; Nenadic, I ; Kircher, T ; Krug, A ; Fornito, A ; Arnatkeviciute, A ; Dannlowski, U ; DeRosse, P ; Baune, BT ; Green, M ; Quide, Y ; Pantelis, C ; Chan, R ; Ettinger, U ; Debbane, M ; Derome, M ; Gaser, C ; Besteher, B ; Diederen, K ; Spencer, TJ ; Fletcher, P ; Roessler, W ; Kumari, V ; Park, H ; Lemmers-Jansen, I ; Gilleen, J ; Allen, P ; Marsman, J-B ; Lebedeva, I ; Kaiser, S ; Fett, A-K ; Sommer, I ; Lariviere, S ; Bernhardt, BC ; Dagher, A ; van Erp, TGM ; Turner, JA ; Thompson, PM ; Aleman, A (ELSEVIER SCIENCE INC, 2021-05-01)
  • Item
    Thumbnail Image
    Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study
    Kirschner, M ; Hodzic-Santor, B ; Antoniades, M ; Nenadic, I ; Kircher, T ; Krug, A ; Meller, T ; Grotegerd, D ; Fornito, A ; Arnatkeviciute, A ; Bellgrove, MA ; Tiego, J ; Dannlowski, U ; Koch, K ; Huelsmann, C ; Kugel, H ; Enneking, V ; Klug, M ; Leehr, EJ ; Boehnlein, J ; Gruber, M ; Mehler, D ; DeRosse, P ; Moyett, A ; Baune, BT ; Green, M ; Quide, Y ; Pantelis, C ; Chan, R ; Wang, Y ; Ettinger, U ; Debbane, M ; Derome, M ; Gaser, C ; Besteher, B ; Diederen, K ; Spencer, TJ ; Fletcher, P ; Roessler, W ; Smigielski, L ; Kumari, V ; Premkumar, P ; Park, HRP ; Wiebels, K ; Lemmers-Jansen, I ; Gilleen, J ; Allen, P ; Kozhuharova, P ; Marsman, J-B ; Lebedeva, I ; Tomyshev, A ; Mukhorina, A ; Kaiser, S ; Fett, A-K ; Sommer, I ; Schuite-Koops, S ; Paquola, C ; Lariviere, S ; Bernhardt, B ; Dagher, A ; Grant, P ; van Erp, TGM ; Turner, JA ; Thompson, PM ; Aleman, A ; Modinos, G (SPRINGERNATURE, 2021-10-27)
    Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, and compared these patterns with neuroanatomical abnormalities observed in major psychiatric disorders. The sample comprised 3004 unmedicated healthy individuals (12-68 years, 46.5% male) from 29 cohorts of the worldwide ENIGMA Schizotypy working group. Cortical and subcortical effect size maps with schizotypy scores were generated using standardized methods. Pattern similarities were assessed between the schizotypy-related cortical and subcortical maps and effect size maps from comparisons of schizophrenia (SZ), bipolar disorder (BD) and major depression (MDD) patients with controls. Thicker right medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC) was associated with higher schizotypy scores (r = 0.067, pFDR = 0.02). The cortical thickness profile in schizotypy was positively correlated with cortical abnormalities in SZ (r = 0.285, pspin = 0.024), but not BD (r = 0.166, pspin = 0.205) or MDD (r = -0.274, pspin = 0.073). The schizotypy-related subcortical volume pattern was negatively correlated with subcortical abnormalities in SZ (rho = -0.690, pspin = 0.006), BD (rho = -0.672, pspin = 0.009), and MDD (rho = -0.692, pspin = 0.004). Comprehensive mapping of schizotypy-related brain morphometry in the general population revealed a significant relationship between higher schizotypy and thicker mOFC/vmPFC, in the absence of confounding effects due to antipsychotic medication or disease chronicity. The cortical pattern similarity between schizotypy and schizophrenia yields new insights into a dimensional neurobiological continuity across the extended psychosis phenotype.
