Graeme Clark Collection

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Author: Shepherd, Robert × End date: 1997 × Start date: 1992 × Subject: cochlear implant × Subject: cochlear pathology × Subject: otolaryngology × Subject: safety studies ×

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    Electrical stimulation of the auditory nerve in deaf kittens: effects on the spiral ganglion [Abstract]
    Shepherd, R. K. ; Matsushima, J ; Clark, Graeme M. ( 1992)
    Cochlear pathology following the administration of ototoxic drugs results in a widespread and rapid loss of sensory hair cells followed by a gradual degeneration of auditory nerve fibres and their cell bodies, the spiral ganglion. Recently, two studies have described increased spiral ganglion cell survival in the cochleas of deafened animals following chronic electrical stimulation of the auditory nerve (Hartshorn et al., 1991; Leake et al., ]991). If electrical stimulation is shown to have a trophic effect on degenerating auditory nerve fibres, these findings will significantly influence the preoperative management of cochlear implant patients. The aim of the present study was to corroborate these earlier reports and to evaluate the general tissue response of deafened cochleae in young animals following chronic electrical stimulation.