Graeme Clark Collection

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    Acute effects of high-rate stimulation on auditory nerve function in guinea pigs
    Tykocinski, M. ; Shepherd, R. K. ; Clark, Graeme M. ( 1995)
    Cochlear implants have been shown to successfully provide profoundly deaf patients with auditory cues for speech discrimination. Furthermore, a number of safety studies using the Melbourne/Cochlear electrode array indicated that chronic electrical stimulation using charge-balanced biphasic current pulses and stimulus rates between 100 and 500 pulses per second (pps) do not result in additional spiral ganglion loss or general cochlear pathology.1-3 However, safe maximum levels for stimulus parameters (stimulus rate, charge per phase, charge density) have not yet been adequately defined.
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    Physiological and histopathological effects of chronic monopolar high rate stimulation on the auditory nerve
    TYKOCINSKI, MICHAEL ; Linahan, N. ; Shepherd, R. K. ; Clark, Graeme M. ( 2000)
    Speech processing strategies based on high rate electrical stimulation have been associated with improvements in speech perception among cochlear implant users. The present study was designed to evaluate the electrophysiological and histopathological effects of long-term intracochlear monopolar stimulation at the maximum stimulus rate of the current Nucleus Cochlear implant system (14493 pulses/s) as part of our ongoing investigations of safety issues associated with cochlear implants
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    Insertion study using new peri-modiolar electrode array designs [Abstract]
    Treaba, Claudiu ; Clark, Graeme M. ; Cowan, Robert S. ; Tykocinski, Michael J. ; Cohen, Lawrence T. ; Saunders, Elaine ; Pyman, Brian C. ; Briggs, Robert S. ; Dahm, Markus C. ( 1999)
    Intracochlear multi-channel cochlear implants have been shown to successfully provide auditory information for profoundly deaf patients by electrically stimulating discrete populations of auditory nerve fibers via a scala tympani (ST) electrode array. Histological and radiological examination of implanted human temporal bones showed that the current straight Nucleus® array is usually positioned against the outer wall of the ST. An electrode array close to the modiolus could be expected to reduce stimulation thresholds and result in a more localized neural excitation pattern.