Physiotherapy - Theses
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ItemPelvic floor disorders in women with breast cancer( 2022)Problems related to bladder, bowel, sexual and pelvic floor (PF) muscle function are collectively termed PF disorders. Previous literature suggests that women with breast cancer may experience PF disorders at higher rates following cancer treatment than prior to cancer treatment. A causal pathway for this observation has not been clearly established. Pelvic floor muscle training (PFMT), the first-line management for treating PF disorders such as urinary incontinence (UI) and pelvic organ prolapse (POP), currently does not appear in breast cancer clinical care pathways. More data about PF disorders in women with breast cancer are required before PFMT can be included in clinical care pathways. Therefore, the aim of this thesis was to investigate PF disorders in women with breast cancer. While the abrupt precipitation of female sexual dysfunction (FSD) after breast cancer treatments is well documented, much less is known about bladder and bowel symptoms in this population. Study one, a systematic review and meta-analysis, assessed the prevalence and impact of bladder and bowel disorders in women with breast cancer. Results showed that 33% of women with breast cancer reported experiencing bladder disorders and 18% reported bowel disorders. The impact of bladder and bowel disorders in studies that used cancer-specific questionnaires was rated as low. Further studies using validated PF-specific questionnaires are required to assess the prevalence and impact of PF symptoms in this population. To address the research gap identified in the previous study, study two, a cross-sectional study, was conducted to compare the prevalence, distress and impact of PF disorders between women with and without breast cancer. Women in this study with breast cancer had a higher prevalence (although not significant) of UI, and significantly higher distress and impact of UI compared to women without breast cancer. These findings highlight that more studies are needed to understand which subgroups of women with breast cancer (e.g., women who have undergone a specific type of cancer treatment such as chemotherapy) may be most at risk of developing these symptoms. Study three, a secondary analysis of data collected as part of the previous cross-sectional study (study 2), was conducted to determine the prevalence of PF disorders according to breast cancer characteristics such as breast cancer stage and treatment type. Women in this study who underwent chemotherapy experienced the highest rates of UI (79%) and FI (24%) although this association was not statistically significant. The impact of PF disorders also appeared to increase with more time after breast cancer diagnosis. This demonstrates that the screening and treatment of PF disorders may be indicated as women enter the survivorship phase of their cancer recovery. Sexual dysfunction is another symptom that has been reported to have long-term negative impacts in women with breast cancer. Sexual function in women with breast cancer who experience UI has not been investigated. Study four, a matched control study using data collected as part of study two, compared the prevalence and severity of sexual dysfunction in matched women with and without breast cancer who experienced UI. Women who participated in this study with breast cancer and experience of UI reported significantly higher rates and severity of sexual dysfunction than women with UI of the same age, body mass index and parity without breast cancer. This finding adds to the existing body of literature that highlights the burden of FSD in women with breast cancer, and implies that clinicians may wish to consider the impact of UI when addressing FSD in this population. Study five, a cross-sectional study, compared the PF muscle function in women with and without breast cancer. The group of women in this study with breast cancer had reduced PF muscle strength and poorer relaxation ability compared to women without breast cancer. This suggests that PF therapies such as PF muscle training or relaxation techniques may be a therapeutic target to improve PF muscle function in women with breast cancer. Additionally, there is a need to better understand whether women with breast cancer who experience PF disorders are interested in seeking treatment for these symptoms during, or after breast cancer treatment. Study six, a qualitative study, explored the experiences of women with breast cancer who had PF disorders, and their perceived enablers and barriers to the uptake of treatment for PF disorders during their breast cancer recovery. Women in this study were divided as to whether they felt resigned to, or bothered by PF disorders. Their reactions to the experiences of PF disorders acted as a barrier or enabler to accessing treatment for PF disorders. For those who are interested in treatment for their symptoms, further research is required to investigate whether PF muscle therapies are a feasible treatment option for women with breast cancer. No trials to date have tested the feasibility of implementing a PFMT program in women with breast cancer. Study seven, a pilot clinical trial, assessed the feasibility of recruiting into a PFMT delivered via telehealth to treat UI in women with breast cancer. Women underwent a 12-week individualised PFMT program using a home-based intra-vaginal pressure biofeedback device (femfit). The consent rate was 100%. A significant decline in the prevalence, frequency and severity of UI was observed in this feasibility study following treatment. Pelvic floor muscle strength increased significantly from pre- to post-intervention, a mean difference of 4.8 mmHg (95%CI 3.9, 5.5). This indicated that PFMT delivered via telehealth may potentially be beneficial in treating UI, particularly stress UI in women with breast cancer. In conclusion, the findings of this thesis highlight that women with breast cancer may experience PF disorders, particularly UI, at a higher magnitude than women without breast cancer. Women with breast cancer who are bothered by their PF symptoms are interested in receiving information and treatment for PF disorders. This indicates that there may be a role of PF physiotherapy in addressing PF disorders in this population. While further research is required, these findings present an opportunity to place PF physiotherapy in breast cancer care pathways to ultimately improve the quality of life in women with breast cancer.
