Chancellery Research - Research Publications
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ItemEncountering a Pedagogy of the World in a University Setting(Taylor & Francis, 2021)Taking up Biesta’s (2019) notion of a pedagogy of the world, we ask: How might participating in an arts-based educational program with/in a university enable young people from schools with low Index of Community Socio-Educational Advantage (ICSEA) values to encounter the world of higher education differently and become different in that encounter? This chapter comes from our engagement with empirical material generated during a (post)qualitative inquiry into the pedagogy of The Art of Engagement-a multi-arts studio program involving relational pedagogy and a/r/tography as curriculum located in SPACE, 1 whereby secondary school students from schools in less socio-educationally advantaged communities came together with undergraduate university students for a five-day intensive within a University of Melbourne breadth subject. The program’s rationale was to connect with secondary school arts students completing their schooling in lower ICSEA value schools 2 through the design of authentic university encounters with/in site, practices and communities. It welcomed the secondary school students into the world of our university and enhanced their capacity to “be at home” in this world, creating the conditions for considering and potentially living different post-school futures.
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ItemNo Preview AvailableCognition in healthy older women is a predictor of 14‐year falls risk(Wiley, 2021-12)Background: Falls are a significant cause of injuries, loss of confidence, increased morbidity, and institutionalisation in all older people, with women at 50% greater risk than men. The relationship between dementia and falls is well established and 2/3 of all dementia occurs in women. In this study we explored risk factors associated with a 14 year falls risk in a community-based cohort of women, which included validated measures across a wide range of clinical domains including neuropsychological, mood, quality of life and biomarkers (including hormonal). Method: The Australian Women’s Healthy Aging Project is an longitudinal observation study, assessments every year (1991 –1999), followed by assessments in 2002, 2004, 2012 and 2014. The assessments included cognitive (as of 2002), blood, and cardiovascular disease risk assessment, and questions related to falls. After data cleaning, the remaining cohort consisted of 180 participants (Table 1). Missing data were imputed using mice random forest. To identify key risk factors associated with a 14 year falls risk, random survival (time to event) forest (RSF) machine learning was used. Result: The RSF model, using all 290+ possible predictive variables, performed well with an Out Of Bag (OOB, withheld data) prediction error (C-index) of 32.8%. The most predictive variables in the model were identified using the variable importance measure (VIM). The initial model was refined by taking the top 30 predictive variables and retraining the RSF. This refined model resulted in an improved OOB C-index of 5.8% (27%). The top 20 predictive variables, Figure 1, include those associated with cardiovascular disease risk, cognitive performance, and hormone levels (e.g., family history of heart attack, digit symbol coding, and estradiol levels). Conclusion: Ninety percent of the top 20 predictive risk variables for the 14 year fall risk in women, were from three key domains, cognition (40%), cardiovascular (25%) and hormone-related measurements (25%). Our data suggest that for long term prevention of falls these domains may be important reducing risk of falls in the senior female population.
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ItemThe establishment of a cytomegalovirus -specific CD8(+) T-cell threshold by kinetic modeling for the prediction of post-hemopoietic stem cell transplant reactivation(CELL PRESS, 2022-10-26)The dynamic interaction between the CMV virus and host immune response remains obscure, thus hindering the diagnosis and therapeutic management of patients with HSCT. The current diagnosis of CMV viremia depends on viral load estimation. Medical intervention based on viral load, can be unnecessary or poorly timed for many patients. Here we examined the clinical features and blood samples of patients with HSCT and assessed the CMV reactivation kinetics and corresponding CMV antigen-specific T-cell response in individual patients based on a peptide pool stimulation T-cell assay, which showed that CMV-specific CD8+ T cells were more suitable to be a diagnosis indicator for suppressing CMV reactivation. Using ROC analysis, we defined and verified a CMV-specific CD8+ T-cell counts threshold (925 cells/106 PBMCs) as an indicator of CMV reactivation post-HSCT, and suggested that use of this threshold would provide more accurate guidance for prompt medication and better management of CMV infection post-HSCT.
