Graeme Clark Collection

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http://hdl.handle.net/11343/375

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Author: Seligman, Peter × Author: Shepherd, Robert × Type: Conference Item × Subject: electrical stimulation ×

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    Reduction in excitability of the auditory nerve in guinea pigs following acute high rate electrical stimulation [Abstract]
    Huang, C. Q. ; Shepherd, R. K. ; Seligman, P. M. ; Clark, Graeme M. ( 1996)
    Electrical stimulation of neural tissue involves the transfer of charge to tissue via electrodes. Safe charge transfer can be achieved using biphasic current pulses designed to reduce the generation of direct current (DC) or the production of electrochemical products. However, neural stimulators must also use capacitors in series with electrodes, or electrode shorting between current pulses, to further minimize DC due to electrode polarization.
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    Electrical stimulus induced changes in excitability of the auditory nerve
    Huang, C. O. ; Shepherd, Robert K. ; Seligman, P. M. ; Clark, Graeme M. ( 1997)
    High rate electrical stimulation of the auditory nerve using stimulus intensities well above the clinical limits can induce a significant reduction in the excitability of the auditory nerve as measured by a decrement in the amplitude of the electrically evoked auditory brainstem response (EABR). Two potential mechanisms may be associated with this stimulus induced reduction in activity: 1) stimulus induced prolonged neuronal hyperactivity; and 2) the generation of adverse electrochemical productions from the electrode surface. The purpose of the present study was to assess the extent to which adverse electrochemical damage contributes to the stimulus induced reduction in auditory nerve excitability. Twenty-six adult guinea pigs anaesthetized with ketamine (40 mg/kg i.p.) and xylazine (4 mglkg i.p.), were bilaterally implanted and unilaterally stimulated for two hours using a stimulus intensity of two or four times EABR threshold. Stimulus rates of 200, 400, or 1000 pulses/s (pps) were delivered via a standard platinum scala tympani electrode or large surface area ("high Q") platinum electrode.