Graeme Clark Collection
Permanent URI for this collection
Search Results
1 - 9 of 9
-
ItemSpatial representation of the cochlea within the inferior colliculus of neonatally deafened kittens following chronic electrical stimulation of the auditory nerve [Abstract]( 1995)The orderly tonotopic representation of the cochlea is accurately reproduced within the central auditory system of normal hearing animals. Any degradation of this representation as a result of a neonatal hearing loss or chronic electrical stimulation during development could have important implications for the use of multichannel cochlear implants in young children. In the present study we have used 2-deoxyglucose autoradiography (2-00) to examine the topographic representation of the cochlea within the inferior colliculus (IC) of neonatally deafened kittens following periods of chronic intracochlear electrical stimulation.
-
ItemThe pitch of amplitude-modulated electrical stimuli in cochlear implantees [Abstract]( 1993)The ability of cochlear implantees to detect amplitude modulation of pulsatile electrical stimulation, suggests that some speech feature information may be conveyed effectively by this means. For example, modulations at the fundamental frequency of speech may provide a voice pitch percept to implantees, particularly in speech processing strategies which generate constant-rate stimulation. The pitch evoked by sinusoidally modulated current pulse trains on a single electrodes has been studied. Modulation frequencies of 100, 150 and 200Hz, and carrier pulse rates varying from 200 to 1200Hz, were used. The results showed that the pitch of the stimulation was related to the modulation frequency, provided that either the carrier rate was a multiple of the modulation frequency, or the carrier rate was sufficiently high (at least four times the modulation frequency for the stimuli studied here). Furthermore, when the modulated stimuli were matched in pitch to non-modulated pulse trains, it was. found that the rate of the matched non-modulated stimuli was close to but somewhat higher than the modulation frequency. This difference depended on the carrier rate and varied among subjects.
-
ItemDecrement in auditory nerve function following acute high rate stimulation in guinea pigs [Abstract]( 1995)Cochlear implants have been shown to successfully provide profoundly deaf patients with auditory cues for speech discrimination. Psychophysical studies suggested that speech processing strategies based on stimulus rates of up to 1000 pulses per second (pps) may lead to an improvement in speech perception, due to a better representation of the rapid variations in the amplitude of speech. However, "neural fatigue" has been known to occur following brief periods of electrical stimulation at rates high enough to ensure that stimuli occur within the neurons relative refractory period, and has been shown to depend on stimulus duration and rate of the evoked neural activity. Prolonged electrical stimulation at these high stimulus rates could, therefore, have an adverse effect on the neurons metabolism and result in cellular energy depletion.
-
ItemThe auditory cortex and auditory deprivation: experience with cochlear implants in the congenitally deaf [Abstract]( 1995)The primary auditory cortex (AI) exhibits a topographic representation of the organ of Corti in normal hearing animals. Plasticity studies have shown that this orderly representation of frequency can be modified following a restricted hearing loss or by behavioural trainingl,2. Little is known, however, of the effects of a profound hearing loss on AI, although a number of early studies have suggested an enhancement of activity from other modalities3. Knowledge of the functional status of the central auditory pathway in the profoundly deaf, and the ability of these structures to undergo reorganization particularly following long periods of auditory deprivation - are important issues for the clinical management of cochlear implant patients. In this paper we review our recent clinical and experimental experience with cochlear implants in the congenitally deaf.
-
ItemResults of multichannel cochlear implantation in very young children [Abstract]( 1995)Most researchers and clinicians working in the cochlear implant field have assumed that profoundly deaf children will have a better prognosis in terms of speech perception, speech production and language development, implanted at as young an age as possible. However, it has been difficult to gather direct evidence for this hypothesis due to the problems in assessing children under the age of five years with formal tests.
-
ItemSpeech perception benefits for implanted children with preoperative residual hearing [Abstract]( 1995)Since the implantation of the first children with the Nucleus 22-channel cochlear prosthesis in Melbourne in 1985, there has been rapid expansion in the number of implanted children world-wide. Improved surgical technique and experience in paediatric assessment and management have contributed to a trend to implant very young children. At the same time there has also been continuing development of improved speech processing strategies resulting in greater speech perception benefits.
-
ItemEvaluation of leadwire fixation for paediatric cochlear implants [Abstract]( 1994)A paediatric cochlear implant should include a leadwire system that can readily expand in the presence of tissue adhesions and can be effectively fixed at a site close to the cochlea to ensure that the electrode array is not displaced during skull growth. In this study, leadwires were implanted in six young animals for a period of five months. During explantation, the mean force � standard deviation required to expand individual leadwire was found to be 12.5 � 5.0g. In order to evaluate the efficacy of leadwire fixation techniques, four fixation procedures were initially developed in human temporal bones and subsequently used to fix leadwires implanted in the temporal bones of eight animals for a period of four months. Leadwires were fixed by platinum wires at the fossa incudis or by platinum wires with a titanium barbed nail at the mastoid. The biomechanical evaluation revealed that the forces required to displace the leadwire from fixation points were 70.6 � 33.5g. Significantly, the forces required to withdraw a chronically implanted electrode array from an animal cochlea were 1.5 � 0.4g. The present results highlight the importance of an effective leadwire fixation technique for paediatric cochlear implants, particularly in preventing the displacement of an electrode array from the cochlea during skull growth.
-
ItemLatest results and future directions in speech processing for the Nucleus multichannel cochlear prosthesis [Abstract]( 1995)The past two years has seen the introduction of the Speak speech encoding scheme for most patients using the Nucleus 22-channel cochlear prosthesis. This scheme, based on the Spectral Maxima Speech Processor (SMSP) developed at the University of Melbourne, uses a bank of 20 band-pass filters to present detailed spectral information to the intracochlear electrode array. Clinical trials of this speech processor have shown highly significant improvements over the previous Multipeak scheme in English, German, French and Japanese speaking patients. The largest improvements were evident for open-set testing in background noise, which represents a more realistic measure of everyday benefit than testing in quiet. The latest results for adults who have changed from Multipeak to Speak will be presented, along with results over time for newly-implanted patients using the Speak scheme. New research aimed at improving the speech processing in both the spectral and temporal domains will also be discussed.
-
ItemElectrical stimulation of the auditory nerve: comparison of half-band with full-band scala tympani bipolar electrodes( 1993)The Melbourne/Cochlear auditory prosthesis uses an intracochlear electrode array containing 22 circumferential full-band electrodes mounted on a Silastic carrier. It could be hypothesized that half-band electrodes, oriented towards the modiolus, would produce lower stimulus thresholds than conventional full-band electrodes. This hypothesis is based on the assumption that, compared with full-band electrodes, half-band electrodes would produce an electrical field in which a greater proportion of the current would excite a defined group of neurons. In order to verify this hypothesis we recorded electrically evoked auditory brainstem responses (EABRs) for both full- and half-band electrodes inserted in the scala tympani of deafened cats. EABR thresholds for half-band electrodes oriented towards the modiolus were not significantly different from thresholds evoked using full-band electrodes (p>0.05, paired t-test), whereas thresholds evoked using half-band electrodes oriented towards the outer scala wall were significantly higher (p<0.01) than either the modiolar half-band or the full-band electrodes. These physiological results suggest that the electrical field generated within the auditory nerve by modiolar oriented half-band electrodes does not differ significantly from that produced by full-band electrodes. On the basis of these results, together with the fact that half-band electrodes would have higher current densities and electrode impedances, and would require careful orientation during implantation, we consider that there is no benefit in incorporating half-band electrodes in the design of scala tympani electrode arrays.