Graeme Clark Collection
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ItemPaediatric cochlear implant surgery [Abstract]( 1992)The operation in children is similar to that in adults, but special care needs to be taken with the skin flap, the anchoring of the electrode array and the sealing of .the cochleostomy. Research into the effects of head growth and otitis media in an implanted ear indicates that these should not be a problem. Surgical complications are also similar to those in adults, with the most common being related to the skin flap. The major complication rate at 4 % is slightly less than that in adults and most of these get effective implant function.
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ItemThe development of auditory comprehension in children after receiving a cochlear multiple-channel implant( 1992)Since late 1989, half the cochlear implant patients at the Royal Victorian Eye and Ear Hospital have been young children. There is a gradual improvement of auditory comprehension in most cases using the criteria of environmental sound detection, as well as, prosody, high frequency phoneme and word discrimination. The rate of improvement and final result depend on the duration of deafness, presence of residual hearing, and quality of auditory-oral habilitation. Younger children usually progress more quickly than older children. Some adolescents who use Total Communication and who have no residual hearing, achieve assistance with lipreading. Children with Usher's Syndrome should be actively encouraged to participate in auditory-oral habilitation should they become totally deaf or blind.
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ItemThe effect of inflammation on blood vessel area as a cause of variation in ganglion cell density measurements in the cat cochlea [Abstract]( 1992)The success of a cochlear implant depends on an adequate number of surviving spiral ganglion cells. Further loss of ganglion cells may arise from the biology of cochlear implantation itself. The quantitative analysis of ganglion cells is, therefore, an important consideration when assessing the biological safety of a cochlear implant.
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ItemFuture directions in the clinical application of multichannel cochlear prostheses [Abstract]( 1992)Three main areas of work at the University of Melbourne relating to the clinical application of multichannel cochlear prostheses will be discussed. Speech perception results for 40 children and adolescents implanted with the Nucleus multichannel device will be presented with an analysis of potentially predictive clinical factors. Overall results have shown that 60% of the children have developed useful open-set speech recognition ability without visual cues. Due to the improved speech perception for postlinguistically deafened adult cochlear implant patients, the multichannel implant has become a viable alternative for patients with some useful residual hearing. A "bimodal" speech processor which provides acoustic output for the residual hearing ear and electrical output for the cochlear implant will also be discussed. This device provides a flexible, programmable acoustic processor which can make use of feature coding aspects of the implant processing. The "bimodal" device has also addressed problems of incompatibility of the implant signal with the acoustic signal from conventional hearing aids. Results for the new "Spectral Maxima Speech Processor" (SMSP) will also be presented. The SMSP has shown improved speech perception performance in quiet and in noise when compared with the MSP (MULTIPEAK) system, currently in use with the Nucleus device. Results for four subjects with the SMSP showed mean scores of 57.4% for open-set monosyllabic words in quiet, and 78.7% for open-set sentences in a 10 dB signal-to-noise ratio
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ItemAn improved speech processor for a 22-electrode cochelar implant [Abstract]( 1992)A spectral maxima speech processing strategy ( SMSP) has been developed as a result of research to improve the speech perception performance of a multiple-channel cochlear implant. With this speech processing strategy. the six spectral maxima from the outputs of 16 band pass filters are used to stimulate the cochlea on a place basis at a constant rate. This SMSP strategy has been compared with the MSP-MULTIPEAK strategy, the present speech processor provided by Cochlear Pty. Limited, on four postlinguistically deaf adults. The study showed that the SMSP strategy was significantly better than the MSP-MULTJPEAK for the recognition of closed-set vowels and consonants, and open-set monosyllable words and sentences in background noise.
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ItemInvestigation of curved intracochlear electrode arrays [Abstract]( 1992)It has been demonstrated that the Melbourne/Cochlear multi-channel cochlear implant is safe and effective for use in profoundly-totally deaf patients. Recent studies have highlighted the importance of deaf insertion and placing the electrodes closer to the spiral ganglion neurons. In order to improve the electrode insertion depth and proximity to the modiolus, we have investigated curved electrode arrays. Prototypes of such arrays and their accessory inserter have been made. Trial insertions were performed on skeletonized cochleae of human temporal bones. The preliminary results showed that, when compared with conventional straight electrode arrays, the curved arrays could be inserted deeper and located closer to the modiolus. These findings indicate that the curved --.~ electrodes currently under investigation should result in a reduction in stimulus threshold and improve pitch perception and may also result in the use of more channels of stimulation.
