Graeme Clark Collection
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ItemA review of the biological, psychophysical, and speech processing principles used to design the tickle talker( 1992)The Tickle Talker is a wearable electrotactile speech processor, designed to be used by profoundly hearing-impaired children and adults in conjunction with lipreading and residual hearing. The effectiveness of such a device is affected by an interaction between biological, human engineering, psychophysical, and speech processing considerations. The requirements, the design principles, and the performance of the Tickle Talker in each of these areas will be discussed. Electrical stimulation of the nerve bundles lying along the sides of the fingers was chosen to provide safe, comfortable, energy-efficient stimulation of a well-organised and sensitive part of the tactile sensory system. This is achieved at a small cost to the appearance and mobility of one hand when using the Tickle Talker. The biphasic pulse waveform used to stimulate the nerve bundles has been chosen to ensure a biologically safe stimulus. The electrical parameters (pulse duration, pulse rate, and electrode position) that are used to encode speech information are varied within ranges that are matched to the characteristics of the tactile sense. The usable ranges and information-carrying potential of each of these parameters have been assessed in psychophysical experiments. A comparison of these results with similar experimental data for cochlear implant and hearing aid users is instructive in assessing the possible limitations of tactile and auditory speech processors. The results discussed will include the discrimination and identification of stimuli differing in intensity, duration and pulse rate; the identification of different spatial patterns of stimulation, and the detection of gaps in stimuli. In most respects, the tactile results are similar to the corresponding auditory measures. The resolution of temporal differences such as pulse rate discrimination or gap detection are generally not as good as in the auditory case, but may be as good or better than the corresponding results for some profoundly hearing-impaired individuals. The speech processor used in the Tickle Talker is a "feature extraction" device that explicitly estimates the second formant frequency, amplitude envelope, and fundamental frequency of the voice and encodes them in terms of electrode position, pulse width and pulse rate of the electrical stimulation pattern. Consideration of the psychophysical results and the speech information available from these parameters allows optimization of the Tickle Talker's operation and a broad estimation of its potential performance in speech discrimination. The perception of duration and place of articulation (front/back) of vowels, and the manner and voicing of consonants are expected to be improved by the Tickle Talker. Prosodic variations conveyed by pulse rate are expected to be perceived by some users, but not all. High frequency consonants such as: /s/,/z/./?/, and /t?/ are encoded in a particularly salient manner by the Tickle Talker.
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ItemCochlear pathology following chronic electrical stimulation of the auditory nerve. I: Normal hearing kittens( 1992)The present study examines the histopathological effects of long-term intracochlear electrical stimulation in young normal hearing animals. Eight-week old kittens were implanted with scala tympani electrode arrays and stimulated for periods of up to 1500 h using charge balanced biphasic current pulses at charge densities in the range 21-52 µC cm^-2 geom. per phase. Both click and electrically evoked auditory brainstem responses were periodically recorded to monitor the status of the hair cell and spiral ganglion cell populations. In addition, the impedance of the stimulating electrodes was measured daily to monitor their electrical characteristics during chronic implantation. Histopathological examination of the cochleas showed no evidence of stimulus induced damage to cochlear structures when compared with implanted, unstimulated control cochleas. Indeed, there was no statistically significant difference in the ganglion cell density adjacent to the stimulating electrodes when compared with a similar population in implanted control cochleas. In addition, hair cell loss, which was restricted to regions adjacent to the electrode array, was not influenced by the degree of electrical stimulation. These histopathological findings were consistent with the evoked potential recordings. Finally, electrode impedance data correlated well with the degree of tissue growth observed within the scala tympani. The present findings indicate that the young mammalian cochlea is no more susceptible to cochlear pathology following chronic implantation and electrical stimulation than is the adult.