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ItemSystematic investigation of early-phase trial designs for upper limb therapy post-stroke( 2022)A lack of early-phase trials to systematically investigate dose and target population during intervention development is a likely reason for non-pharmacological stroke recovery trials falling short of the outcomes expected by researchers and clinicians and needed by people living with stroke. The overall objective of the work presented in this thesis was to systematically investigate dose, target population and decision-logic of early-phase trial designs in non-pharmacological stroke recovery. To achieve the objective, Study 1 developed the tools required to appraise early-phase trials of preclinical and clinical non-pharmacological stroke recovery motor interventions and embedded them in an accompanying protocol for a systematic scoping review. Study 2 executed the systematic scoping review and demonstrated a lack of published and high-quality preclinical and clinical early-phase stroke recovery motor trials that explicitly aimed to investigate dose. Study 3 established a lack of Phase I stroke trials that were registered or funded. Collectively, these studies resulted in original contributions in the form of (a) a systematic discovery pipeline tool, (b) an Early Phase Research Quality Checklist, and (c) an understanding that systematic early-phase research is rarely completed. The above findings provided an essential basis for in-depth investigation of the adaption of early-phase trial designs for application to the domain of clinical non-pharmacological stroke recovery motor interventions. As a part of this investigation, Study 3 developed a decision support tool to guide the design of Phase I non-pharmacological trials that can escalate more than one dose dimension. Study 4 utilised the decision support tool to guide the design and implementation of a multidimensional Phase I dose-ranging trial of an upper limb motor intervention delivered early post-stroke. This trial is ongoing, with the current tolerable dose being three 15-minute upper limb sessions per day. Finally, Study 5 investigated the impact of target population selection on the generalisability of upper limb motor trials conducted early post-stroke. Participant sampling was found to be a complex process that needs to be adequately reported and systematically undertaken to ensure an appropriate balance between internal and external validity. Overall, these studies have resulted in the original contributions in the form of: (d) a Phase I decision support tool, (e) confirmation that a multidimensional Phase I dose-ranging trial is feasible to implement, (f) confirmation that the current tolerable dose range is higher than usual care upper limb therapy provided early post-stroke in Australia, (g) an understanding that a lack of reporting in trials is impacting generalisability, and (h) an understanding that broadening eligibility criteria alone is unlikely to improve generalisability. Collectively, these contributions have enriched early-phase stroke recovery research by identifying barriers to its completion and providing solutions to support its uptake and quality. The completed research provides a sound basis for ongoing work to demonstrate the benefits of embedding intervention development through a systematic discovery pipeline approach within the confines of intervention complexity and the heterogeneous context of stroke. Adopting a systematic approach to intervention development via early-phase trials is achievable and likely a crucial step in bringing the field closer to identifying practice-changing interventions.