  • Item
    Thumbnail Image
    S94. PREDICTION OF CANNABIS RELAPSE IN CLINICAL HIGH-RISK INDIVIDUALS AND RECENT ONSET PSYCHOSIS - PRELIMINARY RESULTS FROM THE PRONIA STUDY
    Penzel, N ; Sanfelici, R ; Betz, L ; Antonucci, L ; Falkai, P ; Upthegrove, R ; Bertolino, A ; Borgwardt, S ; Brambilla, P ; Lencer, R ; Meisenzahl, E ; Ruhrmann, S ; Salokangas, RKR ; Pantelis, C ; Schultze-Lutter, F ; Wood, S ; Koutsouleris, N ; Kambeitz, J (Oxford University Press (OUP), 2020-05-18)
  • Item
    Thumbnail Image
    S12. A MACHINE LEARNING FRAMEWORK FOR ROBUST AND RELIABLE PREDICTION OF SHORT- AND LONG-TERM CLINICAL RESPONSE IN INITIALLY ANTIPSYCHOTIC-NAïVE SCHIZOPHRENIA PATIENTS BASED ON MULTIMODAL NEUROPSYCHIATRIC DATA
    Ambrosen, KS ; Skjerbæk, MW ; Foldager, J ; Axelsen, MC ; Bak, N ; Arvastson, L ; Christensen, SR ; Johansen, LB ; Raghava, JM ; Oranje, B ; Rostrup, E ; Nielsen, MØ ; Osler, M ; Fagerlund, B ; Pantelis, C ; Kinon, BJ ; Glenthøj, BY ; Hansen, LK ; Ebdrup, BH (Oxford University Press (OUP), 2020-05-18)
  • Item
    Thumbnail Image
    T223. MULTIVARIATE PREDICTION OF FOLLOW UP SOCIAL AND OCCUPATIONAL OUTCOME IN CLINICAL HIGH-RISK INDIVIDUALS BASED ON GRAY MATTER VOLUMES AND HISTORY OF ENVIRONMENTAL ADVERSE EVENTS
    Antonucci, L ; Pigoni, A ; Sanfelici, R ; Kambeitz-Ilankovic, L ; Dwyer, D ; Ruef, A ; Chisholm, K ; Haidl, T ; Rosen, M ; Kambeitz, J ; Ruhrmann, S ; Schultze-Lutter, F ; Falkai, P ; Lencer, R ; Dannlowski, U ; Upthegrove, R ; Salokangas, R ; Pantelis, C ; Meisenzahl, E ; Wood, S ; Brambilla, P ; Borgwardt, S ; Bertolino, A ; Koutsouleris, N (Oxford University Press (OUP), 2020-05-18)
  • Item
    Thumbnail Image
    T162. THICKER PREFRONTAL CORTEX IS ASSOCIATED WITH SUBCLINICAL NEGATIVE SYMPTOMS IN SCHIZOTYPY - AN ENIGMA CONSORTIUM META-ANALYSIS
    Kirschner, M ; Hodzic-Santor, B ; Kircher, T ; Nenadic, I ; Fornito, A ; Green, M ; Quide, Y ; Pantelis, C ; Dannlowski, U ; DeRosse, P ; Chan, R ; Debbané, M ; Rössler, W ; Lebedeva, I ; Park, H ; Marsman, J-B ; Gilleen, J ; Fett, A-K ; van Erp, T ; Turner, J ; Thompson, P ; Aleman, A ; Modinos, G ; Kaiser, S (Oxford University Press (OUP), 2020-05-18)
  • Item
    Thumbnail Image
    T60. GENETIC INFLUENCES ON MEMORY FUNCTIONS AND RELATED BRAIN STRUCTURES AND ASSOCIATIONS WITH SCHIZOPHRENIA SPECTRUM DISORDERS: A NATION-WIDE TWIN STUDY
    Lemvigh, C ; Brouwer, R ; Baruel Johansen, L ; Hilker, R ; Pantelis, C ; Glenthoj, B ; Fagerlund, B (Oxford University Press (OUP), 2020-05-18)
  • Item
    Thumbnail Image
    T21. DEVELOPMENT OF PROTEOMIC PREDICTION MODELS FOR OUTCOMES IN THE CLINICAL HIGH RISK STATE AND PSYCHOTIC EXPERIENCES IN ADOLESCENCE: MACHINE LEARNING ANALYSES IN TWO NESTED CASE-CONTROL STUDIES
    Mongan, D ; Föcking, M ; Healy, C ; Raj Susai, S ; Cagney, G ; Cannon, M ; Zammit, S ; Nelson, B ; McGorry, P ; Nordentoft, M ; Krebs, M-O ; Riecher-Rössler, A ; Bressan, R ; Barrantes-Vidal, N ; Borgwardt, S ; Ruhrmann, S ; Sachs, G ; Van der Gaag, M ; Rutten, B ; Pantelis, C ; De Haan, L ; Valmaggia, L ; Kempton, M ; McGuire, P ; Cotter, D (Oxford University Press (OUP), 2020-05-18)
  • Item
    Thumbnail Image
    T18. EFFECTS OF COGNITIVE REMEDIATION ON WHITE MATTER IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS – A RANDOMIZED, CONTROLLED CLINICAL TRIAL
    Kristensen, T ; Ebdrup, BH ; Hjorthøj, C ; Mandl, RCW ; Mitta Raghava, J ; Møllegaard Jepsen, JR ; Fagerlund, B ; Glenthøj, LB ; Wenneberg, C ; Krakauer, K ; Pantelis, C ; Glenthøj, BY ; Nordentoft, M (Oxford University Press (OUP), 2020-05-18)
  • Item
    Thumbnail Image
    O6.6. MULTIMODAL PROGNOSIS OF NEGATIVE SYMPTOM SEVERITY IN INDIVIDUALS WITH INCREASED RISK OF DEVELOPING PSYCHOSIS
    Hauke, D ; Schmidt, A ; Studerus, E ; Andreou, C ; Riecher-Rössler, A ; Radua, J ; Kambeitz, J ; Ruef, A ; Dwyer, D ; Sanfelici, R ; Penzel, N ; Haas, S ; Antonucci, L ; Schultze-Lutter, F ; Ruhrmann, S ; Hietala, J ; Brambilla, P ; Koutsouleris, N ; Meisenzahl, E ; Pantelis, C ; Rosen, M ; Salokangas, RKR ; Upthegrove, R ; Wood, S ; Borgwardt, S (Oxford University Press (OUP), 2020-05-18)