Electrical and Electronic Engineering - Research Publications
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ItemComplex Correlation Measure: a novel descriptor for Poincare plot(BMC, 2009-08-13)BACKGROUND: Poincaré plot is one of the important techniques used for visually representing the heart rate variability. It is valuable due to its ability to display nonlinear aspects of the data sequence. However, the problem lies in capturing temporal information of the plot quantitatively. The standard descriptors used in quantifying the Poincaré plot (SD1, SD2) measure the gross variability of the time series data. Determination of advanced methods for capturing temporal properties pose a significant challenge. In this paper, we propose a novel descriptor "Complex Correlation Measure (CCM)" to quantify the temporal aspect of the Poincaré plot. In contrast to SD1 and SD2, the CCM incorporates point-to-point variation of the signal. METHODS: First, we have derived expressions for CCM. Then the sensitivity of descriptors has been shown by measuring all descriptors before and after surrogation of the signal. For each case study, lag-1 Poincaré plots were constructed for three groups of subjects (Arrhythmia, Congestive Heart Failure (CHF) and those with Normal Sinus Rhythm (NSR)), and the new measure CCM was computed along with SD1 and SD2. ANOVA analysis distribution was used to define the level of significance of mean and variance of SD1, SD2 and CCM for different groups of subjects. RESULTS: CCM is defined based on the autocorrelation at different lags of the time series, hence giving an in depth measurement of the correlation structure of the Poincaré plot. A surrogate analysis was performed, and the sensitivity of the proposed descriptor was found to be higher as compared to the standard descriptors. Two case studies were conducted for recognizing arrhythmia and congestive heart failure (CHF) subjects from those with NSR, using the Physionet database and demonstrated the usefulness of the proposed descriptors in biomedical applications. CCM was found to be a more significant (p = 6.28E-18) parameter than SD1 and SD2 in discriminating arrhythmia from NSR subjects. In case of assessing CHF subjects also against NSR, CCM was again found to be the most significant (p = 9.07E-14). CONCLUSION: Hence, CCM can be used as an additional Poincaré plot descriptor to detect pathology.
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ItemIdentifying diabetic patients with cardiac autonomic neuropathy by heart rate complexity analysis(BMC, 2009-01-29)BACKGROUND: Cardiac autonomic neuropathy (CAN) in diabetes has been called a "silent killer", because so few patients realize that they suffer from it, and yet its effect can be lethal. Early sub clinical detection of CAN and intervention are of prime importance for risk stratification in preventing sudden death due to silent myocardial infarction. This study presents the usefulness of heart rate variability (HRV) and complexity analyses from short term ECG recordings as a screening tool for CAN. METHODS: A total of 17 sets of ECG recordings during supine rest were acquired from diabetic subjects with CAN (CAN+) and without CAN (CAN-) and analyzed. Poincaré plot indexes as well as traditional time and frequency, and the sample entropy (SampEn) measure were used for analyzing variability (short and long term) and complexity of HRV respectively. RESULTS: Reduced (p > 0.05)_Poincaré plot patterns and lower (p < 0.05) SampEn values were found in CAN+ group, which could be a practical diagnostic and prognostic marker. Classification Trees methodology generated a simple decision tree for CAN+ prediction including SampEn and Poincaré plot indexes with a sensitivity reaching 100% and a specificity of 75% (percentage of agreement 88.24%). CONCLUSION: Our results demonstrate the potential utility of SampEn (a complexity based estimator) of HRV in identifying asymptomatic CAN.
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ItemA comparative study on approximate entropy measure and poincare plot indexes of minimum foot clearance variability in the elderly during walking(BMC, 2008-02-02)BACKGROUND: Trip-related falls which is a major problem in the elderly population, might be linked to declines in the balance control function due to ageing. Minimum foot clearance (MFC) which provides a more sensitive measure of the motor function of the locomotor system, has been identified as a potential gait parameter associated with trip-related falls in older population. This paper proposes nonlinear indexes (approximate entropy (ApEn) and Poincaré plot indexes) of MFC variability and investigates the relationship of MFC with derived indexes of elderly gait patterns. The main aim is to find MFC variability indexes that well correlate with balance impairments. METHODS: MFC data during treadmill walking for 14 healthy elderly and 10 elderly participants with balance problems and a history of falls (falls risk) were analysed using a PEAK-2D motion analysis system. ApEn and Poincaré plot indexes of all MFC data sets were calculated and compared. RESULTS: Significant relationships of mean MFC with Poincaré plot indexes (SD1, SD2) and ApEn (r = 0.70, p < 0.05; r = 0.86, p < 0.01; r = 0.74, p < 0.05) were found in the falls-risk elderly group. On the other hand, such relationships were absent in the healthy elderly group. In contrast, the ApEn values of MFC data series were significantly (p < 0.05) correlated with Poincaré plot indexes of MFC in the healthy elderly group, whereas correlations were absent in the falls-risk group. The ApEn values in the falls-risk group (mean ApEn = 0.18 +/- 0.03) was significantly (p < 0.05) higher than that in the healthy group (mean ApEn = 0.13 +/- 0.13). The higher ApEn values in the falls-risk group might indicate increased irregularities and randomness in their gait patterns and an indication of loss of gait control mechanism. ApEn values of randomly shuffled MFC data of falls risk subjects did not show any significant relationship with mean MFC. CONCLUSION: Results have implication for quantifying gait dynamics in normal and pathological conditions, thus could be useful for the early diagnosis of at-risk gait. Further research should provide important information on whether falls prevention intervention can improve the gait performance of falls risk elderly by monitoring the change in MFC variability indexes.
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ItemIdentification of onset, maximum and termination of obstructive sleep apnoea events in single lead ECG recordings(IEEE, 2008)Measuring the Apnoea Hypopnoea Index (AHI) is important for determining the severity of any apnoea patient. This study presents a method of screening each apnoea event separately based on the single lead Electrocardiogram (EGG) signal. The whole ECG of a subject was divided into Normal, Onset, OSA-maximum and Termination epochs with length of 5 seconds. PSD analysis was used for determining the features directly from the ECG. ROC area was calculated to determine the discrimination capability of each feature (or power in each frequency bin) found by PSD analysis. The maximum ROC area found between Normal vs. OSA-maximum was 0.81 in the frequency range of 52-72 Hz. The ROC area and significant frequency band for Normal vs. Onset and Normal vs. Termination were 0.78, 0.78 and 57-65 Hz, 52-66 Hz respectively.
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ItemAnalysis of coherence between sleep EEG and ECG signals during and after obstructive sleep apnea events(IEEE, 2008)This study presents the first successful preliminary attempt to directly investigate the interactions of power spectra of sleep EEG and ECG signals of patients with obstructive sleep apnea syndrome (OSAS) by coherence analysis. ECG and EEG signals were collected from 8 OSAS patients and 3 healthy subjects. Coherence between two signals over different frequency bands(0-128 Hz) were calculated for normal breathing events, obstructive sleep apnea (OSA) events and events following OSA terminations (with/without arousals) in non-REM as well as REM sleep. Overall coherence of ECG and EEG in REM sleep is higher than that in non-REM sleep. A significant (p=0.0164) difference of coherence in the range of 10-5 Hz was found among normal, OSA and termination events in REM sleep. The results could be useful in detecting OSA events or OSA related arousals to characterize sleep fragmentation from ECG and EEG signals.
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