Melbourne Medical School Collected Works - Research Publications
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ItemNo Preview AvailableUsing Graph-Based Signatures to Guide Rational Antibody Engineering.(Springer US, 2023)Antibodies are essential experimental and diagnostic tools and as biotherapeutics have significantly advanced our ability to treat a range of diseases. With recent innovations in computational tools to guide protein engineering, we can now rationally design better antibodies with improved efficacy, stability, and pharmacokinetics. Here, we describe the use of the mCSM web-based in silico suite, which uses graph-based signatures to rapidly identify the structural and functional consequences of mutations, to guide rational antibody engineering to improve stability, affinity, and specificity.
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ItemNo Preview AvailableThe reflected self(Karnac Books, 2015)
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ItemNo Preview AvailableChildren’s views of safety and adversity when living with domestic violence(Jessica Kingsley Publishers, 2015)
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ItemNo Preview AvailablePrevention and Mental Health Promotion in Adolescents: the evidence(McGraw Hill Australia, 2002)
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ItemNo Preview AvailableChild Development and Disability(Wiley Blackwell, 2015)Resident Medical Officers' Handbook, Lawson JS, ed. (Foreword: Sloan LEG). 100 p. Snap-lock ring binder. 2nd edition (1975–1976).Residents Handbook, Roy N, Vance J, eds. (Foreword: Sloan LEG). 203 p. Snap-lock ring binder.
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ItemNo Preview AvailableTeleconsultation and Telediagnosis for Oral Health Assessment: An Australian Perspective(SPRINGER, 2015-01-01)
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ItemMapping Biomedical Vocabularies: A Semi-Automated Term Matching Approach(IOS PRESS, 2014-01-01)Biomedical vocabularies vary in scope, and it is often necessary to utilize multiple vocabularies simultaneously in order to cover the full range of concepts relevant to a given biomedical application. However, as the number and size of these resources grow both redundancy (i.e., different vocabularies containing similar terms) and inconsistency (i.e., different terms in multiple vocabularies referring to the same entity) between the vocabularies increase. Therefore, there is a need for automatically aligning vocabularies. In this paper, we explore and propose new methods for detecting probable matches between two vocabularies. The methods build upon existing string similarity functions, enhancing these functions for the context of semi-automated vocabulary matching.
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ItemA Learning Design to Teach Scientific Inquiry(IGI Global, 2009)This chapter reports the authors’ experiences of developing a learning design to teach scientific inquiry, of integrating the learning design with learning objects to create online inquiry projects, and of investigating student attitudes following implementation in second year biochemistry units at a major Australian university. We discuss constructivism, problem based learning (PBL), and inquiry learning as the philosophical and pedagogical approaches informing the learning design, and highlight how critical components of each approach were transformed into a learning design. We specify the learning design and highlight its important features. The claimed efficiencies of the learning object approach were evaluated during the development phase. Outcomes reported here indicate that reuse was most cost effective if many, elaborate learning objects were reused. Little benefit was gained by the reuse of many, simple learning objects. Finally, student perceptions indicate benefits from the inquiry projects that warrant their inclusion in a traditional teacher-centred course.