Electrical and Electronic Engineering - Research Publications
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ItemDisplay of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination.(American Association of Immunologists, 2020-10-01)Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property has also occasionally been attributed to conventional dendritic cells (cDC) but is generally masked by their essential role in T cell priming. cDC can be divided into two main subsets, cDC1 and cDC2, with recent evidence suggesting that cDC2 are primarily responsible for initiating B cell and T follicular helper responses. This conclusion is, however, at odds with evidence that targeting Ag to Clec9A (DNGR1), expressed by cDC1, induces strong humoral responses. In this study, we reveal that murine cDC1 interact extensively with B cells at the border of B cell follicles and, when Ag is targeted to Clec9A, can display native Ag for B cell activation. This leads to efficient induction of humoral immunity. Our findings indicate that surface display of native Ag on cDC with access to both T and B cells is key to efficient humoral vaccination.
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ItemK-EmoCon, a multimodal sensor dataset for continuous emotion recognition in naturalistic conversations.(Springer Science and Business Media LLC, 2020-09-08)Recognizing emotions during social interactions has many potential applications with the popularization of low-cost mobile sensors, but a challenge remains with the lack of naturalistic affective interaction data. Most existing emotion datasets do not support studying idiosyncratic emotions arising in the wild as they were collected in constrained environments. Therefore, studying emotions in the context of social interactions requires a novel dataset, and K-EmoCon is such a multimodal dataset with comprehensive annotations of continuous emotions during naturalistic conversations. The dataset contains multimodal measurements, including audiovisual recordings, EEG, and peripheral physiological signals, acquired with off-the-shelf devices from 16 sessions of approximately 10-minute long paired debates on a social issue. Distinct from previous datasets, it includes emotion annotations from all three available perspectives: self, debate partner, and external observers. Raters annotated emotional displays at intervals of every 5 seconds while viewing the debate footage, in terms of arousal-valence and 18 additional categorical emotions. The resulting K-EmoCon is the first publicly available emotion dataset accommodating the multiperspective assessment of emotions during social interactions.
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ItemModel based estimation of QT intervals in non-invasive fetal ECG signals.(Public Library of Science (PLoS), 2020)The end timing of T waves in fetal electrocardiogram (fECG) is important for the evaluation of ST and QT intervals which are vital markers to assess cardiac repolarization patterns. Monitoring malignant fetal arrhythmias in utero is fundamental to care in congenital heart anomalies preventing perinatal death. Currently, reliable detection of end of T waves is possible only by using fetal scalp ECG (fsECG) and fetal magnetocardiography (fMCG). fMCG is expensive and less accessible and fsECG is an invasive technique available only during intrapartum period. Another safer and affordable alternative is the non-invasive fECG (nfECG) which can provide similar assessment provided by fsECG and fMECG but with less accuracy (not beat by beat). Detection of T waves using nfECG is challenging because of their low amplitudes and high noise. In this study, a novel model-based method that estimates the end of T waves in nfECG signals is proposed. The repolarization phase has been modeled as the discharging phase of a capacitor. To test the model, fECG signals were collected from 58 pregnant women (age: (34 ± 6) years old) bearing normal and abnormal fetuses with gestational age (GA) 20-41 weeks. QT and QTc intervals have been calculated to test the level of agreement between the model-based and reference values (fsECG and Doppler Ultrasound (DUS) signals) in normal subjects. The results of the test showed high agreement between model-based and reference values (difference < 5%), which implies that the proposed model could be an alternative method to detect the end of T waves in nfECG signals.
