Graeme Clark Collection
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ItemCochlear pathology following chronic electrical stimulation of the auditory nerve. I: Normal hearing kittens( 1992)The present study examines the histopathological effects of long-term intracochlear electrical stimulation in young normal hearing animals. Eight-week old kittens were implanted with scala tympani electrode arrays and stimulated for periods of up to 1500 h using charge balanced biphasic current pulses at charge densities in the range 21-52 µC cm^-2 geom. per phase. Both click and electrically evoked auditory brainstem responses were periodically recorded to monitor the status of the hair cell and spiral ganglion cell populations. In addition, the impedance of the stimulating electrodes was measured daily to monitor their electrical characteristics during chronic implantation. Histopathological examination of the cochleas showed no evidence of stimulus induced damage to cochlear structures when compared with implanted, unstimulated control cochleas. Indeed, there was no statistically significant difference in the ganglion cell density adjacent to the stimulating electrodes when compared with a similar population in implanted control cochleas. In addition, hair cell loss, which was restricted to regions adjacent to the electrode array, was not influenced by the degree of electrical stimulation. These histopathological findings were consistent with the evoked potential recordings. Finally, electrode impedance data correlated well with the degree of tissue growth observed within the scala tympani. The present findings indicate that the young mammalian cochlea is no more susceptible to cochlear pathology following chronic implantation and electrical stimulation than is the adult.
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ItemA physiological investigation of chronic electrical stimulation with scala tympani electrodes in kittens( 1992)A physiological investigation of cochlear electrical stimulation was undertaken in six two-month-old kittens. The scala tympani electrodes were implanted and electrically stimulated using biphasic balanced electrical pulses' for periods of 1000-1500h in four ears. Four ears received implants for same period but without electrical stimulation. The other two ears served as normal control. The results indicated: 1) Chronic electrical stimulation of the cochlea within electrochemically safe limits did not influence the hearing of kittens and the normal delivery of impulses evoked by acoustic and electrical signals on the auditory brainstem pathway. 2) The wave shapes of EABRs were similar to those of ABRs. The aptitudes of EABRs showed a significant increase following chronic electrical stimulation, resulting in a leftward shift in the input/ output function. The absolute latencies and interwave latencies of waves II-III , III -IV and II -IV were significantly shorter than those of ABRs. These results imply that there was no adverse effect of chronic electrical stimulation on the maturing auditory systems of kittens using these electrical parameters and the mechanism of electrical hearing should be further studied.
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ItemA gated differential amplifier for recording physiological responses to electrical stimulation( 1992)Artifact from electrical stimulation imposes a problem for the recording of physiological responses to electrical stimulation. Here we describe a simple, low-cost, gated differential amplifier for the recording of physiological responses to electrical stimulation. The gain of the amplifier is set to 1 during electrical stimulation by setting the gate input to a high logic state to avoid overloading of the amplifier by the artifact. Following electrical stimulation, the gate input is set to a low logic state, resulting in again of 1000 for frequencies between 300 Hz and 25 kHz ( -3 dB points). The gain at low frequencies (0-0.2 Hz) is held constant at 1 to avoid transients in the output signal arising from changes in gain at these frequencies. The gain of the amplifier following stimulation (gate low) was independent of the magnitude of the artifact and was therefore suitable for the measurement of neural field potentials with low impedance electrodes.
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ItemSpeech processing for cochlear implants(JAI Press Ltd, 1992)The cochlear implant is a hearing prosthesis designed to replace the function of the ear. The operation of the prosthesis can be described as a sequence of four functions: the processing of the acoustic signal received by a microphone; the transfer of the processed signal through the skin; the creation of neural activity in the auditory nerve; and the integration of the experience of this neural activity into the perceptual and cognitive processing of the implantee.
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ItemA comparison of speech perception of cochlear implantees using the Spectral Maxima Sound Processor (SMSP) and the MSP (Multipeak) processor( 1992)The Spectral Maxima Sound Processor (SMSP) is a portable speech processor which has recently been developed at the University of Melbourne for use with multiple-electrode cochlear implants. In this processor, the six largest outputs (maxima) of 16 bandpass filters are used to stimulate the cochlea on a place basis at a constant rate. This speech processing strategy has been compared with the MSP(MULTIPEAK) strategy, in which four electrodes are selected for stimulation in every glottal pulse period. The study was undertaken on four postlinguistically deaf adults. The results show that, for this group of subjects, the performance of the SMSP processor was significantly better than that of the MSP(MUL TIPEAK) processor for the recognition of closed-set vowels and consonants, open-set monosyllabic words, and open-set sentences in noise, when using electrical stimulation alone. The SMSP mean scores were: vowels 91.3%, consonants 74.9%, words 57.4%, and sentences in noise 78.7%. The MSP(MULTIPEAK) mean scores were: vowels 76.3%, consonants 59.4%, words 39.9%, and sentences in noise 50.0%.
