- Anatomy and Neuroscience - Research Publications
Anatomy and Neuroscience - Research Publications
Permanent URI for this collection
3 results
Filters
Reset filtersSettings
Statistics
Citations
Search Results
Now showing
1 - 3 of 3
-
ItemLow rates of eligibility for lung cancer screening in patients undergoing computed tomography coronary angiographyLyne, C ; Zaw, S ; King, B ; See, K ; Manners, D ; Al-Kaisey, A ; Joshi, S ; Farouque, O ; Irving, L ; Johnson, D ; Steinfort, D (WILEY, 2018-10)Incidental findings, including pulmonary nodules, on computed tomography coronary angiography (CTCA) are common. Previous authors have suggested CTCA could allow opportunistic screening for lung cancer, though the lung cancer risk profile of this patient group has not previously been established. Smoking histories of 229 patients undergoing CTCA at two tertiary hospitals were reviewed and only 25% were current or former smokers aged 55-80 years old. Less than half of this group were eligible for screening based on the PLCOm2012 risk model. We conclude that routine screening in the form of full thoracic field imaging, of individuals undergoing CTCA is not appropriate as it would likely result in net harm.
-
ItemOutcomes following resection of non-small cell lung cancer in octogenariansVazirani, J ; Moraes, J ; Barnett, S ; Johnson, DF ; Knight, S ; Miller, A ; Wright, G ; Alam, NZ ; Conron, M ; Irving, LB ; Antippa, P ; Steinfort, DP (WILEY, 2018-12)BACKGROUND: The treatment of choice for early stage non-small cell lung cancer (NSCLC) is surgical resection. Little is known about the short- and long-term outcomes among very elderly patients. We sought to determine predictors of short- and long-term survival among octogenarians undergoing curative-intent resection for NSCLC in Victoria, Australia. METHODS: We retrospectively reviewed data from all patients aged ≥80 years who underwent curative-intent resection for NSCLC over 12 years (January 2005-December 2016) across five tertiary centres. We examined effect of age, stage of disease, extent of surgery and lung function on short- and long-term survival. RESULTS: Two hundred patients aged ≥80 years underwent curative-intent resections. Mortality at 30 and 120 days was 2.9% and 5.9%, respectively. Increased early mortality was observed among those ≥83 years, at 30 days (6.8% versus 0.8%, P = 0.044) and 120 days (12.2% versus 2.3%, P = 0.0096). Early mortality was highest among patients ≥83 years requiring lobectomy, compared to sub-lobar resection at 120 days (17% versus 3.8%, P = 0.019). Long-term survival was predicted by age and stage of disease. Among patients with Stage I disease aged <83 years, lobectomy was associated with superior 5-year survival, compared to sub-lobar resection (83% versus 61%, P = 0.02). CONCLUSION: In carefully selected elderly patients undergoing curative-intent resection of early stage NSCLC, both short- and long-term outcomes appear consistent with younger historical cohorts. Early mortality was associated with lobectomy in those with advanced age. Older patients undergoing lobectomy appeared to be at highest risk for early mortality, while younger patients with Stage I disease undergoing at least lobectomy appear to have the best long-term survival.
-
ItemStarting beta-blockers during exacerbations of chronic obstructive pulmonary disease Author replyNeef, PA ; Burrell, LM ; McDonald, CF ; Irving, LB ; Johnson, DF ; Steinfort, DP (WILEY, 2018-02)