Physiology - Theses

Permanent URI for this collection

http://hdl.handle.net/11343/185

Filters

2005 1
1
Reset filters

Settings
Statistics
Citations
Subject: angiotensin × Author: Domenighetti, Andrea A. ×

Search Results

Now showing 1 - 1 of 1
  • Item
    Thumbnail Image
    Characterization of mechanisms of myocardial remodeling in genetic models of cardiac hypertrophy
    Domenighetti, Andrea A. ( 2005-12)
    Cardiac hypertrophy is clinically defined as a relative increase in heart size associated with a thickening of the ventricular wall. It is a common feature of individuals suffering from different cardio-vascular or metabolic conditions and leads to heart failure. The structural, functional and molecular mechanisms which induce hypertrophy independent of hemodynamic alterations are poorly characterized. In this study, questions about whether cardiac-specific neuro-endocrine activation or metabolic imbalance are sufficient to induce hypertrophic structural and functional remodeling are addressed using genetically manipulated mouse models of primary cardiac hypertrophy. (For complete abstract open document)