Anatomy and Neuroscience - Research Publications

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Author: O'Brien, Terence × Author: Monif, Mastura × Start date: 2018 × End date: 2019 ×

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    Prognosis in autoimmune encephalitis: Database
    Broadley, J ; Seneviratne, U ; Beech, P ; Buzzard, K ; Butzkueven, H ; O'Brien, T ; Monif, M (ELSEVIER SCIENCE BV, 2018-12)
    Autoimmune encephalitis is a rare and debilitating disease. An important question in clinical neurology is what factors may be correlated with outcomes in autoimmune encephalitis. There is observational data describing statistical analyses on such variables, but there are no review articles that collaborate and interpret this information. This data in brief article represents the data collection for such a review (Broadley et al., 2018). Herein we summarize clinical information from 44 research articles, in particular pertaining to outcomes and prognostic variables.
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    Innate Immunity in the Central Nervous System: A Missing Piece of the Autoimmune Encephalitis Puzzle?
    Wesselingh, R ; Butzkueven, H ; Buzzard, K ; Tarlinton, D ; O'Brien, TJ ; Monif, M (FRONTIERS MEDIA SA, 2019-09-10)
    The autoimmune encephalitides are a group of autoimmune conditions targeting the central nervous system and causing severe clinical symptoms including drug-resistant seizures, cognitive dysfunction and psychiatric disturbance. Although these disorders appear to be antibody mediated, the role of innate immune responses needs further clarification. Infiltrating monocytes and microglial proliferation at the site of pathology could contribute to the pathogenesis of the disease with resultant blood brain barrier dysfunction, and subsequent activation of adaptive immune response. Both innate and adaptive immune cells can produce pro-inflammatory molecules which can perpetuate ongoing neuroinflammation and drive ongoing seizure activity. Ultimately neurodegenerative changes can ensue with resultant long-term neurological sequelae that can impact on ongoing patient morbidity and quality of life, providing a potential target for future translational research.