Now showing 1 - 3 of 3
ItemNo Preview AvailableThe Electric Field System of a Macular Ion Channel PlaqueHales, C ; Grayden, D ; Quiney, H (IEEE, 2011-01-01)Recent empirical neuroscience evidence increasingly supports an active role for the endogenous electromagnetic (EM) field system of brain tissue. These results undermine the long-held view that the field system is a causally inert byproduct of action potential and synapse electrochemical activity. The dominant originating mechanism for the endogenous EM field remains undetermined. The new observations make the isolation of an unambiguous original EM field source a matter of some urgency. As part of the process of elaboration of the field systems produced by coherent transmembrane filamentary currents (the most plausible original mechanism), this paper looks at the contribution by a localized density of cooperating ion channels in the form of the macular synaptic plaque engaged in conducting a post-synaptic current. The method uses the volume conduction formalism driven by filamentary currents that stand in for ion channels. Not surprisingly, the result is a pulsing dipole. Despite its extreme material abstraction, the result forms one of the basic mechanisms for future models capable of revealing whole-neuron and network-level endogenous EM field system.
ItemAcoustic analysis of the effects of 24 hours of sustained wakefulnessVogel, AP ; Fletcher, J ; Maruff, P (Australasian Speech Science and Technology Association, 2010)The effect of 24 hours of sustained wakefulness on the speech of healthy adults is poorly documented. Therefore, speech samples were systematically acquired (e.g., every four hours) from 18 healthy adults over 24 hours. Stimuli included automated and extemporaneous tasks, sustained vowel and a read passage. Measures of timing and frequency were derived acoustically using Praat and significant changes were observed on all tasks. The effect of fatigue on speech was found to be strongest just before dawn (after 22 hours). Key features of timing (e.g., mean pause length), frequency (e.g., F4 variation) and power (alpha ratio) changed as a function of increasing levels of fatigue. Index Terms: fatigue, voice, tiredness, clinical marker
ItemPrecision Medicine: Dawn of Supercomputing in ‘omics ResearchReumann, M ; Holt, KE ; Inouye, M ; Stinear, T ; Goudey, B ; Abraham, G ; WANG, Q ; Shi, F ; Kowalczyk, A ; Pearce, A ; Isaac, A ; Pope, BJ ; Butzkueven, H ; Wagner, J ; Moore, S ; Downton, M ; Church, PC ; Turner, SJ ; Field, J ; Southey, M ; Bowtell, D ; Schmidt, D ; Makalic, E ; Zobel, J ; Hopper, J ; Petrovski, S ; O'Brien, T (eResearch Australasia, 2011)