Psychiatry - Research Publications

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    Attention-control training as an early intervention for veterans leaving the military: A pilot randomized controlled trial
    Metcalf, O ; O'Donnell, ML ; Forbes, D ; Bar-Haim, Y ; Hodson, S ; Bryant, RA ; McFarlane, AC ; Morton, D ; Poerio, L ; Naim, R ; Varker, T (WILEY, 2022-08)
    Transitioning out of the military can be a time of change and challenge. Research indicates that altered threat monitoring in military populations may contribute to the development of psychopathology in veterans, and interventions that adjust threat monitoring in personnel leaving the military may be beneficial. Australian Defence Force personnel (N = 59) transitioning from the military were randomized to receive four weekly sessions of either attention-control training or a placebo attention training. The primary outcome was symptoms of posttraumatic stress disorder (PTSD), as measured using the PTSD Checklist for DSM-5 (PCL-5) at posttreatment. Following training, participants who received attention-control training reported significantly lower levels of PTSD symptoms, Hedges' g = 0.86, 95% CI [0.37, 1.36], p = .004, and significantly improved work and social functioning, Hedges' g = 0.93, 95% CI [0.46, 1.39], p = .001, relative to those in the placebo condition. Moreover, no participants who received attention-control training worsened with regard to PTSD symptoms, whereas 23.8% of those who received the placebo attention training experienced an increase in PTSD symptoms. The preliminary findings from this pilot study add to a small body of evidence supporting attention-control training as a viable indicated early intervention approach for PTSD that is worthy of further research.
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    Ambulatory assessment to predict problem anger in trauma-affected adults: Study protocol
    Metcalf, O ; Finlayson-Short, L ; Lamb, KE ; Zaloumis, S ; O'Donnell, ML ; Qian, T ; Varker, T ; Cowlishaw, S ; Brotman, M ; Forbes, D ; Cowley, H (PUBLIC LIBRARY SCIENCE, 2022-12-22)
    BACKGROUND: Problem anger is common after experiencing a traumatic event. Current evidence-driven treatment options are limited, and problem anger negatively affects an individual's capacity to engage with traditional psychological treatments. Smartphone interventions hold significant potential in mental health because of their ability to deliver low-intensity, precision support for individuals at the time and place they need it most. While wearable technology has the capacity to augment smartphone-delivered interventions, there is a dearth of evidence relating to several key areas, including feasibility of compliance in mental health populations; validity of in vivo anger assessment; ability to predict future mood states; and delivery of timely and appropriate interventions. METHODS: This protocol describes a cohort study that leverages 10 days of ambulatory assessment in the form of ecological momentary assessment and a wearable. Approximately 100 adults with problem anger will complete four-hourly in vivo mobile application-delivered micro-surveys on anger intensity, frequency, and verbal and physical aggression, as well as other self-reported mental health and wellbeing measures. Concurrently, a commercial wearable device will continuously record indicators of physiological arousal. The aims are to test the feasibility and acceptability of ambulatory assessment in a trauma-affected population, and determine whether a continuously measured physiological indicator of stress predicts self-reported anger intensity. DISCUSSION: This study will contribute new data around the ability of physiological indicators to predict mood state in individuals with psychopathology. This will have important implications for the design of smartphone-delivered interventions for trauma-affected individuals, as well as for the digital mental health field more broadly.
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    Regional Research-Practice-Policy Partnerships in Response to Climate-Related Disparities: Promoting Health Equity in the Pacific
    Palinkas, LA ; O'Donnell, M ; Kemp, S ; Tiatia, J ; Duque, Y ; Spencer, M ; Basu, R ; Del Rosario, KI ; Diemer, K ; Doma, B ; Forbes, D ; Gibson, K ; Graff-Zivin, J ; Harris, BM ; Hawley, N ; Johnston, J ; Lauraya, F ; Maniquiz, NEF ; Marlowe, J ; McCord, GC ; Nicholls, I ; Rao, S ; Saunders, AK ; Sortino, S ; Springgate, B ; Takeuchi, D ; Ugsang, J ; Villaverde, V ; Wells, KB ; Wong, M (MDPI, 2022-08)
    Although climate change poses a threat to health and well-being globally, a regional approach to addressing climate-related health equity may be more suitable, appropriate, and appealing to under-resourced communities and countries. In support of this argument, this commentary describes an approach by a network of researchers, practitioners, and policymakers dedicated to promoting climate-related health equity in Small Island Developing States and low- and middle-income countries in the Pacific. We identify three primary sets of needs related to developing a regional capacity to address physical and mental health disparities through research, training, and assistance in policy and practice implementation: (1) limited healthcare facilities and qualified medical and mental health providers; (2) addressing the social impacts related to the cooccurrence of natural hazards, disease outbreaks, and complex emergencies; and (3) building the response capacity and resilience to climate-related extreme weather events and natural hazards.
