 Electrical and Electronic Engineering  Research Publications
Electrical and Electronic Engineering  Research Publications
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ItemReal value solvent accessibility prediction using adaptive support vector regressionGubbi, J ; Shilton, A ; Palaniswami, M ; Parker, M (IEEE, 20070101)

ItemProtein topology classification using twostage support vector machines.Gubbi, J ; Shilton, A ; Parker, M ; Palaniswami, M (Universal Academy Press, 2006)The determination of the first 3D model of a protein from its sequence alone is a nontrivial problem. The first 3D model is the key to the molecular replacement method of solving phase problem in xray crystallography. If the sequence identity is more than 30%, homology modelling can be used to determine the correct topology (as defined by CATH) or fold (as defined by SCOP). If the sequence identity is less than 25%, however, the task is very challenging. In this paper we address the topology classification of proteins with sequence identity of less than 25%. The input information to the system is amino acid sequence, the predicted secondary structure and the predicted real value relative solvent accessibility. A two stage support vector machine (SVM) approach is proposed for classifying the sequences to three different structural classes (alpha, beta, alpha+beta) in the first stage and 39 topologies in the second stage. The method is evaluated using a newly curated dataset from CATH with maximum pairwise sequence identity less than 25%. An impressive overall accuracy of 87.44% and 83.15% is reported for class and topology prediction, respectively. In the class prediction stage, a sensitivity of 0.77 and a specificity of 0.91 is obtained. Data file, SVM implementation (SVMHEAVY) and result files can be downloaded from http://www.ee.unimelb.edu.au/ISSNIP/downloads/.

ItemStability Analysis of the Decomposition Method for solving Support Vector MachinesLai, Daniel ; SHILTON, ALISTAIR ; Mani, N. ; PALANISWAMI, MARIMUTHU ( 2005)In situations where processing memory is limited, the Support Vector Machine quadratic program can be decomposed into smaller subproblems and solved sequentially. The convergence of this method has been proven previously through the use of a counting method. In this initial investigation, we approach the convergence analysis by treating the decomposed subproblems as subsystems of a general system. The gradients of the subproblems and the inequality constraints are explicitly modelled as system variables. The change in these variables during optimization form a dynamic system modelled by vector differential equations. We show that the change in the objective function can be written as the energy in the system. This makes it a natural Lyapunov function which has an asymptotically stable point at the origin. The asymptotic stability of the whole system then follows under certain assumptions.

ItemDisulphide Bridge Prediction using Fuzzy Support Vector MachinesJayavardhana, Rama G. L. ; SHILTON, ALISTAIR ; PARKER, MICHAEL ; PALANISWAMI, MARIMUTHU ( 2005)One of the major contributors to the native form of protien is cystines forming covalent bonds in oxidized state. The Prediction of such bridges from the sequence is a very challenging task given that the number of bridges will rise exponentially as the number of cystines increases. We propose a novel technique for disulphide bridge prediction based on Fuzzy Support Vector Machines. We call the system DIzzy. In our investigation, we look at disulphide bond connectivity given two Cystines with and without a priori knowledge of the bonding state. We make use of a new encoding scheme based on physicochemical properties and statistical features such as the probability of occurrence of each amino acid in different secondary structure states along with psiblast profiles. The performance is compared with normal support vector machines. We evaluate our method and compare it with the existing method using SPX dataset.

ItemDistributed data fusion using support vector machinesChalla, S. ; Palaniswami, M. ; Shilton, A. ( 2002)The basic quantity to be estimated in the Bayesian approach to data fusion is the conditional probability density function (CPDF). In recent times, computationally efficient particle filtering approaches are gaining growing importance in estimating these CPDF. In this approach, i.i.d samples are used to represent the conditional probability densities. However, their application in data fusion is severely limited due to the fact that the information is stored in the form of a large set of samples. In all practical data fusion systems that have limited communication bandwidth, broadcasting this probabilistic information, available as a set of samples, to the fusion center is impractical. Support vector machines, through statistical learning theory, provide a way of compressing information by generating optimal kernal based representations. In this paper we use SVM to compress the probabilistic information available in the form of i.i.d samples and apply it to solve the Bayesian data fusion problem. We demonstrate this technique on a multisensor tracking example.

ItemMachine learning using support vector machinesPalaniswami, M. ; Shilton, A. ; Ralph, D. ; Owen, B. D. ( 2000)Machine learning invokes the imagination of many scientific minds due to its potential to solve complex and difficult real world problems. This paper gives methods of constructing machine learning tools using Support Vector Machines (SVMs). We first give a simple example to illustrate the basic concept and then demonstrate further with a practical problem. The practical problem is concerned with electronic monitoring of fishways for automatic counting of different fish species for the purpose of environmental management in Australian rivers. The results illustrate the power of the SVM approaches on the sample problem and their computational attractiveness for practical implementations.

ItemA convergence rate estimate for the SVM decomposition methodLai, D. ; Shilton, A. ; Palaniswami, M. ( 2005)The training of Support Vector Machines using the decomposition method has one drawback; namely the selection of working sets such that convergence is as fast as possible. It has been shown by Lin that the rate is linear in the worse case under the assumption that all bounded Support Vectors have been determined. The analysis was done based on the change in the objective function and under a SVMlight selection rule. However, the rate estimate given is independent of time and hence gives little indication as to how the linear convergence speed varies during the iteration. In this initial analysis, we provide a treatment of the convergence from a gradient contraction perspective. We propose a necessary and sufficient condition which when satisfied provides strict linear convergence of the algorithm. The condition can also be interpreted as a basic requirement for a sequence of working sets in order to achieve such a convergence rate. Based on this condition, a time dependant rate estimate is then further derived. This estimate is shown to monotonically approach unity from below.

ItemModified nuSV Method for Simplified RegressionShilton, A. ; Palaniswami, M. ( 2004)In the present paper we describe a new algorithm for Support Vector Regression (SVR). Like the standard nuSVR algorithms, this algorithm automatically adjusts the radius of insensitivity (tube width epsilon) to fit the data. However, this is achieved without additional complexity in the optimisation problem. Moreover, by careful modification of the kernel function, we are able to significantly simplify the form of the dual SVR optimisation problem.

ItemAdaptive support vector machines for regressionPalaniswami, M. ; Shilton, A. ( 2002)Support Vector Machines are a general formulation for machine learning. It has been shown to perform extremely well for a number of problems in classification and regression. However, in many difficult problems, the system dynamics may change with time and the resulting new information arriving incrementally will provide additional data. At present, there is limited work to cope with the computational demands of modeling time varying systems. Therefore, we develop the concept of adaptive support vector machines that can learn from incremental data. In this paper, results are provided to demonstrate the applicability of the adaptive support vector machines techniques for pattern classification and regression problems.