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ItemElectrical stimulation of the auditory nerve in deaf kittens: effects on the spiral ganglion [Abstract]( 1992)Cochlear pathology following the administration of ototoxic drugs results in a widespread and rapid loss of sensory hair cells followed by a gradual degeneration of auditory nerve fibres and their cell bodies, the spiral ganglion. Recently, two studies have described increased spiral ganglion cell survival in the cochleas of deafened animals following chronic electrical stimulation of the auditory nerve (Hartshorn et al., 1991; Leake et al., ]991). If electrical stimulation is shown to have a trophic effect on degenerating auditory nerve fibres, these findings will significantly influence the preoperative management of cochlear implant patients. The aim of the present study was to corroborate these earlier reports and to evaluate the general tissue response of deafened cochleae in young animals following chronic electrical stimulation.
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ItemThe origin of electrophonic activity evoked by electrical stimulation of the cochlea( 1992)Electrophonic activation of auditory nerve fibres via electrical stimulation is only observed in cochleas with residual hair cells. While the generation of neural activity associated with this phenomenon is thought to ultimately occur at the inner hair cell synapse (1) it is unclear whether hair cells are activated directly by the electrical stimulus or mechanically via a travelling wave propagating along the basilar membrane. Support for the travelling wave hypothesis has recently come from a masking study using evoked potentials (2). To provide verification of these results, we measured the latency of the electrophonic activity recorded in single ventral cochlear nucleus (VCN) units of known characteristic frequency (CF). Stimulating electrodes were placed on, or just inside the round window of normal hearing anaesthetized cats (n=6). The response of single VCN units were recorded extracellularly and units exhibiting "primary like" activity (3) were analysed. Each unit's CF to acoustic stimulation and response properties to biphasic electric pulses were determined. Electrophonic activity was identified by its long latency (> 2.5 ms) and poor synchronization compared with the response evoked by direct electrical stimulation. Electrophonic activity was observed in 20 units -approximately 25% of the units isolated. These responses were more commonly recorded from cochleas in which the round window had not been opened. The latency of the electrophonic response varied inversely with CF, implying that the response is generated at the basilar membrane and results in a mechanical travelling wave. Finally, no electrophonic activity was observed in units with CFs greater than 10 kHz. Our data would predict that the latency of electrophonic activity in these units -if present -would be very short. Presumably its absence is a result of refractoriness within auditory nerve fibres following activity evoked by direct electrical stimulation.
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ItemMultichannel cochlear implants in children: an overview of experimental and clinical results at the University of Melbourne [Opening Lecture]( 1992)During the last decade there has been great progress in the clinical management of profound, postlinguistically deafened adults through the use of multichannel cochlear implants. The device developed by The University of Melbourne in association with Cochlear Pty Ltd, electrically stimulates selective regions of the auditory nerve using an array of 22 platinum (Pt) electrodes located in the scala tympani. Its development followed basic experimental studies and the development and evaluation of a prototype device in the 1970's. Following safety studies and a successful clinical trial, the Melbourne/Cochlear multichannel implant was approved for use in adults by the United States Food and Drug Administration (FDA) in 1985. More than 3000 patients throughout the world have since been implanted with this device, many being able to understand a significant amount of unfamiliar, connected speech without lipreading Following miniaturization of the implant, it became suitable for use with children. In 1990, after additional biological safety and clinical investigations, the FDA approved the use of the Melbourne/Cochlear multichannel implant for profoundly deaf children above the age of two years. And in 1991, the device received the medical device implantation approval certificate from the Japanese Government. The present paper presents an overview of our recent biological safety studies and clinical experience in children, and discusses the likely future development of these devices.
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ItemResponses from single units in the dorsal cochlear nucleus to electrical stimulation of the cochlea( 1992)To help improve our understanding of how the brain responds to electrical stimulation of the auditory nerve we have examined the responses of dorsal cochlear nucleus (DCN) units to both acoustic stimulation and electrical stimulation of the cochlea. This work extended our previous studies which have compared the responses to electrical and acoustic stimulation In the auditory nerve (Javel et al 1987, Ann. Otol. Rhinol. laryngeal. Suppl. 128, 96:2630) and the ventral cochlear nucleus (Shepherd et al 1988, NIH Contract NO1-NS-72342, 5th Quarterly Progress Report).