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    Intimate Partner Violence (IPV) in Military and Veteran Populations: A Systematic Review of Population-Based Surveys and Population Screening Studies
    Cowlishaw, S ; Freijah, I ; Kartal, D ; Sbisa, A ; Mulligan, A ; Notarianni, M ; Couineau, A-L ; Forbes, D ; O'Donnell, M ; Phelps, A ; Iverson, KM ; Heber, A ; O'Dwyer, C ; Smith, P ; Hosseiny, F (MDPI, 2022-07)
    Intimate partner violence (IPV) may be a major concern in military and veteran populations, and the aims of this systematic review were to (1) provide best available estimates of overall prevalence based on studies that are most representative of relevant populations, and (2) contextualise these via examination of IPV types, impacts, and context. An electronic search of PsycINFO, CINHAL, PubMed, and the Cochrane Library databases identified studies utilising population-based designs or population screening strategies to estimate prevalence of IPV perpetration or victimisation reported by active duty (AD) military personnel or veterans. Random effects meta-analyses were used for quantitative analyses and were supplemented by narrative syntheses of heterogeneous data. Thirty-one studies involving 172,790 participants were included in meta-analyses. These indicated around 13% of all AD personnel and veterans reported any recent IPV perpetration, and around 21% reported any recent victimisation. There were higher rates of IPV perpetration in studies of veterans and health service settings, but no discernible differences were found according to gender, era of service, or country of origin. Psychological IPV was the most common form identified, while there were few studies of IPV impacts, or coercive and controlling behaviours. The findings demonstrate that IPV perpetration and victimisation occur commonly among AD personnel and veterans and highlight a strong need for responses across military and veteran-specific settings. However, there are gaps in understanding of impacts and context for IPV, including coercive and controlling behaviours, which are priority considerations for future research and policy.
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    Prevalence of gambling problems, help-seeking, and relationships with trauma in veterans
    Metcalf, O ; Lawrence-Wood, E ; Baur, J ; Van Hooff, M ; Forbes, D ; O'Donnell, M ; Sadler, N ; Hodson, S ; Benassi, H ; Varker, T ; Battersby, M ; McFarlane, AC ; Cowlishaw, S ; Osório, FL (PUBLIC LIBRARY SCIENCE, 2022-05-25)
    BACKGROUND AND AIMS: Veterans who have recently left the military (i.e., transitioned) may be vulnerable to the development of psychiatric disorders, but little is known about gambling problems in this population. This study investigated the prevalence and risk factors of gambling problems, help-seeking amongst veterans with gambling problems, and relationships with trauma and posttraumatic psychopathology. METHODS: Cross-sectional self-report survey data from 3,511 Australian Defence Force members who left the military within the past five years. Surveys included measures of gambling problems (PGSI); depressive symptoms (PHQ-9); posttraumatic stress disorder (PCL-5); help-seeking behaviours; military and non-military-related trauma. RESULTS: Prevalence rates for problem gambling (PGSI ≥ 5) were 4.6%, while an additional 8.8% were classified in terms of at-risk gambling (PGSI = 1-4). Time since leaving the military was not associated with gambling problems. Only 2.1% of veterans with problem gambling reported help-seeking for their gambling. While trauma exposure, depression, and Posttraumatic Stress Disorder (PTSD) were all related to gambling problems at the bivariate level, only arousal and dysphoric-related affect were uniquely associated with gambling problems when adjusting for covariates. DISCUSSION: Gambling problems may be under-recognised relative to other psychiatric issues. Posttraumatic mental health problems, rather than trauma exposure per se, may explain the relationship between trauma and gambling problems. CONCLUSIONS: Some veterans are in a period of vulnerability during transition out of military service, and harms associated with gambling problems may be exacerbated during this period.
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    Pathways to mental health care in active military populations across the Five-Eyes nations: An integrated perspective
    Fikretoglu, D ; Sharp, M-L ; Adler, AB ; Belanger, S ; Benassi, H ; Bennett, C ; Bryant, R ; Busuttil, W ; Cramm, H ; Fear, N ; Greenberg, N ; Heber, A ; Hosseiny, F ; Hoge, CW ; Jetly, R ; McFarlane, A ; Morganstein, J ; Murphy, D ; O'Donnell, M ; Phelps, A ; Richardson, DJ ; Sadler, N ; Schnurr, PP ; Smith, P ; Ursano, R ; Van Hooff, M ; Wessely, S ; Forbes, D ; Pedlar, D (PERGAMON-ELSEVIER SCIENCE LTD, 2022-02)
    Military service is associated with increased risk of mental health problems. Previous reviews have pointed to under-utilization of mental health services in military populations. Building on the most recent systematic review, our narrative, critical review takes a complementary approach and considers research across the Five-Eyes nations from the past six years to update and broaden the discussion on pathways to mental healthcare in military populations. We find that at a broad population level, there is improvement in several indicators of mental health care access, with greater gains in initial engagement, time to first treatment contact, and subjective satisfaction with care, and smaller gains in objective indicators of adequacy of care. Among individual-level barriers to care-seeking, there is progress in improving recognition of need for care and reducing stigma concerns. Among organizational-level barriers, there are advances in availability of services and cultural acceptance of care-seeking. Other barriers, such as concerns around confidentiality, career impact, and deployability persist, however, and may account for some remaining unmet need. To address these barriers, new initiatives that are more evidence-based, theoretically-driven, and culturally-sensitive, are therefore needed, and must be rigorously evaluated to ensure they bring about additional improvements in pathways to care.
