Graeme Clark Collection

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End date: 1989 × Start date: 1987 × Subject: cochlear implant × Subject: ear infection × Subject: otology ×

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    Middle ear infection postimplantation: response of the round window membrane to Streptococcus pyogenes
    Cranswick, N. E. ; Franz, B. K-H. ; Clark, Graeme M. ; Shepherd, R. K. ; Bloom, D. M. ( 1987)
    The seal of the implanted round window membrane to resist Streptococcus pyogenes invasion from the middle ear was investigated in 12 cats. Results showed that the implanted round window membrane is able to form a barrier for S pyogenes starting 1 week postimplantation. Under normal conditions S pyogenes did not pass through the round window membrane, nor through the gap that existed between the membrane and the prosthesis. Mechanical disruption of the round window seal, however, and severe inflammatory response to S pyogenes caused the infection to extend into the inner ear.
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    Pneumococcal middle ear infection and cochlear implantation
    Berkowitz, R. G. ; Franz, B. K-H. ; Shepherd, R. K. ; Clark, Graeme M. ; Bloom, D. M. ( 1987)
    A limited study for the experimental induction of pneumococcal otitis media is presented. It is a useful model to study the effects of otitis media in the implanted and nonimplanted cochlea of the cat. Pneumococcal otitis media caused minor pathological changes in two nonimplanted cochleas and more widespread changes together with significant loss of neural elements in two implanted cochleas. However, the small number of animals used in this study did not allow us to distinguish between the effects of electrode insertion trauma, infection, or the combination of both.