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ItemA physiological investigation of chronic electrical stimulation with scala tympani electrodes in kittens( 1992)A physiological investigation of cochlear electrical stimulation was undertaken in six two-month-old kittens. The scala tympani electrodes were implanted and electrically stimulated using biphasic balanced electrical pulses' for periods of 1000-1500h in four ears. Four ears received implants for same period but without electrical stimulation. The other two ears served as normal control. The results indicated: 1) Chronic electrical stimulation of the cochlea within electrochemically safe limits did not influence the hearing of kittens and the normal delivery of impulses evoked by acoustic and electrical signals on the auditory brainstem pathway. 2) The wave shapes of EABRs were similar to those of ABRs. The aptitudes of EABRs showed a significant increase following chronic electrical stimulation, resulting in a leftward shift in the input/ output function. The absolute latencies and interwave latencies of waves II-III , III -IV and II -IV were significantly shorter than those of ABRs. These results imply that there was no adverse effect of chronic electrical stimulation on the maturing auditory systems of kittens using these electrical parameters and the mechanism of electrical hearing should be further studied.
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ItemExperimental study on extracochlear electric stimulation [Abstract]( 1992)The efficiency and feasibility of chronic extracochlear implantation and electric stimulation were studied in two adult cats and four 2-month kittens. The first electrode was placed on the round window by fixing the leadwire on the bridge of aditus between the middle ear and bulla cavity; the second electrode was placed on the surface of the tympanic promontory; the third was inserted into the temporal muscle out of the bulla and the forth fixed in transverse sinus with dental cement. ABRs and EABRs were recorded pre-and postoperatively and during electric stimulation.
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ItemA gated differential amplifier for recording physiological responses to electrical stimulation( 1992)Artifact from electrical stimulation imposes a problem for the recording of physiological responses to electrical stimulation. Here we describe a simple, low-cost, gated differential amplifier for the recording of physiological responses to electrical stimulation. The gain of the amplifier is set to 1 during electrical stimulation by setting the gate input to a high logic state to avoid overloading of the amplifier by the artifact. Following electrical stimulation, the gate input is set to a low logic state, resulting in again of 1000 for frequencies between 300 Hz and 25 kHz ( -3 dB points). The gain at low frequencies (0-0.2 Hz) is held constant at 1 to avoid transients in the output signal arising from changes in gain at these frequencies. The gain of the amplifier following stimulation (gate low) was independent of the magnitude of the artifact and was therefore suitable for the measurement of neural field potentials with low impedance electrodes.
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ItemA comparison of speech perception of cochlear implantees using the Spectral Maxima Sound Processor (SMSP) and the MSP (Multipeak) processor( 1992)The Spectral Maxima Sound Processor (SMSP) is a portable speech processor which has recently been developed at the University of Melbourne for use with multiple-electrode cochlear implants. In this processor, the six largest outputs (maxima) of 16 bandpass filters are used to stimulate the cochlea on a place basis at a constant rate. This speech processing strategy has been compared with the MSP(MULTIPEAK) strategy, in which four electrodes are selected for stimulation in every glottal pulse period. The study was undertaken on four postlinguistically deaf adults. The results show that, for this group of subjects, the performance of the SMSP processor was significantly better than that of the MSP(MUL TIPEAK) processor for the recognition of closed-set vowels and consonants, open-set monosyllabic words, and open-set sentences in noise, when using electrical stimulation alone. The SMSP mean scores were: vowels 91.3%, consonants 74.9%, words 57.4%, and sentences in noise 78.7%. The MSP(MULTIPEAK) mean scores were: vowels 76.3%, consonants 59.4%, words 39.9%, and sentences in noise 50.0%.
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ItemThe excitability of units in the central nucleus of the inferior colliculus to monaural electrical stimulation( 1992)Single unit responses to electric stimuli can be markedly different to those obtained with comparable acoustic stimuli. For the development of future cochlear implant coding strategies a detailed understanding of the effects of electrical stimulation is required. This study investigated the comparative number of single units exhibiting excitatory responses in the central nucleus of the inferior colliculus to monaural electric versus acoustic stimuli.