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ItemThe Role of Visual Assessment of Clusters for Big Data Analysis: From Real-World Internet of Things(Institute of Electrical and Electronics Engineers (IEEE), 2020-10)The Internet of Things (IoT) is playing a vital role in shaping today?s technological world, including our daily lives. By 2025, the number of connected devices due to the IoT is estimated to surpass a whopping 75 billion. It is a challenging task to discover, integrate, and interpret processed big data from such ubiquitously available heterogeneous and actively natural resources and devices. Cluster analysis of IoT-generated big data is essential for the meaningful interpretation of such complex data. However, we often have very limited knowledge of the number of clusters actually present in the given data. The problem of finding whether clusters are present even before applying clustering algorithms is termed the assessment of clustering tendency. In this article, we present a set of useful visual assessment of cluster tendency (VAT) tools and techniques developed with major contributions from James C. Bezdek. The article further highlights how these techniques are advancing the IoT through large-scale IoT implementations.
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ItemAutomated Scoring of Hemiparesis in Acute Stroke From Measures of Upper Limb Co-Ordination Using Wearable Accelerometry.(Institute of Electrical and Electronics Engineers, 2020-04)Stroke survivors usually experience paralysis in one half of the body, i.e., hemiparesis, and the upper limbs are severely affected. Continuous monitoring of hemiparesis progression hours after the stroke attack involves manual observation of upper limb movements by medical experts in the hospital. Hence it is resource and time intensive, in addition to being prone to human errors and inter-rater variability. Wearable devices have found significance in automated continuous monitoring of neurological disorders like stroke. In this paper, we use accelerometer signals acquired using wrist-worn devices to analyze upper limb movements and identify hemiparesis in acute stroke patients, while they perform a set of proposed spontaneous and instructed movements. We propose novel measures of time (and frequency) domain coherence between accelerometer data from two arms at different lags (and frequency bands). These measures correlate well with the clinical gold standard of measurement of hemiparetic severity in stroke, the National Institutes of Health Stroke Scale (NIHSS). The study, undertaken on 32 acute stroke patients with varying levels of hemiparesis and 15 healthy controls, validates the use of short length (< 10 minutes) accelerometry data to identify hemiparesis through leave-one-subject-out cross-validation based hierarchical discriminant analysis. The results indicate that the proposed approach can distinguish between controls, moderate and severe hemiparesis with an average accuracy of 91%.
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ItemVision-based automated crack detection using convolutional neural networks for condition assessment of infrastructure(SAGE PUBLICATIONS LTD, 2020-11-01)With the growing number of aging infrastructure across the world, there is a high demand for a more effective inspection method to assess its conditions. Routine assessment of structural conditions is a necessity to ensure the safety and operation of critical infrastructure. However, the current practice to detect structural damages, such as cracks, depends on human visual observation methods, which are prone to efficiency, cost, and safety concerns. In this article, we present an automated detection method, which is based on convolutional neural network models and a non-overlapping window-based approach, to detect crack/non-crack conditions of concrete structures from images. To this end, we construct a data set of crack/non-crack concrete structures, comprising 32,704 training patches, 2074 validation patches, and 6032 test patches. We evaluate the performance of our approach using 15 state-of-the-art convolutional neural network models in terms of number of parameters required to train the models, area under the curve, and inference time. Our approach provides over 95% accuracy and over 87% precision in detecting the cracks for most of the convolutional neural network models. We also show that our approach outperforms existing models in literature in terms of accuracy and inference time. The best performance in terms of area under the curve was achieved by visual geometry group-16 model (area under the curve = 0.9805) and best inference time was provided by AlexNet (0.32 s per image in size of 256 × 256 × 3). Our evaluation shows that deeper convolutional neural network models have higher detection accuracies; however, they also require more parameters and have higher inference time. We believe that this study would act as a benchmark for real-time, automated crack detection for condition assessment of infrastructure.