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    Dropout from guideline-recommended psychological treatments for posttraumatic stress disorder: A systematic review and meta-analysis
    Varker, T ; Jones, KA ; Arjmand, HA ; Hinton, M ; Hiles, SA ; Freijah, I ; Forbes, D ; Kartal, D ; Phelps, A ; Bryant, RA ; McFarlane, A ; Hopwood, M ; O'Donnell, M (Elsevier BV, 2021-04-01)
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    Health Service Interventions for Intimate Partner Violence among Military Personnel and Veterans: A Framework and Scoping Review
    Cowlishaw, S ; Sbisa, A ; Freijah, I ; Kartal, D ; Mulligan, A ; Notarianni, M ; Iverson, K ; Couineau, A-L ; Forbes, D ; O'Donnell, M ; Phelps, A ; Smith, P ; Hosseiny, F (MDPI, 2022-03)
    IPV is a significant concern among active duty (AD) military personnel or veterans, and there is a need for initiatives to address violence perpetrated by such personnel, and IPV victimisation in military and veteran-specific contexts. The aim of this paper was to provide an overview of major IPV intervention approaches and evidence in military and veteran-specific health services. A scoping review was conducted involving a systematic search of all available published studies describing IPV interventions in military and veteran-specific health services. Findings were synthesised narratively, and in relation to a conceptual framework that distinguishes across prevention, response, and recovery-oriented strategies. The search identified 19 studies, all from the U.S., and only three comprised randomised trials. Initiatives addressed both IPV perpetration and victimisation, with varied interventions targeting the latter, including training programs, case identification and risk assessment strategies, and psychosocial interventions. Most initiatives were classified as responses to IPV, with one example of indicated prevention. The findings highlight an important role for specific health services in addressing IPV among AD personnel and veterans, and signal intervention components that should be considered. The limited amount of empirical evidence indicates that benefits of interventions remain unclear, and highlights the need for targeted research.
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    Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information
    Maihofer, AX ; Choi, KW ; Coleman, JR ; Daskalakis, NP ; Denckla, CA ; Ketema, E ; Morey, RA ; Polimanti, R ; Ratanatharathorn, A ; Torres, K ; Wingo, AP ; Zai, CC ; Aiello, AE ; Almli, LM ; Amstadter, AB ; Andersen, SB ; Andreassen, OA ; Arbisi, PA ; Ashley-Koch, AE ; Austin, SB ; Avdibegovic, E ; Borglum, AD ; Babic, D ; Baekvad-Hansen, M ; Baker, DG ; Beckham, JC ; Bierut, LJ ; Bisson, J ; Boks, MP ; Bolger, EA ; Bradley, B ; Brashear, M ; Breen, G ; Bryant, RA ; Bustamante, AC ; Bybjerg-Grauholm, J ; Calabrese, JR ; Caldas-de-Almeida, JM ; Chen, C-Y ; Dale, AM ; Dalvie, S ; Deckert, J ; Delahanty, DL ; Dennis, MF ; Disner, SG ; Domschke, K ; Duncan, LE ; Kulenovic, AD ; Erbes, CR ; Evans, A ; Farrer, LA ; Feeny, NC ; Flory, JD ; Forbes, D ; Franz, CE ; Galea, S ; Garrett, ME ; Gautam, A ; Gelaye, B ; Gelernter, J ; Geuze, E ; Gillespie, CF ; Goci, A ; Gordon, SD ; Guffanti, G ; Hammamieh, R ; Hauser, MA ; Heath, AC ; Hemmings, SMJ ; Hougaard, DM ; Jakovljevic, M ; Jett, M ; Johnson, EO ; Jones, I ; Jovanovic, T ; Qin, X-J ; Karstoft, K-I ; Kaufman, ML ; Kessler, RC ; Khan, A ; Kimbrel, NA ; King, AP ; Koen, N ; Kranzler, HR ; Kremen, WS ; Lawford, BR ; Lebois, LAM ; Lewis, C ; Liberzon, I ; Linnstaedt, SD ; Logue, MW ; Lori, A ; Lugonja, B ; Luykx, JJ ; Lyons, MJ ; Maples-Keller, JL ; Marmar, C ; Martin, NG ; Maurer, D ; Mavissakalian, MR ; McFarlane, A ; McGlinchey, RE ; McLaughlin, KA ; McLean, SA ; Mehta, D ; Mellor, R ; Michopoulos, V ; Milberg, W ; Miller, MW ; Morris, CP ; Mors, O ; Mortensen, PB ; Nelson, EC ; Nordentoft, M ; Norman, SB ; O'Donnell, M ; Orcutt, HK ; Panizzon, MS ; Peters, ES ; Peterson, AL ; Peverill, M ; Pietrzak, RH ; Polusny, MA ; Rice, JP ; Risbrough, VB ; Roberts, AL ; Rothbaum, AO ; Rothbaum, BO ; Roy-Byrne, P ; Ruggiero, KJ ; Rung, A ; Rutten, BPF ; Saccone, NL ; Sanchez, SE ; Schijven, D ; Seedat, S ; Seligowski, A ; Seng, JS ; Sheerin, CM ; Silove, D ; Smith, AK ; Smoller, JW ; Sponheim, SR ; Stein, DJ ; Stevens, JS ; Teicher, MH ; Thompson, WK ; Trapido, E ; Uddin, M ; Ursano, RJ ; van den Heuvel, LL ; Van Hooff, M ; Vermetten, E ; Vinkers, CH ; Voisey, J ; Wang, Y ; Wang, Z ; Werge, T ; Williams, MA ; Williamson, DE ; Winternitz, S ; Wolf, C ; Wolf, EJ ; Yehuda, R ; Young, KA ; Young, RM ; Zhao, H ; Zoellner, LA ; Haas, M ; Lasseter, H ; Provost, AC ; Salem, RM ; Sebat, J ; Shaffer, RA ; Wu, T ; Ripke, S ; Daly, MJ ; Ressler, KJ ; Koenen, KC ; Stein, MB ; Nievergelt, CM (ELSEVIER SCIENCE INC, 2022-04-01)
    BACKGROUND: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). METHODS: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran Program GWAS of PTSD total symptoms. RESULTS: GWASs of PTSD symptoms and LTE burden identified 5 and 6 independent genome-wide significant loci, respectively. There was a 72% genetic correlation between PTSD and LTE. PTSD and LTE showed largely similar patterns of genetic correlation with other traits, albeit with some distinctions. Adjusting PTSD for LTE reduced PTSD heritability by 31%. Multivariate analysis of PTSD and LTE increased the effective sample size of the PTSD GWAS by 20% and identified 4 additional loci. Four of these 9 PTSD loci were independently replicated in the Million Veteran Program. CONCLUSIONS: Through using a quantitative trait measure of PTSD, we identified novel risk loci not previously identified using prior case-control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power through multivariate methods.
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    Mental health across the early years in the military
    Dell, L ; Casetta, C ; Benassi, H ; Cowlishaw, S ; Agathos, J ; O'Donnell, M ; Crane, M ; Lewis, V ; Pacella, B ; Terhaag, S ; Morton, D ; McFarlane, A ; Bryant, R ; Forbes, D (CAMBRIDGE UNIV PRESS, 2023-06)
    BACKGROUND: The mental health impact of the initial years of military service is an under-researched area. This study is the first to explore mental health trajectories and associated predictors in military members across the first 3-4 years of their career to provide evidence to inform early interventions. METHODS: This prospective cohort study surveyed Australian Defence personnel (n = 5329) at four time-points across their early military career. Core outcomes were psychological distress (K10+) and posttraumatic stress symptoms [four-item PTSD Checklist (PCL-4)] with intra-individual, organizational and event-related trajectory predictors. Latent class growth analyses (LCGAs) identified subgroups within the sample that followed similar longitudinal trajectories for these outcomes, while conditional LCGAs examined the variables that influenced patterns of mental health. RESULTS: Three clear trajectories emerged for psychological distress: resilient (84.0%), worsening (9.6%) and recovery (6.5%). Four trajectories emerged for post-traumatic stress, including resilient (82.5%), recovery (9.6%), worsening (5.8%) and chronic subthreshold (2.3%) trajectories. Across both outcomes, prior trauma exposure alongside modifiable factors, such as maladaptive coping styles, and increased anger and sleep difficulties were associated with the worsening and chronic subthreshold trajectories, whilst members in the resilient trajectories were more likely to be male, report increased social support from family/friends and Australian Defence Force (ADF) sources, and use adaptive coping styles. CONCLUSIONS: The emergence of symptoms of mental health problems occurs early in the military lifecycle for a significant proportion of individuals. Modifiable factors associated with wellbeing identified in this study are ideal targets for intervention, and should be embedded and consolidated throughout the military career.