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ItemCochlear implants in children, adolescents, and prelinguistically deafened adults: speech perception( 1992)A group of 10 children, adolescents, and prelinguistically deafened adults were implanted with the 22-electrode cochlear implant (Cochlear Pty Ltd) at the University of Melbourne Cochlear Implant Clinic and have used the prosthesis for periods from 12 to 65 months. Postoperative performance on the majority of closed-set speech perception tests was significantly greater than chance, and significantly better than preoperative performance for all of the patients. Five of the children have achieved substantial scores on open-set speech tests using hearing without lipreading. Phoneme scores in monosyllabic words ranged from 30% to 72%; word scores in sentences ranged from 26% to 74%. Four of these 5 children were implanted during preadolescence (aged 5:5 to 10:2 years) and the fifth, who had a progressive loss, was implanted during adolescence (aged 14:8 years). The duration of profound deafness before implantation varied from 2 to 8 years. Improvements were also noted over postoperative data collection times for the younger children. The remaining 5 patients who did not demonstrate open-set recognition were implanted after a longer duration of profound deafness (aged 13:11 to 20:1 years). The results are discussed with reference to variables that may affect implant performance, such as age at onset of loss, duration of profound loss, age at implantation, and duration of implantation. They are compared with results for similar groups of children using hearing aids and cochlear implants.
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ItemClinical experience with the University of Melbourne multichannel electrotactile speech processor (Tickle Talker)( 1992)The Tickle Talker is a multiple channel electrotactile speech processor, developed for use by profoundly hearing-impaired adults and children. The device is intended to be used in combination with lipreading and aided residual hearing, to assist the greatest potential range of users. Sound detection and speech reception threshold levels for a group of 14 congenitally hearing-impaired children were shown to be lower when using the Tickle Talker than for hearing aids across the speech frequency range. Tactile-alone feature contrast testing with adults demonstrated that both segmental and suprasegmental speech feature information was available from the tactual display presented by the Tickle Talker. Clinical results from an ongoing program involving fourteen hearing-impaired children demonstrate benefits in speech perception achieved through use of the Tickle Talker. The children have a range of degree of hearing impairment and educational setting. Results show improvements in discrimination scores for vowel and consonant speech features, and increased scores for recognition of closed-set words and for open-set words and sentences. In addition, anecdotal evidence indicates changes in speech production which may be attributed to perceptual input from the device (both from perception of other speakers, and from voice self-monitoring). Results from a group of 4 adult patients show that tactile input may be effectively combined with either aided residual hearing, or aided residual hearing and lipreading to improve speech discrimination across a similar range of closed and open-set word and sentence tests and on speech tracking. The results indicate that some specific tailoring of the speech information provided through the device for the needs of users with differing degrees of hearing-impairment may be required to optimize potential benefits to speech discrimination.
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ItemSafety studies with the University of Melbourne multichannel electrotactile speech processor( 1992)Results of safety investigations conducted as an integral part of the development of a multichannel electrotactile speech processor (Tickle Talker™) are reported. Electrical parameters of the stimulus waveform, design of the electrode handset and cabling, and the electrical circuitry of the speech processor/stimulator and programming interface have been analysed for potential risks. Constant current biphasic square pulses delivered to electrodes positioned on the skin surface over the digital nerve bundles were chosen to optimize the safety, comfort, and function of the electrotactile stimulus. The device was battery-powered, and the user circuit was isolated from earth-referenced sources. Each electrode was isolated by capacitive coupling, preventing DC leakage of current to the user circuit. Studies of finger temperature showed slight cooling of the skin on the fingers of both stimulated and unstimulated hands for individual subjects following electrotactile stimulation through the Tickle Talker. Subsequent analysis of finger and hand vascular circulation in five subjects showed slight reductions in hand blood flow in some individuals. The results did not demonstrate a significant mean decrease in hand or finger blood flow following electrotactile stimulation. No evidence of sympathetic involvement was found, nor were any changes in vascular structure of the hand such as those associated with Raynaud's disease found. Evidence suggests that the decrease in temperature found in the initial study may be due to a change in the ratio of blood flow between arteriovenous anastomoses and nutritive capillary beds. Studies of: 1) changes in mean threshold and comfortable pulse widths over time; and, 2) changes in tactual sensitivity as measured by hot/cold, sharp/dull, and two-point difference limen discrimination, did not detect any systematic change in peripheral nervous system function following electrotactile stimulation. Analysis of electroencephalogram (EEG) recordings taken during electrotactile stimulation, and after relatively long periods of experience with the device did not show any pathological changes which might be associated with epileptic foci. In summary, no contraindications to long-term use of the Tickle Talker were detected in the studies performed.
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