Melbourne Medical School Collected Works - Research Publications
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ItemBaseline and follow-up assessment of regional left ventricular volume using 3-dimensional echocardiography: comparison with cardiac magnetic resonance(BIOMED CENTRAL LTD, 2009-11-19)The assessment of regional volumes is an option for analysis of the response of LV segments to interventions such as revascularization or cell therapy. We sought to compare regional volumes from 3D-echocardiography (3DE) with cardiac magnetic resonance (CMR) over follow-up. CMR regional volumes were assessed at baseline and after one year follow-up in 30 unselected patients (28 men, 65 +/- 11 years) presenting for evaluation of cardiac function with previous infarction. 3DE images were also gathered over 4 cardiac cycles and measurements were performed off-line. CMR images were obtained using a 1.5 Tesla scanner and measured offline by method of landmarks and by centre of mass. Regional volumes were measured at end-diastole (rEDV) and end-systole (rESV) and the change in volume was compared for each over follow-up. There was good correlation between 3DE and both CMR methods at baseline and follow-up. Changes in rEDV with 3DE vs CMR(L) were comparable (0.11 +/- 3 ml vs 0.12 +/- 3 ml, p = 0.94), as was change in CMR(M) (0.26 +/- 2 ml, p = 0.69). However the change in regional volume by 3DE and CMR(L) correlated poorly (r = 0.03, p = 0.68), as did change in 3DE vs CMR(M) (r = 0.04, p = 0.65). Similarly, changes in rESV with 3DE and CMR(L) were similar (0.27 +/- 2 ml vs 0.36 +/- 2 ml, p = 0.70), as was change in CMR(M) (0.05 +/- 1 ml, p = 0.31). Again, correlations between rESV by 3DE vs CMR(L) were poor (r = 0.03, p = 0.72), as well as 3DE vs CMR(M) (r = 0.07, p = 0.40). Although global 3DE volumes compare well with CMR volumes, new developments in image quality and automated software will be needed before changes in regional volumes can be reliably followed with 3DE.
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ItemInflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis(BMC, 2009)INTRODUCTION: Patients with recent-onset rheumatoid arthritis (RA) have impaired brachial artery endothelial function compared with controls matched for age, sex and cardiovascular risk factors. The present study examined endothelium-dependent (flow-mediated dilatation (FMD)) and independent (glyceryl trinitrate (GTN)-mediated dilatation (GMD)) structural responses in early RA patients, and determined progress over one year. METHODS: Brachial artery FMD and GMD and carotid intima media thickness (cIMT) were studied using ultrasound in 20 patients diagnosed with early RA in whom symptoms had been present for less than 12 months, and in 20 control subjects matched for age, sex and established cardiovascular risk factors. FMD and GMD were re-assessed after 12 months in RA patients and the change in each parameter was calculated. Data were analysed by univariate regression. RESULTS: Mean FMD and GMD were significantly lower in early RA patients at baseline than in controls, but each parameter significantly improved in one year. FMD and GMD responses were positively associated with each other. Patients' age, C-reactive protein (CRP) level and cIMT at baseline and CRP level at one year, were negatively associated with change in brachial responses in one year. CONCLUSIONS: Patients with recent-onset RA have altered brachial artery responses signifying both functional and structural abnormalities. However, early control of inflammation may reduce arterial dysfunction and thus the tendency for atherosclerotic progression.