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ItemNo Preview AvailableDual TCR-alpha Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation(AMER ASSOC IMMUNOLOGISTS, 2022-03-15)Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT cells have an invariant TCRα-chain that uses T cell receptor α-variable 1-2 (TRAV1-2) joined to TRAJ33/20/12 and recognizes metabolites from bacterial riboflavin synthesis bound to the Ag-presenting molecule MHC class I related (MR1). Our attempts to identify alternative MR1-presented Ags led to the discovery of rare MR1-restricted T cells with non-TRAV1-2 TCRs. Because altered Ag specificity likely alters affinity for the most potent known Ag, 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU), we performed bulk TCRα- and TCRβ-chain sequencing and single-cell-based paired TCR sequencing on T cells that bound the MR1-5-OP-RU tetramer with differing intensities. Bulk sequencing showed that use of V genes other than TRAV1-2 was enriched among MR1-5-OP-RU tetramerlow cells. Although we initially interpreted these as diverse MR1-restricted TCRs, single-cell TCR sequencing revealed that cells expressing atypical TCRα-chains also coexpressed an invariant MAIT TCRα-chain. Transfection of each non-TRAV1-2 TCRα-chain with the TCRβ-chain from the same cell demonstrated that the non-TRAV1-2 TCR did not bind the MR1-5-OP-RU tetramer. Thus, dual TCRα-chain expression in human T cells and competition for the endogenous β-chain explains the existence of some MR1-5-OP-RU tetramerlow T cells. The discovery of simultaneous expression of canonical and noncanonical TCRs on the same T cell means that claims of roles for non-TRAV1-2 TCR in MR1 response must be validated by TCR transfer-based confirmation of Ag specificity.
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ItemNo Preview AvailableInvestigation of the Extraction of Natural Alkaloids in Karr Reciprocating Hate Columns: Mass Transfer Study(TAYLOR & FRANCIS INC, 2022-09-18)
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ItemNo Preview AvailableCollaborative Development of Polymer-Based Collection Survey Methodology and Relational Data Model(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2022-03-15)
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ItemNo Preview AvailableInvestigation of green solvents for the extraction of phenol and natural alkaloids: Solvent and extractant selection(ELSEVIER SCIENCE SA, 2022-08-15)
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ItemNo Preview Available?Spring is the best time to lose weight?: Evidence that dieting is seasonal and reaches peak intensity during Spring(ELSEVIER, 2022-05-05)Does dieting intensify during Spring? Previous research suggests that body dissatisfaction is seasonal and peaks during Summer. Extending these findings to seasonal dieting, we contend that individuals' apprehensions about heightened Summertime body dissatisfaction motivate Springtime dieting. To detect seasonal dieting, we examined the seasonal frequencies of 69 dieting hashtags within a database of 564 million tweets originating from the United States and spanning eight calendar years (2012-19). In total, we detected 628,355 dieting hashtags. Of these, 30% occurred during Spring, 20% during Autumn/Fall, and 25% during each of Summer and Winter. During Spring, there were ~64,000 additional dieting hashtags compared with Autumn/Fall, and ~32,000 additional hashtags compared with Summer and Winter. Of the nine most common dieting hashtags that together accounted for 96% of the total, all nine peaked during Spring (ps < 0.0001). This Spring-centric pattern was apparent for both appearance-oriented diets (e.g., "atkins" and "weightwatchers") and ostensibly non-appearance-oriented diets (e.g., "vegan" and "glutenfree"), suggesting that non-appearance-oriented diets might nonetheless be co-opted for appearance-oriented purposes. In conclusion, we found credible evidence that dieting intensifies during Spring. Future research should examine whether eating disorders and muscle dysmorphia also intensify during Spring because dieting is intrinsic to both these conditions.
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ItemNo Preview AvailableImmediate Text Search on Streams Using Apoptosic Indexes(SPRINGER INTERNATIONAL PUBLISHING AG, 2022-01-01)