Medicine (Western Health) - Theses

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Author: Al Saedi, Ahmed Mohan × End date: 2017 ×

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    Role of circulating osteoprogenitors (COP) in musculoskeletal biology and function
    Al Saedi, Ahmed Mohan ( 2017)
    Circulating osteoprogenitor (COP) cells have gained increasing prominence in musculoskeletal research. This thesis explores the role of COP cells in age-related diseases such as osteoporosis, sarcopenia and frailty. In the process, we developed a new flow cytometric methodology to quantify COP cells and lamin A, an important component of COP cells which showed a strong association with frailty and ageing. This diagnostic method offers a valid and potential tool to diagnose osteosarcopenia and predict frailty and disability in older adults.