Graeme Clark Collection
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ItemThe histopathology of the human temporal bone and auditory central nervous system following cochlear implantation in a patient: correlation with psychophysics and speech perception results( 1988)Cochlear implantation has become a recognised surgical procedure for the management of a profound-total hearing loss, especially in patients who have previously had hearing before going deaf (postlingual deafness). Nevertheless, it is important for progress in the field that patients who have had a cochlear implant, bequeath their temporal bones for research. This will then make it possible to further assess the safety of the procedure, and the factors that are important for its effectiveness. Biological safety has been assessed in a number of studies on animals, in particular, the biocompatibility of the materials used (1,2), the histopathological effects of long-term implantation on the cochlea (3, 4, 5, 6, 7, 8), and the effects of chronic electrical stimulation on the viability of spiral ganglion cells (9, 10, 11, 12). In studying the temporal bones of deceased cochlear implant patients it is possible to help establish that the animal experimental results are applicable to Man. Surgical trauma has been most frequently evaluated by inserting electrodes into cadaver temporal bones. It is important, however, to examine bones that have been previously implanted surgically to ensure that the cadaver findings are applicable to operations on patients. The effectiveness of cochlear implantation can be studied by correlating the histopathological findings, the dendrite and spiral ganglion cell densities, in particular, with the psychophysical and speech perception results. Other benefits also accrue, for example, establishing the accuracy of preoperative X-rays and electrical stimulation of the promontory in predicting cochlear pathology and spiral ganglion cell numbers. For the above reasons it has been especially interesting to examine both the temporal bones and central nervous system from one of our patients (patient 13) who participated in the initial clinical trial of the Cochlear Proprietary Limited (a member of the Nucleus group) multiple-electrode cochlear prosthesis, and who died due to a myocardial infarction following coronary bypass surgery.
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ItemThe clinical trial of a multi-channel cochlear prosthesis( 1983)The results of a multiple-electrode cochlear implant carried out on 1st August, 1978 on a totally deaf patient (post-lingual hearing loss) showed that he could perceive sounds of different pitches depending on the electrode stimulated, and this finding was consistent with the place theory of frequency coding. Furthermore, stimulating individual electrodes produced percepts which the patient described as vowel-like in quality. The patient could also perceive different pitches which varied with the rate of stimulation up to 200 pulses/second, but at higher rates he had difficulties perceiving pitch changes (Clark et al. 1978; Tong et al, 1979). As a result of the psychophysical studies a speech processor was developed. The speech processor extracted: firstly, the voicing frequency to help the patient hear the rhythm of speech and know whether a speech sound was voiced or unvoiced (e.g., /b/ versus /p/); and, secondly, the second formant to enable the patient to recognize vowels and consonants and so hear words. In order to maximize speech intelligibility, the second formant stimulated an appropriate electrode, and the rate of stimulation on that electrode was related to the voicing frequency.