We employ the newly developed Matrix Product State (MPS) formalism to simulate two problems in the context of quantum information processing. One is the Boson sampling problem, the other is the ground state energy density of an n-qubit Hamiltonian. We find that the MPS representation of the Boson sampling problem is inefficient due to large entan- glement as the number of photons increases. In the context of adiabatic quantum computing (AQC), MPS is used to find the first four moments of an n-qubit Hamiltonian to approximate the ground state energy density of the Hamiltonian. We show an advantage of using the first-four-moment method over the conventional adiabatic procedure. Future work around AQC using MPS is discussed.