Melbourne Medical School Collected Works - Research Publications

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Type: Preprint × Start date: 2020 × End date: 2020 × Author: Cowie, Benjamin ×

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    Breadth of concomitant immune responses underpinning viral clearance and patient recovery in a non-severe case of COVID-19
    Thevarajan, I ; Nguyen, THO ; Koutsakos, M ; Druce, J ; Caly, L ; van de Sandt, C ; Jia, X ; Nicholson, S ; Catton, M ; Cowie, B ; Tong, SYC ; Lewin, S ; Kedzierska, K ( 2020)
    We report the kinetics of the immune response in relation to clinical and virological features of a patient with mild-to-moderate coronavirus disease-19 (COVID-19) requiring hospitalisation. Increased antibody-secreting cells, follicular T-helper cells, activated CD4 + and CD8 + T-cells and IgM/IgG SARS-CoV-2-binding antibodies were detected in blood, prior to symptomatic recovery. These immunological changes persisted for at least 7 days following full resolution of symptoms, indicating substantial anti-viral immunity in this non-severe COVID-19.