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ItemDetermination of the electrical impedance of neural tissue from its microscopic cellular constituents(IOP Publishing, 2020-02-01)The electrical properties of neural tissue are important in a range of different applications in biomedical engineering and basic science. These properties are characterized by the electrical admittivity of the tissue, which is the inverse of the specific tissue impedance. Objective. Here we derived analytical expressions for the admittivity of various models of neural tissue from the underlying electrical and morphological properties of the constituent cells. Approach. Three models are considered: parallel bundles of fibers, fibers contained in stacked laminae and fibers crossing each other randomly in all three-dimensional directions. Main results. An important and novel aspect that emerges from considering the underlying cellular composition of the tissue is that the resulting admittivity has both spatial and temporal frequency dependence, a property not shared with conventional conductivity-based descriptions. The frequency dependence of the admittivity results in non-trivial spatiotemporal filtering of electrical signals in the tissue models. These effects are illustrated by considering the example of pulsatile stimulation with a point source electrode. It is shown how changing temporal parameters of a current pulse, such as pulse duration, alters the spatial profile of the extracellular potential. In a second example, it is shown how the degree of electrical anisotropy can change as a function of the distance from the electrode, despite the underlying structurally homogeneity of the tissue. These effects are discussed in terms of different current pathways through the intra- and extra-cellular spaces, and how these relate to near- and far-field limits for the admittivity (which reduce to descriptions in terms of a simple conductivity). Significance. The results highlight the complexity of the electrical properties of neural tissue and provide mathematical methods to model this complexity.
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ItemOn the Latency, Rate and Reliability Tradeoff in Wireless Networked Control Systems for IIoT(Institute of Electrical and Electronics Engineers (IEEE), 2020)Wireless networked control systems (WNCSs) provide a key enabling technique for Industry Internet of Things (IIoT). However, in the literature of WNCSs, most of the research focuses on the control perspective, and has considered oversimplified models of wireless communications which do not capture the key parameters of a practical wireless communication system, such as latency, data rate and reliability. In this paper, we focus on a WNCS, where a controller transmits quantized and encoded control codewords to a remote actuator through a wireless channel, and adopt a detailed model of the wireless communication system, which jointly considers the inter-related communication parameters. We derive the stability region of the WNCS. If and only if the tuple of the communication parameters lies in the region, the average cost function, i.e., a performance metric of the WNCS, is bounded. We further obtain a necessary and sufficient condition under which the stability region is n-bounded, where n is the control codeword blocklength. We also analyze the average cost function of the WNCS. Such analysis is non-trivial because the finite-bit control-signal quantizer introduces a non-linear and discontinuous quantization function which makes the performance analysis very difficult. We derive tight upper and lower bounds on the average cost function in terms of latency, data rate and reliability. Our analytical results provide important insights into the design of the optimal parameters to minimize the average cost within the stability region.
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ItemAdaptive Scan for Atomic Force Microscopy Based on Online Optimization: Theory and Experiment(Institute of Electrical and Electronics Engineers, 2020-05-01)A major challenge in atomic force microscopy is to reduce the scan duration while retaining the image quality. Conventionally, the scan rate is restricted to a sufficiently small value in order to ensure a desirable image quality as well as a safe tip-sample contact force. This usually results in a conservative scan rate for samples that have a large variation in aspect ratio and/or for scan patterns that have a varying linear velocity. In this paper, an adaptive scan scheme is proposed to alleviate this problem. A scan line-based performance metric balancing both imaging speed and accuracy is proposed, and the scan rate is adapted such that the metric is optimized online in the presence of aspect ratio and/or linear velocity variations. The online optimization is achieved using an extremum-seeking approach, and a semiglobal practical asymptotic stability result is shown for the overall system. Finally, the proposed scheme is demonstrated via both simulation and experiment.
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ItemSecurity metrics and synthesis of secure control systems(Elsevier Inc., 2020-05-01)The term stealthy has come to encompass a variety of techniques that attackers can employ to avoid being detected. In this manuscript, for a class of perturbed linear time-invariant systems, we propose two security metrics to quantify the potential impact that stealthy attacks could have on the system dynamics by tampering with sensor measurements. We provide analysis tools to quantify these metrics for given system dynamics, control, and system monitor. Then, we provide synthesis tools (in terms of semidefinite programs) to redesign controllers and monitors such that the impact of stealthy attacks is minimized and the required attack-free system performance is guaranteed.