Anatomy and Neuroscience - Research Publications

Permanent URI for this collection

http://hdl.handle.net/11343/181

Filters

2012 1
1
Reset filters

Settings
Statistics
Citations
Author: Furness, John × Subject: Autonomic Nervous System; Nervous System and Disorders × Start date: 2012 ×

Search Results

Now showing 1 - 1 of 1
  • Item
    Thumbnail Image
    The roles of purinergic signaling during gastrointestinal inflammation
    Roberts, JA ; Lukewich, MK ; Sharkey, KA ; Furness, JB ; Mawe, GM ; Lomax, AE (ELSEVIER SCI LTD, 2012-12-01)
    Extracellular purines play important roles as neurotransmitters and paracrine mediators in the gastrointestinal (GI) tract. Inflammation of the GI tract causes marked changes in the release and extracellular catabolism of purines, and can modulate purinoceptor expression and/or signaling. The functional consequences of this include suppression of the purinergic component of inhibitory neuromuscular and neurovascular transmission, increased release of purines from immune and epithelial cells, loss of enteric neurons to damage through P2X(7) purinoceptors, and enhanced activation of pain fibres. The purinergic system represents an important target for drug therapies that may improve GI inflammation and its consequences.