Surgery (Austin & Northern Health) - Theses

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End date: 2009 × Type: PhD thesis × Subject: colorectal liver metastases ×

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    The effect of laser induced thermal ablation on liver tumours
    NIKFARJAM, MEHRDAD ( 2005-11)
    Laser thermal ablation (LTA) is an in situ ablative technique that induces heat destruction of liver tumours. Despite increasing clinical use of LTA, reports of long-term outcomes and limitation of treatment in specific cohorts of patients with liver tumours are lacking. In addition, the mechanisms of action of therapy have not been fully elucidated. This study highlights the long-term clinical results and limitations of LTA in the treatment of a cohort of patients with unresectable colorectal liver metastases and examines the mechanisms of action of thermal ablative injury in a murine model.