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ItemDetermining discharge destination in acute general medicine( 2022)The field of general medicine (also known as internal medicine) utilises a patient-centred, multidisciplinary approach to manage acutely unwell, complex patients. This heterogeneous medical discipline is known for its increased hospital admissions (500,000 admissions per year in Australia), longer length of hospital stays (1.83 million days per year in Australia), and high 28-day readmission rates (up to 21% globally). Notably, up to a third of general medical bed days consist of patients who are “medically ready for discharge”, but remain in hospital for non-medical reasons, such as waiting for post-acute facilities, clinician indecision and co-ordination of services. Thus, early, and accurate identification of such patient needs may allow for timelier discharge. The primary aim of this thesis was to identify predictors of discharge destination from acute general medical units and the secondary aim was to explore physical activity in the context of a general medicine hospital admission. In the first section of this thesis (Determining Discharge Destination), two systematic reviews were undertaken. The first systematic review identified 23 assessment tools and 44 patient factors associated with discharge destination in acute general medicine. The second systematic review evaluated the psychometric properties of these assessment tools and identified that the de Morton Mobility Index (DEMMI), Alpha Functional Independence Measure (AlphaFIM), the Barthel Index and the Mini Mental State Examination (MMSE) had the strongest psychometric properties. This section of the thesis identified a paucity in recent literature in an Australian context. Thus, the third study in this section of the thesis was a prospective observational study involving 417 acute general medical patients from a large tertiary hospital in Australia. This study found 54 factors associated with discharge destination and created two models to predict patients who were discharged home or “not home”. The models included the “DEMMI and toilet transfers” and the “AlphaFIM and walking independence”. The second section of this thesis (Physical Activity in General Medicine) consists of a prospective observational study involving 50 acute general medical inpatients. Physical activity was found to be low prior to and during an acute general medical admission. The tool used to measure pre-hospitalisation physical activity demonstrated a floor effect and indicates the need for a valid and reliable assessment tool that is appropriate for frail older people. No relationship was found between pre-hospital and in-hospital physical activity levels. A fair and significant association was found between both pre-hospital and in-hospital physical activity and mobility performance meaning that patients who had better mobility scores on admission had higher physical activity levels prior to and during their hospital admission. The findings of this thesis provide a comprehensive examination of tools to assist early identification of discharge destination, supplemented by an exploration of physical activity prior to and during an acute general medical hospital admission. This may facilitate a timelier discharge which has potential to improve both patient and hospital outcomes. Areas for translation of known research into clinical practice include a development of a core acute assessment tool set and promotion of physical activity. This thesis also highlights future directions for research, especially regarding further analysis of psychometric properties of known assessment tools associated with discharge (including validation of the two created models), and the creation of a valid and reliable assessment tool for physical activity in frail older people.
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ItemEvaluating the effect of self-management interventions on medial tibiofemoral contact force using electromyogram-informed neuromusculoskeletal modelling in people at risk of, and with, established knee osteoarthritis( 2022)Knee osteoarthritis (OA) predominantly involving the medial tibiofemoral compartment is a major public health problem worldwide causing pain, disability, and reduced quality of life. Longitudinal data suggest that higher knee loads during walking are associated with structural disease progression in people with medial knee OA. Higher knee loads during walking are also associated with structural disease onset in high-risk groups such as people who have undergone arthroscopic partial meniscectomy (APM). As there is no cure for OA, conservative interventions such as strengthening exercise and “appropriate” footwear are recommended throughout the OA disease continuum. However, no studies have been able to demonstrate that exercise can reduce knee loads in those at risk of, and with, established knee OA and belief that exercise could generate harmful knee loads continues to exist among patients and clinicians. This ambiguity also extends to footwear interventions, where stable supportive shoe types are recommended in most clinical guidelines despite conflicting biomechanical evidence that suggests flat flexible shoe types may reduce knee loads. A critical limitation of the current body of evidence is the use of the external knee adduction moment (KAM) as a surrogate measure of internal medial tibiofemoral contact force (MTCF). Change in the MTCF does not necessarily correspond directly with change in the KAM, predominantly due to the role internal muscle forces play in stabilizing the knee against these external loads. The use of electromyogram (EMG)-informed neuromusculoskeletal modelling is a promising means to consider the influence of muscle in estimates of internal contact force. However, it has not yet been implemented to estimate loads in knee OA intervention studies. The overarching aim of this thesis is to implement EMG-informed neuromusculoskeletal modelling to estimate MTCF during exercise and footwear interventions in people following APM (high-risk for developing knee OA), and those with established medial knee OA. This thesis first describes secondary analyses from two randomised controlled