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ItemThe development of speech processing strategies for the University of Melbourne/cochlear multiple channel implantable hearing prosthesis.( 1992)The speech processing strategies that have been used with the University of Melbourne/Cochlear multiple channel implantable hearing prosthesis have been developed systematically from the inaugural one that extracted the second formant and presented this on a place coding basis and the voicing frequency which determined the rate of stimulation. Speech processing has also depended heavily on biological research to ensure that the stimulus parameters used or the operative approach did not damage the spiral ganglion cells it was hoped to stimulate. The advances in speech processing from Melbourne primarily have been to extract more features and spectral information and present this on a place coding basis. This has led to a progressive improvement in speech perception, and a small number of patients can achieve nearly 100% correct scores for open sets of phonetically-balanced words using electrical stimulation alone.
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ItemCochleotopic selectivity of a multichannel scala tympani electrode array using the 2-deoxyglucose technique( 1992)The 2-deoxyglucose (2-DG) technique was used to study the cochleotopic selectivity of a multichannel scala tympani electrode array in four cats with another acting as an unstimulated control. Each animal was unilaterally deafened and a multichannel electrode array inserted 6 mm into the scala tympani. Thresholds to electrical stimulation were determined by recording electrically evoked auditory brainstem responses (EABRs). Each animal was injected with 2-DG, and electrically stimulated using bipolar electrodes located either distal or proximal to the round window. The contralateral- ear was stimulated with acoustic tone pips at frequencies that matched the electrode place. Stimulation of both distal and proximal bipolar electrodes at 3X EABR threshold, evoked localized 2-DG labelling in both ipsilateral cochlear nucleus (CN) and the contralateral inferior colliculus (IC), which was very similar in orientation and breadth to labelling evoked by the contralateral tone pips. The cochleotopic position of labelling to proximal stimulation was located in the 24-26 kHz region of each structure, whereas the distal labelling was located around 12 kHz. Distal stimulation at 10 X EABR threshold produced very broad 2-DG labelling in IC centered around the 12 kHz place. The present 2-DG results clearly illustrate cochleotopic selectivity using multichannel bipolar scala tympani electrodes. The extent of this selectivity is dependent on electrical stimulus levels. The 2-DG technique has great potential in evaluating the efficacy of new electrode array designs.
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ItemInvestigation of curved intracochlear electrode arrays [Abstract]( 1992)It has been demonstrated that the Melbourne/Cochlear multi-channel cochlear implant is safe and effective for use in profoundly-totally deaf patients. Recent studies have highlighted the importance of deaf insertion and placing the electrodes closer to the spiral ganglion neurons. In order to improve the electrode insertion depth and proximity to the modiolus, we have investigated curved electrode arrays. Prototypes of such arrays and their accessory inserter have been made. Trial insertions were performed on skeletonized cochleae of human temporal bones. The preliminary results showed that, when compared with conventional straight electrode arrays, the curved arrays could be inserted deeper and located closer to the modiolus. These findings indicate that the curved --.~ electrodes currently under investigation should result in a reduction in stimulus threshold and improve pitch perception and may also result in the use of more channels of stimulation.
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ItemThe origin of electrophonic activity evoked by electrical stimulation of the cochlea( 1992)Electrophonic activation of auditory nerve fibres via electrical stimulation is only observed in cochleas with residual hair cells. While the generation of neural activity associated with this phenomenon is thought to ultimately occur at the inner hair cell synapse (1) it is unclear whether hair cells are activated directly by the electrical stimulus or mechanically via a travelling wave propagating along the basilar membrane. Support for the travelling wave hypothesis has recently come from a masking study using evoked potentials (2). To provide verification of these results, we measured the latency of the electrophonic activity recorded in single ventral cochlear nucleus (VCN) units of known characteristic frequency (CF). Stimulating electrodes were placed on, or just inside the round window of normal hearing anaesthetized cats (n=6). The response of single VCN units were recorded extracellularly and units exhibiting "primary like" activity (3) were analysed. Each unit's CF to acoustic stimulation and response properties to biphasic electric pulses were determined. Electrophonic activity was identified by its long latency (> 2.5 ms) and poor synchronization compared with the response evoked by direct electrical stimulation. Electrophonic activity was observed in 20 units -approximately 25% of the units isolated. These responses were more commonly recorded from cochleas in which the round window had not been opened. The latency of the electrophonic response varied inversely with CF, implying that the response is generated at the basilar membrane and results in a mechanical travelling wave. Finally, no electrophonic activity was observed in units with CFs greater than 10 kHz. Our data would predict that the latency of electrophonic activity in these units -if present -would be very short. Presumably its absence is a result of refractoriness within auditory nerve fibres following activity evoked by direct electrical stimulation.
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ItemResponses from single units in the dorsal cochlear nucleus to electrical stimulation of the cochlea( 1992)To help improve our understanding of how the brain responds to electrical stimulation of the auditory nerve we have examined the responses of dorsal cochlear nucleus (DCN) units to both acoustic stimulation and electrical stimulation of the cochlea. This work extended our previous studies which have compared the responses to electrical and acoustic stimulation In the auditory nerve (Javel et al 1987, Ann. Otol. Rhinol. laryngeal. Suppl. 128, 96:2630) and the ventral cochlear nucleus (Shepherd et al 1988, NIH Contract NO1-NS-72342, 5th Quarterly Progress Report).