Ophthalmology (Eye & Ear Hospital) - Research Publications

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Start date: 2000 × Author: Vajpayee, Rasik × Author: Jhanji, Vishal ×

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    Amniotic membrane transplantation with or without autologous cultivated limbal stem cell transplantation for the management of partial limbal stem cell deficiency
    Sharma, N ; Mohanty, S ; Jhanji, V ; Vajpayee, RB (DOVE MEDICAL PRESS LTD, 2018)
    PURPOSE: To compare the outcomes of amniotic membrane transplantation (AMT) vs cultivated limbal stem cell transplantation (LSCT) in eyes with partial limbal stem cell deficiency (LSCD) following chemical burns. METHODS: Eyes with unilateral partial LSCD (#180° involvement) were randomized in two groups to undergo either pannus resection combined with AMT or pannus resection combined with LSCT in a tertiary eye care hospital. Primary outcome measures were time to corneal epithelialization and absence of conjunctivalization of the cornea. Patients were followed up at 1 week, 1, 3, 6, and 12 months after the surgical procedure. RESULTS: There was no difference between mean age (30.85±5.8 vs 28.64±6.4 years, P=0.40) and sex distribution of patients between the two groups at baseline. Mean time to corneal epithelialization was 10.45±5.8 days in the AMT group and 11±3.9 days in the LSCT group (P=0.43). At the end of 1 year, there was no significant difference between the degree of conjunctivalization of cornea, (P=0.06) corneal vascularization, (P=0.08), and clarity (P=0.07) in both groups. CONCLUSION: Our study showed that AMT alone is a useful therapeutic modality in cases with partial LSCD due to ocular chemical injury. Stem cell transplantation may not be required in these cases.
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    Infectious corneal ulceration: a proposal for neglected tropical disease status
    Ung, L ; Acharya, NR ; Agarwal, T ; Alfonso, EC ; Bagga, B ; Bispo, PJM ; Burton, MJ ; Dart, JKG ; Thuy, D ; Fleiszig, SMJ ; Garg, P ; Gilmore, MS ; Gritz, DC ; Hazlett, LD ; Iovieno, A ; Jhanji, V ; Kempen, JH ; Lee, CS ; Lietman, TM ; Margolis, TP ; McLeod, SD ; Mehta, JS ; Miller, D ; Pearlman, E ; Prajna, L ; Prajna, NV ; Seitzman, GD ; Shanbhag, SS ; Sharma, N ; Sharma, S ; Srinivasan, M ; Stapleton, F ; Tan, DTH ; Tandon, R ; Taylor, HR ; Tu, EY ; Tuli, SS ; Vajpayee, RB ; Van Gelder, RN ; Watson, SL ; Zegans, ME ; Chodosh, J (WORLD HEALTH ORGANIZATION, 2019-12)
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    First contact diagnosis and management of contact lens-related complications.
    Fagan, XJ ; Jhanji, V ; Constantinou, M ; Amirul Islam, FM ; Taylor, HR ; Vajpayee, RB (Springer Science and Business Media LLC, 2012-08)
    To describe the spectrum of contact lens-related problems in cases presenting to a tertiary referral eye hospital. A retrospective case record analysis of 111 eyes of 97 consecutive patients was undertaken over a period of five months at the Royal Victorian Eye and Ear Hospital, Melbourne, Australia. Contact lens-related complications (CLRC) were classified into microbial keratitis, sterile corneal infiltrates, corneal epitheliopathy and contact lens-related red eye (CLARE). Main parameters examined were nature of the first contact, clinical diagnosis, and management pattern. Forty-two percent of the initial presentations were to health care practitioners (HCPs) other than ophthalmologists. Mean duration from the onset of symptoms to presentation was 6.3 ± 10.9 days. Forty-nine percent (n = 54) of patients had an associated risk factor, most commonly overnight use of contact lenses (n = 14, 13 %). Most common diagnosis at presentation was corneal epitheliopathy (68 %) followed by sterile infiltrates (10 %), CLARE (8 %) and microbial keratitis (6 %). No significant differences were found in the pattern of treatment modalities administered by ophthalmologists and other HCPs. HCPs other than ophthalmologists are the first contact for contact lens-related problems in a significant proportion of patients. These HCPs manage the majority of CLRC by direct treatment or immediate referral.