trials. In Study 1 (Chapter 4), which involved 41 participants aged between 30-50 years with medial APM in the prior 3-12 months, no significant difference in MTCF (peak and impulse) was found following a 12-week functional weightbearing exercise program compared to no intervention. In Study 2 (Chapter 5), which involved 62 participants aged over 50 with medial knee OA and varus malalignment, no significant difference in MTCF (peak or impulse) was found between a 12-week functional weightbearing (WB) and a 12-week non-weightbearing (NWB) quadriceps strengthening exercise program. Interestingly, the functional WB exercise program reduced the external contribution to MTCF, while the NWB quadriceps strengthening program reduced the muscle contribution to MTCF. This thesis then describes two cross-sectional studies, both utilising the same cohort of 28 people over the age of 50 with medial knee OA and varus malalignment. The first (Study 3, Chapter 6) compared the immediate effect of stable supportive and flat flexible shoes on continuous and discrete measures of MTCF during walking. Statistical parametric mapping (SPM) showed lower MTCF in the stable supportive compared to flat flexible shoes during 5-18% of stance phase. For the discrete outcomes, loading impulse, mean loading rate, and max loading rate were lower in stable supportive shoes compared to flat flexible shoes. The second cross-sectional study (Study 4, Chapter 7) evaluated the MTCF and muscle forces during each of three weightbearing exercises (double leg squat, forward lunge, and single-leg heel raise), relative to walking. Results showed that knee extensor and flexor force was higher during squatting and lunging compared to walking, while the MTCF was lower during squatting and heel raises compared to walking. Collectively, this thesis does not provide any evidence that 12-week functional weightbearing exercise programs can change MTCF in people following APM and with medial knee OA and varus malalignment. However, novel findings suggest that stable supportive shoes can reduce aspects of the MTCF compared to flat flexible shoes, suggesting that this shoe type may be most suitable for people with knee OA and varus malalignment. This thesis also provides evidence that common weightbearing exercises (squatting, lunging and heel raises) do not result in harmful increases in MTCF. These exercises may therefore be used safely in clinical settings for people with knee OA and varus malalignment.
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ItemExploring opportunities to improve the health literacy responsiveness of hospital outpatient waiting areas( 2022)Creating health services which are responsive to the health literacy needs of consumers has potential to improve health outcomes and reduce healthcare costs. ‘Responsive’ health services provide appropriate and accessible health information, resources, supports and care environments for consumers. Providing health information, resources and supports in waiting areas is common practice; however, there is limited evidence as to whether this practice is meeting the health literacy needs of adult consumers in hospital outpatient settings. The purpose of this thesis was to explore consumer perspectives on the health literacy responsiveness of hospital outpatient rehabilitation waiting areas. A scoping review of the literature explored what was known from published and grey literature about the use of outpatient waiting areas to contribute to health literacy. The review found limited studies in hospital outpatient waiting areas. Studies in primary care and community waiting areas suggested that targeted interventions may improve health literacy and related outcomes such as behaviours, and clinical outcomes. An observational study in two hospital outpatient waiting areas investigated the number and types of health information, resources and supports available for consumers as well as how often and for how long consumers accessed these whilst waiting for their appointments. In-person and video recorded observations revealed that a range of items were available for consumers in the waiting area, however, these were rarely used. A constructivist grounded theory study explored and theorised opportunities for hospital outpatient waiting areas to contribute to health literacy. Participant observation and semi-structured interviews were conducted with 33 adult consumers attending outpatient rehabilitation at two hospitals. The substantive theory of ‘seeking choice to fulfill health literacy needs’ and related categories indicated that consumers sought choice reflective of their needs; however, the waiting area offered limited choice. Consumers shared ideas to address the lack of choice. A cross-cultural qualitative in-depth case study explored the perceptions and experiences of CALD consumers accessing health information and resources in hospitals including in an outpatient waiting area. Four adult consumers (two patients, two caregivers) from CALD backgrounds participated in semi-structured interviews with bilingual researchers. Data were analysed using reflexive thematic analysis. Five themes indicated that available health information is not responsive to the language, literacy, or cultural needs of CALD consumers. A secondary analysis of qualitative interview data using the Framework Method investigated the barriers and enablers experienced by consumers when accessing and engaging with health information, resources and supports in hospital outpatient waiting areas. Consumers’ ideas for designing a health literacy responsive waiting area were also evaluated. Themes and design typologies developed offered practical solutions which could be applied to future waiting area design. Overall, this thesis found that hospital outpatient waiting areas have potential to contribute to health literacy from the perspectives of consumers. However, in their current state, hospital outpatient waiting areas are not responsive to consumers’ diverse health literacy needs. The findings from this PhD research highlight future avenues for redesigning and coproducing health information, resources, supports and waiting area environments which are responsive to and inclusive of diverse health literacy needs.