Graeme Clark Collection
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ItemCochlear implants in children: the value of cochleostomy seals in the prevention of labyrinthitis following pneumococcal otitis media( 1995)Cochlea implantation at an early age is important in rehabilitating profoundly hearing impaired children. Given the incidence of pneumococcal otitis media in young children, there has been concern that cochlear implantation could increase the possibility of otitis media, leading to labyrinthitis in this age group. Clinical experience has not indicated an increase in the frequency of otitis media and labyrinthitis in implanted adults or children over two years. However, labyrinthitis has occurred in implanted animals with otitis media. In order to assess the impact of cochlear implants on the occurrence of labyrinthitis, pneumococcal otitis media was induced in 21 kittens. Thirty-two kitten cochleas were implanted, of which 9 had a fascial graft and 9 a Gelfoam® graft. Nine control cochleas were unimplanted. Labyrinthitis occurred in 44% of unimplanted controls. 50% of implanted ungrafted cochleas, and 6% of implanted grafted cochleas. There was no statistically significant difference between the incidence of labyrinthitis in the implanted cochleas and the unimplanted controls. However there was a statistically significant difference between the ungrafted and grafted cochleas, but not between the two types of graft.
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ItemCochlear implantation in young children: histological studies on head growth, leadwire design, and electrode fixation in the monkey model( 1994)For safe cochlear implantation in children under 2 years of age, the implant assembly must not adversely affect adjacent tissues or compromise head growth. Furthermore, growth changes and tissue responses should not impair the function of the device. Dummy receiver-stimulators, interconnect plugs, and leadwire-lengthening systems were implanted for periods of 36 months in the young monkey to effectively model the implantation of the young child. The results show that implanting a receiver-stimulator package has no adverse effects on skull growth or the underlying central nervous system. The system for fixing the electrode at the fossa incudis proved effective. There was marked osteoneogenesis in the mastoid cavity, resulting in the fixation of the leadwire outside the cochlea. This study provides evidence for the safety of cochlear implantation in young subjects.
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ItemCochlear implantation in children: the risk of pneumococcal otitis media [Abstract]( 1992)Pneumococcal otitis media is most frequent in young children and is a matter of concern in cochlear implantation. In the course of the 'implantation surgery the physiological barrier between the middle ear and inner ear is broken down by incising the round window membrane or by fenestration of the cochlear wall. It is feared that the insertion of an electrode array into the scala tympani could provide a pathway for microorganisms and toxins to enter the cochlea, resulting in labyrinthitis. To assess the actual risk of, secondary inner ear infection post implantation we developed a cat animal model of otitis media. In addition we examined the, effectiveness of different sealing strategies compared to the alternative of leaving the electrode entry point unprotected. For sealing of the cochlea fibrous tissue or gelatine foam was wrapped around the electrode in the round window niche. 22 kittens (44 ears) were used for this study 32, ears were implanted at 2 months of age, and all 44 ears were inoculated after 2 months with a broth of, streptococcus pneumoniae and the animals sacrificed one week later. The bullae of the animals were swabbed and the cochleas processed and examined under light microscopy. Histological analysis of the cochleas showed ,the� highest incidence (45%) of labyrinthine spread of infection in the unimplanted control group. Suppurative or serous labyrinthitis was found in only one third (33.3%) of the implanted and unsealed cochleas. In contrast only one of 16 sealed cochleas, (6.2 %) showed labyrinthine signs of acute inflammation. Experimental pneumococcal otitis media could be reliably established in all animals and proved to be a valuable animal model for the testing of the intracochlear spread of infection. We conclude that a cochlear implant electrode inserted via the round window does not increase the risk of tympanogenic abyrinthitis. Our results indicate that grafting of the electrode entry point results in significant protection of the inner ear against labyrinthine spread of ototis media along the leadwire of the cochlear implant.
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ItemCochlear implantation in young children: studies on head growth, leadwire design and electrode fixation in the monkey model [Abstract]( 1992)For the safety of cochlear implantation in children under two, the implant assembly must not adversely effect the tissue of compromise head growth. Furthermore, growth changes and tissue responses should not impair functioning of the device. Dummy receiver-stimulators, interconnect plugs and leadwire-lengthening systems have been implanted for periods of 40 months in the young monkey to most effectively model the implantation of the young human child. The results show that implanting a receiver-stimulator package has no effect on skull growth or brain tissue under the package. The system for fixing the electrode at the fossa includes proved effective. There was marked osteoneogenesis in the mastoid cavity and this also resulted in fixation of the leadwire outside the cochlea. This study provides evidence for the safety of cochlear implantation in young children.